In the published article, there was an error in Figure 1 as published. In panel B, ALP staining pictures for R335Q and R377H were inadvertently mislabeled, which needs to be replaced. R335Q shows overlap with M1I, and R377H shows overlap with R541C. The corrected Figure 1 appears below.
FIGURE 1
Differentiation and characterization of induced pluripotent stem cell (iPSC)-derived cardiomyocytes (iCMs) and cardiac fibroblasts (iCFs). (A) Sanger sequencing validates the presence of the individual mutation. (B) Representative staining of iPSCs expressing pluripotency markers SOX2 (green) and TRA-1-60 (red), SSEA4 (green), OCT4 (red), and alkaline phosphatase. Nuclei were stained with DAPI (blue). (C) Schematic of cardiac differentiation using STEMdiff™ Cardiomyocyte Differentiation kit. (D) Immunostaining of cardiac troponin T positive cardiomyocytes. (E) Workflow to induce cardiac fibroblasts using small molecule-based protocols. (F) Immunostaining of cardiac fibroblast specific marker, vimentin. Scale bar, 100 μm.
The authors apologize for this error and state that this does not change the scientific conclusions of the article in any way. The original article has been updated.
Statements
Publisher’s note
All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article, or claim that may be made by its manufacturer, is not guaranteed or endorsed by the publisher.
Summary
Keywords
LMNA, dilated cardiomyopathy, induced pluripotent stem cell, cardiomyocytes, cardiac fibroblasts, connexin 43
Citation
Yang J, Argenziano MA, Burgos Angulo M, Bertalovitz A, Beidokhti MN and McDonald TV (2022) Corrigendum: Phenotypic variability in iPSC-induced cardiomyocytes and cardiac fibroblasts carrying diverse LMNA mutations. Front. Physiol. 13:974151. doi: 10.3389/fphys.2022.974151
Received
20 June 2022
Accepted
26 July 2022
Published
31 August 2022
Volume
13 - 2022
Edited and reviewed by
Xianming Lin, New York University, United States
Updates
Copyright
© 2022 Yang, Argenziano, Burgos Angulo, Bertalovitz, Beidokhti and McDonald.
This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
*Correspondence: Thomas V. McDonald, thomasmcdonald@usf.edu
This article was submitted to Cardiac Electrophysiology, a section of the journal Frontiers in Physiology
Disclaimer
All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.