In the original article, there was a mistake in Table 1 as published. A previous version of the Table was published that was not revised and did not include updated references. The corrected Table 1 appears below.
Table 1
| LncRNA (size) | Mode of action | Function | Structure | Probing techniques | References |
|---|---|---|---|---|---|
| Xist (17,000 nucleotides) | cis | X-chromosome inactivation. | Regions A-F with distinct repeat sequences. | In vivo and in vitro SHAPE-MaP. Targeted structure Seq. PARIS | Simon et al., 2013; Fang et al., 2015; Lu et al., 2016; Smola et al., 2016 |
| RepA (1,600 nucleotides) | cis | Encoded by an internal promoter on the Xist gene sense strand. | Three folding modules. | In vitro using chemical probing with SHAPE and DMS reagents. | Liu et al., 2017a |
| Rox1 (3,700 nucleotides) Rox2 (1,200 nucleotides) | cis and trans | Male specific nuclear RNAs. Dosage compensation. | Rox1: three stable helices connected by flexible linker regions. Rox2: two clusters of tandem stem-loops. | In vitro using chemical probing with SHAPE and PARS analysis. Both methods independently support the rox2 structure model. | Ilik et al., 2013 |
| SRA (870 nucleotides) | trans | Interacts with SRA protein to regulate cardiac muscle differentiation. | Four distinct domains. | In vitro SHAPE and DMS chemical probing. Good agreement with RNase V1 enzymatic probing. | Novikova et al., 2012 |
| HOTAIR (2,148 nucleotides) | trans | Associated with sporadic thoracic aortic aneurysm and non-end stage heart failure. Circulating biomarker for acute myocardial infarction and congenital heart diseases. | Four structural modules. | In vitro using chemical probing with SHAPE and DMS reagents. | Somarowthu et al., 2015; Greco et al., 2016; Gao et al., 2017; Guo et al., 2017; Jiang et al., 2018 |
| Braveheart (590 nucleotides) | trans | Cardiovascular lineage commitment. | Three domains. Critical structure: a 5′ asymmetric G-rich internal loop (AGIL). | In vitro using chemical probing with SHAPE and DMS reagents. | Xue et al., 2016 |
Structural Determination of lncRNAs.
The authors apologize for this error and state that this does not change the scientific conclusions of the article in any way. The original article has been updated.
References
1
FangR.MossW. N.Rutenberg-SchoenbergM.SimonM. D. (2015). Probing Xist RNA structure in cells using targeted structure-Seq. PLoS Genet.11:e1005668. 10.1371/journal.pgen.1005668
2
GaoL.LiuY.GuoS.YaoR.WuL.XiaoL.et al. (2017). Circulating long noncoding RNA HOTAIR is an essential mediator of acute myocardial infarction. Cell Physiol. Biochem.44, 1497–1508. 10.1159/000485588
3
GrecoS.ZaccagniniG.PerfettiA.FuschiP.ValapertaR.VoellenkleC.et al. (2016). Long noncoding RNA dysregulation in ischemic heart failure. J. Transl. Med.14:183. 10.1186/s12967-016-0926-5
4
GuoX.ChangQ.PeiH.SunX.QianX.TianC.et al. (2017). Long non-coding RNA-mRNA correlation analysis reveals the potential role of HOTAIR in pathogenesis of sporadic thoracic aortic aneurysm. Eur. J. Vasc. Endovasc. Surg.54, 303–314. 10.1016/j.ejvs.2017.06.010
5
IlikI. A.QuinnJ. J.GeorgievP.Tavares-CadeteF.MaticzkaD.ToscanoS.et al. (2013). Tandem stem-loops in roX RNAs act together to mediate X chromosome dosage compensation in Drosophila. Mol. Cell51, 156–173. 10.1016/j.molcel.2013.07.001
6
JiangY.MoH.LuoJ.ZhaoS.LiangS.ZhangM.et al. (2018). HOTAIR is a potential novel biomarker in patients with congenital heart diseases. Biomed. Res. Int.2018:2850657. 10.1155/2018/2850657
7
LiuF.SomarowthuS.PyleA. M. (2017a). Visualizing the secondary and tertiary architectural domains of lncRNA RepA. Nat. Chem. Biol.13, 282–289. 10.1038/nchembio.2272
8
LuZ.ZhangQ. C.LeeB.FlynnR. A.SmithM. A.RobinsonJ. T.et al. (2016). RNA duplex map in living cells reveals higher-order transcriptome structure. Cell165, 1267–1279. 10.1016/j.cell.2016.04.028
9
NovikovaI. V.HennellyS. P.SanbonmatsuK. Y. (2012). Structural architecture of the human long non-coding RNA, steroid receptor RNA activator. Nucleic Acids Res.40, 5034–5051. 10.1093/nar/gks071
10
SimonM. D.PinterS. F.FangR.SarmaK.Rutenberg-SchoenbergM.BowmanS. K.et al. (2013). High-resolution Xist binding maps reveal two-step spreading during X-chromosome inactivation. Nature504, 465–469. 10.1038/nature12719
11
SmolaM. J.ChristyT. W.InoueK.NicholsonC. O.FriedersdorfM.KeeneJ. D.et al. (2016). SHAPE reveals transcript-wide interactions, complex structural domains, and protein interactions across the Xist lncRNA in living cells. Proc. Natl. Acad. Sci. U.S.A.113, 10322–10327. 10.1073/pnas.1600008113
12
SomarowthuS.LegiewiczM.ChillonI.MarciaM.LiuF.PyleA. M. (2015). HOTAIR forms an intricate and modular secondary structure. Mol. Cell58, 353–361. 10.1016/j.molcel.2015.03.006
13
XueZ.HennellyS.DoyleB.GulatiA. A.NovikovaI. V.SanbonmatsuK. Y.et al. (2016). A G-rich motif in the lncRNA braveheart interacts with a zinc-finger transcription factor to specify the cardiovascular lineage. Mol. Cell64, 37–50. 10.1016/j.molcel.2016.08.010
Summary
Keywords
non-coding RNA, lncRNA, RNA structure, gene editing, cardiovascular diseases
Citation
Zampetaki A, Albrecht A and Steinhofel K (2019) Corrigendum: Long Non-coding RNA Structure and Function: Is There a Link?. Front. Physiol. 10:1127. doi: 10.3389/fphys.2019.01127
Received
19 May 2019
Accepted
15 August 2019
Published
03 September 2019
Volume
10 - 2019
Edited by
Lacolley Patrick, Institut National de la Santé et de la Recherche Médicale (INSERM), France
Reviewed by
Alexandre Raoul, Université de Lorraine, France
Updates
Copyright
© 2019 Zampetaki, Albrecht and Steinhofel.
This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
*Correspondence: Anna Zampetaki anna.zampetaki@kcl.ac.uk
This article was submitted to Vascular Physiology, a section of the journal Frontiers in Physiology
Disclaimer
All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.