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Early Life Stress and Depression

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Front. Psychiatry | doi: 10.3389/fpsyt.2019.00172

The interaction of TPH2 and 5-HT2A polymorphisms on major depressive disorder susceptibility in a Chinese Han population: a case-control study

Jiarun Yang1, Xueyan Zhao1, Jingsong Ma1, Zhengxue Qiao1, Xiuxian Yang1, Erying Zhao1, Bo Ban2,  Xiongzhao Zhu3, Depin Cao1,  Yanjie Yang1* and Xiaohui Qiu1
  • 1Harbin Medical University, China
  • 2Affiliated Hospital of Jining Medical University, China
  • 3Medical Psychological Center, Second Xiangya Hospital, Central South University, China

Purpose: TPH2 and 5-HT2A appear to play vital roles in the homeostatic regulation of serotonin levels in the brain, their genetic variations may lead to impaired homeostatic regulation of serotonin resulting in abnormal levels of serotonin in the brain, thus predisposing individuals to MDD. However, research studies have yet to confirm which gene-gene interaction effect between TPH2 and 5-HT2A polymorphisms results in increased susceptibility to MDD.
Methods: A total of 565 participants, consisting of 278 MDD patients and 287 healthy controls from the Chinese Han population, were recruited for the present study. Six single nucleotide polymorphisms (SNPs) of TPH2/5-HT2A were selected to assess their interaction by use of a generalized multifactor dimensionality reduction method.
Results: A-allele carriers of rs11178997 and rs120074175 were more likely to suffer from MDD than T-allele carriers of rs11178997, or G-allele carriers of rs120074175. The interaction between TPH2 (rs120074175, rs11178997) and 5-HT2A (rs7997012) was considered as the best multi-locus model upon the MDD susceptibility.
Conclusions: Our data identified an important effect of TPH2 genetic variants (rs11178997 and rs120074175) upon the risk of MDD, and suggested that the interaction of TPH2/5-HT2A polymorphism variants confer a greater susceptibility to MDD in Chinese Han population.

Keywords: Major Depressive Disorder, TPH2, 5-HT2A, gene-gene interaction, polymorphisms

Received: 16 Sep 2018; Accepted: 08 Mar 2019.

Edited by:

Fushun Wang, Nanjing University of Chinese Medicine, China

Reviewed by:

Taolin Chen, West China Hospital, Sichuan University, China
Jianyou Guo, Institute of Psychology, Chinese Academy of Sciences, China  

Copyright: © 2019 Yang, Zhao, Ma, Qiao, Yang, Zhao, Ban, Zhu, Cao, Yang and Qiu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence: Prof. Yanjie Yang, Harbin Medical University, Harbin, China,