ORIGINAL RESEARCH article
Stress and Simulated Environments: Insights From Physiological Marker
- 1Department of General Psychology: Cognition, University of Duisburg-Essen, Duisburg, Germany
- 2Erwin L. Hahn Institute for Magnetic Resonance Imaging, Essen, Germany
- 3Department of Mechatronics, University of Duisburg-Essen, Duisburg, Germany
Driving in a simulator might induce stress because of the confrontation with new environments, dealing with new technologies, and experience with symptoms of simulator sickness, which, in turn, may influence individuals’ driving performance. The present study aims to provide a better understanding of the association between simulated environments and humans’ stress level under consideration of age, simulator adaptation, experience with simulator sickness, and driving performance. Data from 164 participants (M = 61.62 years, SD = 12.66 years, ranging from 25 to 89 years, 42 women) were analyzed in the present study. During three measurement times, participants completed an advance first simulator drive (T0), followed by an online survey, assessing experience with simulator sickness (T1), and a second simulator drive (T2) including pre- and post-cortisol measurements. The hypothesized model shows no correlations of driving performance with experience with simulator sickness or stress level before and after a further simulator drive. Beyond the effect of age, previous experience with simulator sickness does further account for stress-level changes following a simulated drive but current driving performance did not. The present study provides relevant findings for future studies in the field of simulated environments.
Stress can negatively affect humans’ behavior, in learning and memory (e.g., Schwabe et al., 2008; Wolf, 2009; Wolf, 2019), decision-making (e.g., Gathmann et al., 2014), and also driving (e.g., Rimini-Doering et al., 2001). In the past, studies frequently highlighted negative effects of stress on driving performance as well as on accident rate (e.g., Matthews, Dorn et al., 1998; Rimini-Doering et al., 2001). While driving is most frequently investigated in simulated environments and previous findings indicate a relation between the usage of new technologies and stress induction (e.g., Thomée et al., 2007), it seems inevitable to consider the possibility of simulator-induced stress. Therefore, the present study aims to provide a better understanding of the relation between simulated environments and the human stress level under consideration of individual factors, simulator adaptation, and previous experience with simulator sickness, within a driving simulator.
Driving a car activates several brain regions, such as the prefrontal cortex (Jäncke et al., 2008) and the basal ganglia (Uchiyama et al., 2003), both of which are affected by a stress-induced increase in the level of catecholamines and/or cortisol (Cohen et al., 2002; Nieoullon, 2002; Ramos and Arnsten, 2007; Cabib and Puglisi-Allegra, 2012). To quantify acute psychophysiological effects of driving, Yamaguchi and Sakakima (2007) measured salivary alpha-amylase prior to and every 3 min during a 21-min simulated drive. Results indicated a significant increase in stress level during the driving period, compared to the baseline measure. Along with the assessment of alterations in endocrine activity, heart rate is frequently used as a biomarker to investigate individuals’ stress level. For example, Ashton et al. (1972) reported a relation between heart rate and difficulty of driving scenarios. Their results are supported by findings from flight simulator studies (e.g., Roscoe, 1992; Ylönen et al., 1997; Lee and Liu, 2003). For example, Lee and Liu (2003) identified an increased heart rate during flight phases with high information load, such as take-off and landing, compared to phases with lower information load.
Comparisons of simulated and real scenarios reported no differences in the ‘Driving Behaviour Inventory’ (Gulian et al., 1989; Matthews et al., 1991; Dorn and Matthews, 1995). In contrast, Engström et al. (2005) identified increased stress reactions in real, compared to simulated driving, quantified by physiological parameters. The authors discussed an indication of increased effort due to a higher risk in real scenarios compared to simulated scenarios as responsible for the effects. Their findings are confirmed by Johnson et al. (2011), who reported significantly higher means of heart rate in on-road vs. simulated driving. However, Reimer and Mehler (2011) showed similar patterns of heart rate and electrodermal arousal with increased cognitive workload in simulated driving compared to on-road driving but with higher absolute levels in the real world.
