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Original Research ARTICLE Provisionally accepted The full-text will be published soon. Notify me

Front. Psychiatry | doi: 10.3389/fpsyt.2019.00658

Epilepsy and Autism Spectrum Disorder: An Epidemiological Study in Shanghai, China

 Anyi Zhang1, 2, Jijun Li2, Yiwen Zhang1, 2, Xingming Jin1, 2 and  Jun Ma1, 2*
  • 1Shanghai Children's Medical Center, China
  • 2Shanghai Jiao Tong University, China

Autism spectrum disorder (ASD) is a neurodevelopmental disease that may involve various brain abnormalities. However, there are few large epidemiological studies on the relation between epilepsy and ASD in terms of different gender and age. This study aimed to evaluate the relation between epilepsy and ASD based on 74,251 Chinese children aged 3-12 years who were recruited from kindergartens and primary schools in China. ASD was diagnosed according to the DSM-V, and verification of epilepsy was based on medical records. The enrolled children diagnosed with ASD were examined by MRI and took genetic tests to rule out other neurological and congenital diseases. The raw odds ratio (OR) was 60.53 (95% CI = 37.80-96.92, P<0.01) for epilepsy and ASD, and the adjusted OR was 38.99 (95% CI = 20.70-73.41, P<0.01) after controlling the confounders. Moreover, the adjusted OR was significantly higher in girls (OR = 45.26, 95% CI = 16.42-124.76, P<0.01) than in boys (OR = 32.64, 95% CI = 14.33-74.34, P<0.01). Among children with younger age, the adjusted OR was the highest (OR = 75.12, 95%CI = 22.80-247.48.16, P<0.01). These findings suggested that epilepsy might be closely linked to the development of ASD, especially for the early onset epilepsy and among girls.

Keywords: Autism Spectrum Disorder, age, Epilepsy, gender, social function neural network

Received: 23 Jul 2018; Accepted: 14 Aug 2019.

Edited by:

Xiaohong Li, Institute for Basic Research in Developmental Disabilities (IBR), United States

Reviewed by:

Catherine Saint-Georges,
Tong Xu, Second Military Medical University, China  

Copyright: © 2019 Zhang, Li, Zhang, Jin and Ma. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence: Dr. Jun Ma, Shanghai Children's Medical Center, Shanghai, Shanghai Municipality, China, majun@shsmu.edu.cn