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Systematic Review ARTICLE Provisionally accepted The full-text will be published soon. Notify me

Front. Pharmacol. | doi: 10.3389/fphar.2019.01075

Kawasaki disease and the use of the rotavirus vaccine in children: a systematic review and meta-analysis

  • 1Universidade de Sorocaba, Brazil
  • 2Federal University of Amazonas, Brazil

Background: The vaccine against the rotavirus is an effective measure in reducing hospitalizations and mortality caused by the virus. However, its use can result in serious adverse effects. The available evidence on Kawasaki disease has not yet been reported in the literature. This study investigated the risk of developing Kawasaki disease with the use of rotavirus vaccines in children. Methods: This is a systematic review of data collected from studies retrieved on the following databases: COCHRANE, MEDLINE, EMBASE, CINAHL, SCOPUS, Web of Science, Health Star, LILACS, Clinical trial.gov and International Clinical Trials Registry Platform, up to the 15th of August 2018, with no restrictions on language or date of publication. The outcomes measured were incidence of Kawasaki disease, risk of developing the disease and rate of discontinuation of the vaccination schedule. Four reviewers independently selected the studies, performed data extraction and assessed the quality of evidence. A meta-analysis of random effects was performed. Results: A total of 13 publications were included, with a population of 164,434 children included in the meta-analysis. The incidence of Kawasaki disease (24 cases per 100,000, 95%CI=11.98-48.26) in the vaccinated children was low. No difference between the vaccines was found in the prevalence rate of adverse effects (RR=1.55, 95%CI=0.41-5.93). Use of the vaccines were not associated with risk of developing Kawasaki disease (low quality evidence). None of the studies reported the rate of discontinuation of the vaccination schedule. Conclusions: The vaccines were associated with a low incidence of developing Kawasaki disease, showing no association with this serious adverse effect.

Keywords: kawasaki disease, rotavirus vaccine., Systematic review, adverse effect, Safety

Received: 11 Jan 2019; Accepted: 23 Aug 2019.

Copyright: © 2019 Mellone, Silva, Moura, Lopes, Barberato-Filho, DEL FIOL and Bergamaschi. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence: Dr. Cristiane D. Bergamaschi, Universidade de Sorocaba, Sorocaba, 18023-000, Sao Paulo, Brazil, cristiane.motta@prof.uniso.br