In addressing the topic of simulator-related stress, the phenomenon of simulator sickness needs to be considered. During recent years, studies showed simulator sickness–related dropout rates between 5 and 30% (Stanney et al., 1998; Cobb et al., 1999; Stanney et al., 2002). Based on previous findings, it can be assumed that the onset of simulator sickness can trigger stress. For example, Eversmann et al. (1978) reported a stimulation of hormone secretion induced by different degrees of motion sickness. Additionally, the authors identified the secretion of antidiuretic hormones as the most sensitive indicator of motion sickness–induced stress. Further evidence for a relation between motion sickness and stress comes not only from the glucocorticoid/symphaticoadrenergic system (Otto et al., 2006) but also from the endocannabinoid system (Choukèr et al., 2010). Furthermore, the sole anticipation of a stressful event induces stress, as indicated by previous stress studies. Here, results show that simply instructing participants to give a public speech is a common method for inducing stress in laboratory investigations (Levenson et al., 1980; Starck et al., 2008), leading to increased anxiety and negative mood (Al’Absi et al., 1997) and increased cortisol level (Dickerson and Kemeny, 2004; Juster et al., 2012). Interestingly, higher anticipatory stress may also be associated with a larger decrease in cortisol level during stress recovery (Juster et al., 2012). Based on these findings, it can be assumed that previous experiences with simulator sickness may influence the stress level before further simulator usages, in terms of anticipatory stress.
Simulator adaptation reflects the process by which drivers adapt their existing driving skills to the simulator (Sahami et al., 2009) and is related to the occurrence of simulator sickness. Domeyer et al. (2013) indicated that using an initial acclimation to the driving simulator reduces symptoms of simulator sickness. Together with findings from simulator/motion sickness studies, it can be hypothesized that a previous adaptation to the simulated environment decreases the stress level before subsequently using a simulator, compared to individuals who did not adapt. This is in line with the allostatic load model—introduced by Sterling and Eyer (1988)—which claims that stress mainly arises from mental and physical adaptation to novel and changing conditions (see also Sterling, 2012). In these situations, allostatic describes the process by which the body maintains its stability through behavioral changes (McEwen, 1998; McEwen, 2010).
A further aspect that should be considered in the present context concerns age-effects. Previous simulator studies indicated decreased driving performance (e.g., Andrews and Westerman, 2012), increased risk of accidents (e.g., Lee et al., 2003b), and increased mental workload (e.g., Cantin et al., 2009) in older compared to younger drivers. While Lee et al. (2003a) demonstrated the comparability of on-road and simulated driving in quantifying older adults driving performance, Matthews et al. (1999) indicated higher stress level in older adults, compared to their younger counterparts during a simulated driving. Reimer et al. (2006) report higher workload impact in older vs. younger drivers during a simulator driving task. A possible explanation comes from Aldwin (1991), who argues that older adults are perceived to have less control over their environment than younger adults and therefore show a higher stress level. Further studies report increased symptoms of simulator sickness (Classen et al., 2011) as well as a decreased simulator adaptation rate (Domeyer et al., 2013) in older compared to younger adults. According to the allostatic load model, increased stress stems from a higher load necessary in order to adapt to a novel environment or changing condition. This might further explain age-related differences in simulator tasks, since older adults report increased problems with new technologies (Kang and Yoon, 2008; Findlater et al., 2013).
With respect to the reported findings, we conducted a hypothetical model, which is the subject of investigation in the study at hand (Figure 1).
Besides the statistical testing of the hypothetical model, we further aimed at investigating the hypothesis that individuals who had previously adapted to a simulator show lower pre-stress to a subsequent simulator use than individuals who had not adapted.
The present study comprises findings from three measurement times: an advance simulator drive (T0), followed by an online survey assessing symptoms of experienced simulator sickness (T1), and the stress assessment and simulator drive (T2) including a second simulator drive and pre- and post-cortisol measurements. The study at hand is part of a 3-year interdisciplinary research project (ALFASY) funded by the European Regional Development Fund (ERDF.NRW) of the European Union and the State of North Rhine–Westphalia. The project aims to further develop age-based driver assistance systems. The medical check and the baseline investigation (T0) serve for the main project. The current study reports on data that were collected to answer specific research questions, independently of the main project. Further results out of sub-studies from the project are published elsewhere: subjective vs. objective adaptation (Brandtner et al., 2019), driving performance and specific attentional domains (Liebherr et al., 2019), and mental abilities and demographic parameters on simulator adaptation (Liebherr et al., 2020).
