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Review ARTICLE Provisionally accepted The full-text will be published soon. Notify me

Front. Pharmacol. | doi: 10.3389/fphar.2019.01223

Comprehensive Review on Phytochemicals, Pharmacological and Clinical Potentials of Gymnema sylvestre

 Prof. Dr. Md Moklesur R. Sarker1, 2*,  Farzana Khan1,  Long Chiau Ming3, Isa N. Mohamed4,  Chao Zhao5 and Mohamed A. Rashid6
  • 1State University of Bangladesh, Bangladesh
  • 2Bangladesh Medical Research Council, Bangladesh
  • 3Faculty of Pharmacy, Quest International University Perak, Malaysia
  • 4Department of Pharmacology, Faculty of Medicine, National University of Malaysia, Malaysia
  • 5School of Food science, Fujian Agriculture and Forestry University, China
  • 6Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Dhaka, Bangladesh

Gymnema sylvestre is a plant included in Asclepiadaceae family and is located in many regions of Asia, Africa and Australia. This plant is used as a traditional therapy even now it is being used as a dietary supplement due to its numerous therapeutic potential. It is known to have sugar lowering potential in blood, thus is widely used in traditional and modern medicine system. It renders sugar lowering property due to the presence of phytochemicals such as gurmarin, gymnemic acid as well as gymnemasaponins. It is also known to have anti-oxidant, antibiotic, anti-inflammatory, antiviral, gastro and hepatoprotective, anticancer, lipid-lowering etc. activities. This review discusses in details on different pharmacological and clinical potentials of Gymnema sylvestre and its chemical constituents associated with its therapeutic potential.

Keywords: Gymnema sylvestre, antidiabetic, anticancer, Immunomodulating, Lipid lowering, anti-inflammatory, clinical studies, traditional medicine, Functional Food, nutraceutical, Phytonutrient

Received: 24 May 2019; Accepted: 23 Sep 2019.

Copyright: © 2019 Sarker, Khan, Ming, Mohamed, Zhao and Rashid. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence: Prof. Prof. Dr. Md Moklesur R. Sarker, State University of Bangladesh, Dhaka, 1205, Dhaka, Bangladesh, moklesur2002@yahoo.com