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Original Research ARTICLE Provisionally accepted The full-text will be published soon. Notify me

Front. Pharmacol. | doi: 10.3389/fphar.2019.01144

Detection of vasodilators from herbal components by a transcriptome-based functional gene module reference approach

 Li Peng1*,  Chang Chen2, Wuxia Zhang1, Dingrong Yu2, Shaoyan Liu3, Jinzhong Zhao1 and  An Liu2*
  • 1Shanxi Agricultural University, China
  • 2Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, China
  • 3China Academy of Chinese Medical Sciences, China

Vasodilatation is one of the key therapeutic strategies for the treatment of various cardiovascular diseases with high blood pressure. Therefore, development of drugs assisting blood vessel dilation is promising. It has been proved that many drugs display definite vasorelaxant effects. However, there are very few studies that systemically explore the effective vasodilators. In this work, we build a transcriptome-based functional gene module reference approach for systematic pursuit of agents with vasorelaxant effects. We firstly curate two functional gene modules that specifically involved in positive and negative regulation of vascular diameter based on the known gene functional interaction knowledge. Secondly, a collection of gene expression profiles following herbal component treatment are collected from public gene expression database. Then, the correlation of the gene modules is evaluated in each herbal component induced gene expression profile by gene set enrichment analysis. The vasorelaxant effects of the candidate compounds can be predicted and ordered by the values of a defined index. Finally, the top 10 candidate compounds are experimentally tested for their vasorelaxant effects on vessel contraction induced by phenylephrine in aortic rings. This strategy integrating different types of technologies is expected to help to create new opportunities for the development of novel vasodilators.

Keywords: Vasodilator, Herbal component, gene expression profile, Gene module, Drug Discovery

Received: 17 Jul 2019; Accepted: 04 Sep 2019.

Copyright: © 2019 Peng, Chen, Zhang, Yu, Liu, Zhao and Liu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence:
Prof. Li Peng, Shanxi Agricultural University, Jinzhong, China,
Prof. An Liu, Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing, China,