Impact Factor 2.857

Frontiers journals are at the top of citation and impact metrics

Original Research ARTICLE Provisionally accepted The full-text will be published soon. Notify me

Front. Psychiatry | doi: 10.3389/fpsyt.2018.00609

Serum Markers of Inflammation Mediate the Positive Association between Neuroticism and Depression

  • 1Department of Psychiatry and Psychotherapy, Universitätsklinikum Leipzig, Germany
  • 2Department of Psychological Medicine, King's College London, United Kingdom
  • 3Institute of Laboratory Medicine, Ludwig-Maximilians-Universität München, Germany

Background: The personality trait neuroticism has been implicated in a poor response to stress, may relate to increased concentrations of cytokines and the development of depression. Inflammatory mechanisms may also be associated with the onset, severity and symptoms of depression. Both are related to poor antidepressant treatment outcome. Therefore, mediators of inflammation may bridge the relationship between neuroticism and depression.
Methods: To disentangle these interrelationships, the associations between neuroticism (according to NEO-PIR-N), depressive symptoms (BDI-II scores) and serum levels of hsCRP, TNF-α, IFN-γ, IL-2, IL-4, IL-5, IL-10, IL-12, IL-13, GM-CSF were investigated in 212 depressed (n=37) and non-depressed (n=175) participants. A mediation model was used to investigate whether the impact of neuroticism on depressive symptoms may be mediated by cytokines.
Results: Regression analyses revealed that IFN-γ, IL-5, and IL-12-levels, but none of the anti-inflammatory cytokines, were associated with the overall neuroticism score and several of the cytokines were related to the different facets of neuroticism. TNF-α, IFN-γ, IL-5, IL-12, and IL-13 were further related to the severity of depressive symptoms, as well as the somatic-affective and the cognitive dimensions of depression. Pro-inflammatory IFN-γ, IL-5 and IL-12 were identified as mediators of the positive prediction of depression severity by the degree of neuroticism.
Conclusions: The current findings demonstrate that conditions related to long-term stress, such as depression and high neuroticism, are related to an up-regulation of inflammatory agents. Neuroticism may increase stress perception and, thus, increase the production of pro-inflammatory messenger molecules which are invloved in the development of depression. This evidence may contribute to future anti-inflammatory interventions, particularly in subjects with high neuroticism who are at risk for developing depression. Furthermore, depressed patients may require early escalations in the intensity of treatment, along with additional therapeutic elements to increase the rate of treatment success.

Keywords: personality trait, chronic stress, Cytokines, TNF-α, mediation analyses, Depression, neuroticism, Inflammation

Received: 10 Aug 2018; Accepted: 30 Oct 2018.

Edited by:

Gianluca Serafini, Dipartimento di Neuroscienze e Organi di Senso, Ospedale San Martino (IRCCS), Italy

Reviewed by:

Catherine Toben, University of Adelaide, Australia
Atsuo Nakagawa, School of Medicine, Keio University, Japan  

Copyright: © 2018 Schmidt, Sander, Minkwitz, Mergl, Dalton, Holdt, Teupser, Hegerl and Himmerich. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence: Dr. Frank M. Schmidt, Universitätsklinikum Leipzig, Department of Psychiatry and Psychotherapy, Leipzig, Germany,