Before starting, participants carefully read the instructions and gave written informed consent to participation. Prior to the first simulator drive (T0), participants were medically examined to ensure simulator suitability (e.g., heart rate and assessment of current diseases). After a 10 min break, they received instructions on how to use the simulator. They were informed that they can stop driving at any time in case they feel sick or in case they want to cancel for any other reason. If there were no questions left, participants started the 25-min simulator driving. In order to quantify intensity of simulator sickness symptoms, participants received an e-mail instructing them to conduct an online version of the simulator sickness questionnaire (Brooks et al., 2010). The e-mail was sent 5 days after the first simulator drive (T1), to ensure that symptoms that occur after the experiment are also considered. Completing the questionnaire took about 10 min. Approximately 12 weeks after the first drive, participants visited our laboratory again and completed a further simulator driving task (T2). Before participants entered the driving simulator, a first salivary sample was taken (pre-cortisol measurement). After 20 min of driving, participants had a 5 min break before completing another 20 min of driving in the simulator. Immediately afterward, the second salivary sample was taken (post-cortisol measurement) (see also Figure 2 for a description of the study setup).
Originally, 458 individuals (M = 59.45 years, SD = 15.02 years, ranging from 19 to 89 years, 169 women) met the inclusion criteria and took part in T0. Participants reported not to have any neurological or cardiovascular diseases, nor impairments in the abilities to see or hear. Furthermore, individuals did not show any signs of dementia or cognitive decline as indicated by scores below nine in the ‘DemTect-Test’ (Kessler et al., 2000; Kalbe et al., 2004). However, in total 294 participants were excluded from further analyses because they either 1) stopped the baseline testing due to simulator sickness (see Figure 3), 2) did not participate in T1 or T2, or 3) salivary cortisol samples could not be analyzed.
FIGURE 3. Distribution of driving time regarding the age of participants at baseline driving (T0). Those who did not complete the baseline scenario stopped because of symptoms of simulator sickness.
The final sample consisted of 164 participants (M = 61.62 years, SD = 12.66 years, ranging from 25 to 89 years, 42 women). The study was performed in accordance with the ethical standards laid down in the Declaration of Helsinki. A local ethics committee approved the study. All participants provided written informed consent prior to each of the experiments and were informed that they could end participation at any time without reprisal.
The simulator consists of a close-to-real vehicle of the compact class, which has been extended by force feedback components for the simulation of forces and torques. The vehicle is positioned in a rectangular ‘cave’ without a movement platform (see Figure 4A for an illustration). The simulated environment is projected on the inner walls of the cave and presented on screens in each of the side mirrors. In addition, behind the rear window of the vehicle, a monitor is placed, which is used for both the rear view and the reflection of the image in the interior mirror. For simulating a realistic driving behavior, the driver inputs are read by means of the vehicle CAN bus and used as inputs of a complete vehicle simulation (cf., Maas et al., 2014). Furthermore, road users are represented in the vehicle environment who interact with the simulated vehicle (see Maas, 2017). The baseline driving scenario (T0) consisted of a 3 × 3 km area with inner-city roads, rural roads, and highways (see Figure 4B for an overview). The total length of 70 km is merged into several loops to provide an infinite scenario without dead ends. The second driving scenario (T2) consisted of the same scenario but limited to the highway only. To ensure a most realistic driving scenario, we did not include any predefined routes or preceding cars which the participants should follow.
FIGURE 4. (A) Schematic representation of the driving simulator used. The four projectors on the ceiling display the virtual environment on the walls around the vehicle. The monitor behind the vehicle is used for both the rear view and the reflection of the image in the interior mirror. (B) Sketch of the baseline driving scenario consisting of inner-city roads, rural roads, and highways. The driving scenario in T2 used the same scenario but limited to highway only.
