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Front. Psychiatry | doi: 10.3389/fpsyt.2019.00786

A Brief Review of Paradigm Shifts in Prevention of Alzheimer’s Disease: from Cognitive Reserve to Precision Medicine

  • 1Daejeon St. Mary’s Hospital, Catholic University of Korea, South Korea
  • 2Seoul St. Mary's Hospital, The Catholic University of Korea, South Korea

Alzheimer’s disease (AD) and related dementias can be an enormous economic burden for taxpayers, patients, their families, medical systems and society as a whole. Since disease-modifying treatments have failed, several studies have instead focused on a paradigm shift for preventing and treating Alzheimer’s disease. A higher cognitive reserve (e.g., greater education, occupational attainment, or more leisure activities) is associated with protection against disease-related cognitive decline. Precision medicine aims to optimize the effectiveness of disease prevention and treatment by considering specific biological components of individuals. We suggest that research into cognitive reserve and precision medicine could be a key to overcoming the limitations of traditional approaches to the prevention and treatment of AD.

Keywords: Alzheimer’s disease, Cognitive Reserve, precision medicine, prevention, Aging, biomarkers

Received: 07 Apr 2019; Accepted: 02 Oct 2019.

Copyright: © 2019 Hahn and Lee. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence: Prof. Chang Uk Lee, Seoul St. Mary's Hospital, The Catholic University of Korea, Seoul, Seoul, South Korea,