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Systematic Review ARTICLE Provisionally accepted The full-text will be published soon. Notify me

Front. Pharmacol. | doi: 10.3389/fphar.2019.01139

Efficacy and Safety of Chinese Herbal Medicine for Primary Intracerebral Hemorrhage: A Systematic Review of Randomized Controlled Trials

  • 1Department of Neurology, Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical University, China
  • 2Institute of Clinical Pharmacology, Guangzhou University of Chinese Medicine, China

Abstract
Background: Primary intracerebral hemorrhage (ICH) is the most harmful subtype of stroke, but there have yet been no specific proven therapies. Chinese herbal medicine (CHM) has been used for ICH for more than thousand years; however currently it is still lack of available evidence. The objective of this study is to assess the current available evidence of CHM for acute ICH according to randomized controlled trials.
Methods: Eight databases were searched from their inception to November 2017. Only the studies that assessed at least 4 domains with ‘yes’ according to the Cochrane risk of bias tool were selected for analysis. All the data were analyzed by using Review Manager 5.3 software. P<0.05 was considered to be statistically significant.
Results: Forty-five studies with 4517 individuals were identified. CHM paratherapy can improve dependency, volume of hematoma, volume of perihematomal edema, clinical effective rate, and neurological function deficit compared CHM alone or placebo (all P<0.05). By contrast, it was not significant for improving mortality rate of ICH patients (p>0.05). In addition, adverse events were reported in 16 studies, whereas 29 studies did not mention it. The frequency of adverse events was 70/972 in the trial group and 48/944 in the control group.
Conclusion: The present study provided supportive evidence of CHM for improving dependency of ICH and showed generally safety; however, there is still lack of evidence for improving mortality rate, and it opens for further study.

Keywords: Primary intracerebral hemorrhage, Chinese herbal medicine (CHM), Systematic review, Meta-analaysis, Randomized controlled trials (RCT)

Received: 14 May 2019; Accepted: 04 Sep 2019.

Copyright: © 2019 Wang, Zeng, Xu, Zhou, Rong, Jin, Qi and Zheng. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence: Prof. Guo-qing Zheng, Department of Neurology, Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical University, Wenzhou, Zhejiang Province, China, gq_zheng@sohu.com