Within the baseline scenario (T0), driving performance was quantified only for determining the time of adaptation. While previous simulator studies with mixed road-scenarios (rural roads and freeways) measured driving performance by considering only single driving parameters, we used the index of performance (IOP), calculated by Joshi’s algorithm (Joshi et al., 2017). The IOP contains numerous criteria that provide information on driving performance (steering behavior, activity of the pedals, and lane drifts) which are considered to the same extent. During unconventional driving—such as large steering movements or pushing the accelerator and brake pedals to their end position—the IOP increases. As soon as the participant had adapted to the system, the IOP stagnates or decreases. To identify the time of adaptation, the IOP and its gradient were calculated and graphically displayed using ‘MATLAB’. Figure 5 shows an example of the driving performance (measured by the IOP) of a person who has adapted to the simulator and one who has not. Driving performance at T2 was calculated by using the IOP, but without pedal activity since it is negligible in quantifying driving performance on highways. Therefore, the IOP at T2 (reflecting driving performance at T2) comprised means of steering movements and lane drifts only. It has to be mentioned that a higher IOP indicates worse driving performance.
FIGURE 5. Two examples of driving performances measured by individual IOP. Participant in panel (A) adapted to the simulator after about 400 s, whereas panel (B) did not.
Simulator Sickness Questionnaire
In the online survey (T1), we used the Simulator Sickness Questionnaire with a ten-stage intensity scale, ranging from 0 “none” to 10 “severe” (Brooks et al., 2010). In addition to the 16 symptoms comprised in the questionnaire, we added “vomiting” as additional symptom. The questionnaire was used as an online version. The sum score across the intensity of all symptoms was calculated as measure of simulator sickness experience.
We collected endocrine indicators of stress by sampling salivary cortisol concentrations before and after driving in the simulator a second time (T2). A rise of cortisol concentration indicates the stress response due to HPA axis activity (see Dickerson and Kemeny 2004). Salivary cortisol was assessed by means of unstimulated saliva samples obtained using Salivette collection devices (Sarstedt, Nuembrecht, Germany). The analyses of the individual cortisol levels from the saliva samples were performed by the Genetics Laboratory of the Ruhr-University Bochum (Germany). Interassay and intraassay variations were below 10%. Differences between pre- and post-cortisol levels were calculated by subtracting the first from the second cortisol level, with scores >0 representing an increase and scores <0 representing a decrease of the stress level after simulated driving.
The statistical analyses were carried out by using SPSS 25.0 for Windows (IBM SPSS Statistics). Pearson correlations were calculated to test the bivariate relationships between the variables. We used the Process Macro for SPSS (Hayes, 2017) to test model hypotheses. To test group differences between individuals who had adapted and those who had not adapted in the advance simulator driving scenario, regarding the pre-stress cortisol level before the second driving scenario, we applied a t test for independent samples. The critical level for statistical significance was set to 0.05 for all p values. For the indirect effects, significance was supposed if the 95% confidence interval did not include zero.
Description and Correlations
The mean age, the score of simulator sickness experience, and cortisol levels and their bivariate correlations can be found in Table 1. In contrast to previous findings (e.g., Garcia et al., 2010), we identified no gender differences in symptoms of simulator sickness (men: M = 3.36, SD = 2.65; women: M = 3.16, SD = 2.68; t (162) = 0.42, p = 0.677).
TABLE 1. Descriptive statistics and bivariate correlations between age, simulator sickness experience, pre-cortisol level a difference in cortisol level (post–pre), and driving performance.
Driving performance (T2) correlated with age but not with simulator sickness experience related to T1 nor with measures of stress (T2). Furthermore, simulator sickness experience solely correlated with difference in cortisol level. Therefore, the conditions for testing our originally hypothesized model were not met. We additionally tested correlations with mean driving speed (M = 105.48, SD = 18.94), which is not reflected in the IOP, as this parameter is discussed to decrease in response to internal and external stimuli (Matthews, 1996; Matthews et al., 1999). However, findings are replicated as we identified a significant correlation solely between age and mean driving speed (r = −0.341, p < 0.001).
Based on the theoretical background of the original model, we alternatively tested potential interaction effects between a) age × driving performance and b) age × simulator sickness experience on the difference in stress levels (post–pre cortisol levels). Therefore, we applied two hierarchical moderated regression analyses with age (predictor) in the first step, a) driving performance (IOP) and b) simulator sickness experience (moderators), respectively, in the second step, and the interaction term in the third step; the difference in cortisol level (post–pre) was the dependent variable (all variables are centralized, Cohen et al., 2003).
