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Original Research ARTICLE Provisionally accepted The full-text will be published soon. Notify me

Front. Psychiatry | doi: 10.3389/fpsyt.2019.00572

Classification of Early and Late Mild Cognitive Impairment Using Functional Brain Network of Resting-State fMRI

 Tingting Zhang1, Zanzan Zhao1, Chao Zhang1,  Junjun Zhang1,  Zhenlan Jin1,  Ling Li1* and for the A. Neuroimaging Initiative2
  • 1University of Electronic Science and Technology of China, China
  • 2Alzheimer’s Disease Neuroimaging Initiative, United States

Using the Pearson correlation coefficient to constructing functional brain network has been evidenced to be an effective means to diagnose different stages of mild cognitive impairment (MCI) disease. In this study we investigated the efficacy of a classification framework to distinguish early mild cognitive impairment (EMCI) from late mild cognitive impairment (LMCI) by using the effective features derived from functional brain network of three frequency bands (full-band: 0.01-0.08Hz; slow-4: 0.027-0.08Hz; slow-5: 0.01Hz-0.027Hz) at rest. Graphic theory was performed to calculate and analyze the relationship between changes in network connectivity. Subsequently three different algorithms (minimal redundancy maximal relevance (mRMR), sparse linear regression feature selection algorithm based on stationary selection (SS-LR), Fisher Score (FS)) were applied to select the features of network attributes, respectively. Finally, we used the support vector machine (SVM) with nested cross validation to classify the samples into two categories to obtain unbiased results. Our results showed that the global efficiency, the local efficiency and the average clustering coefficient were significantly higher in the slow-5 band for the LMCI–EMCI comparison, while the characteristic path length was significantly longer under most threshold values. The classification results showed that the features selected by the mRMR algorithm have higher classification performance than those selected by the SS-LR and FS algorithms. The classification results obtained by using mRMR algorithm in slow-5 band are the best, with 83.87% accuracy (ACC), 86.21% sensitivity (SEN), 81.21% specificity (SPE), and the area under receiver operating characteristic curve (AUC) of 0.905. The present results suggest that the method we proposed could effectively help diagnose MCI disease in clinic and predict its conversion to Alzheimer’s disease at an early stage.

Keywords: Resting-state fMRI, Mild Cognitive Impairment, Feature Selection, functional network, Classification

Received: 05 Mar 2019; Accepted: 22 Jul 2019.

Copyright: © 2019 Zhang, Zhao, Zhang, Zhang, Jin, Li and Neuroimaging Initiative. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence: Prof. Ling Li, University of Electronic Science and Technology of China, Chengdu, 610054, Sichuan Province, China,