Hierarchical Moderated Regression Analyses
In the first step, age did lead to a significant explanation of differences in cortisol levels [R2 = 0.029, F (1,162) = 5.914, p = 0.016]. Adding driving performance in the second step did not lead to a significant increase of variance explanation [ΔR2 = 0.006, ΔF (1,161) = 0.954, p = 0.330] and neither did the interaction of age and driving performance in the third step [ΔR2 = 0.003, ΔF (1,160) = 0.474, p = 0.492]. The overall model accounted for 2.6% of the variance in cortisol-level change (F = 2.439, p = 0.492). The second analysis, including simulator sickness experience, revealed a significant additional explanation of variance (beyond the effect of age) in cortisol-level difference of nearly 10% [ΔR2 = 0.073, ΔF (1,161) = 13.097, p < 0.001]. In the third step, the interaction between age and simulator sickness experience was not significant [ΔR2 = 0.014, ΔF (1,160) = 2.470, p = 0.118]. The overall model was significant, accounting for 10.5% of the variance in difference in cortisol level before and after simulator drive (F = 7.366, p < 0.001).
Effects of Previous Simulator Adaptation
Mean pre-cortisol level (second scenario) of participants who had reported previous simulator adaptations (T0) showed slightly decreased pre-cortisol levels (M = 16.55, SD = 11.70) before the second driving scenario (T2) compared to participants who had not adapted previously (M = 17.67, SD = 14.39). However, this difference was not statistically significant [ t (160) = 0.493, p = 0.623].
The present study aimed to provide a better understanding of the relations between stress and simulated environments. Although the original hypothetical model could not be confirmed, the present study identified highly relevant findings that can be summarized as follows:
• Driving performance correlates with age but not with stress level nor with previous experience with simulator sickness.
• Age and previous experiences with simulator sickness predict stress-level changes following a simulated drive.
• Beyond the effect of age, driving performance does not further account for stress-level changes following a simulated drive.
• Individuals who had previously adapted to a simulator and those who had not do not differ in pre-cortisol level of a further simulator drive.
The present findings could not confirm any association of previous simulator sickness experience neither with the stress level before a subsequent simulator drive nor with driving performance. This is in accordance with previous findings, showing that cyber sickness does not necessarily cause anxiety or discomfort with virtual realities (Von Mammen et al., 2016). However, Clapp et al. (2011) indicated an interaction effect between self-reported stress history and anxious driving behavior. In addition, Jeon et al. (2011), who tested the effects of specific negative emotions on driving performance, identified more driving errors for anger than for fear. Previous findings on a relation between stress and behavior could not be confirmed in the present context (Westman and Eden, 1996; Struthers et al., 2000; Siu, 2003). However, it is remarkable that pre-stress level did not correlate with driving performance, albeit the pre-cortisol level is similar to those reported after inducing stress by the most commonly used method, the Trier Social Stress Test (Wolf et al., 2001). The missing effect might be explained by the relatively simple driving scenario in T2 (highway-driving with long straights and smooth curves) and therefore a low variance in driving performance. It can be further assumed that more complex scenarios, such as inner-city routes, would increase the effect of stress on driving performance, as reported by Matthews et al. (1998). The authors described effects of stress on driving performance depending not only on the nature of driver’s stress reactions but also on the traffic environment. Furthermore, Hill and Boyle (2007) identified a relation between not only stress and driver characteristics but also the driving environment. The aspect of environmental characteristics together with the fact that participants were able to freely choose how to drive, without a preceding car, might also explain the missing effect between driving performance and the post-/pre-cortisol level difference.
Prior to the study, we assumed that individuals who previously reported a simulator adaption would show lower pre-cortisol levels of a subsequent simulator drive, compared to those who did not adapt. However, the present findings demonstrate no effects. Here, the relatively long time interval between the baseline drive (T0) and the subsequent drive (T2) must be discussed to potentially be responsible for the missing effect. While previous studies with a repeated use of driving simulators used relatively short intervals (Cooper and Strayer, 2008; Thapa et al., 2015; Large et al., 2017), we used a time interval of approximately 12 weeks between the two simulator investigations. The relevance of the time interval between a training session and the later performance is additionally highlighted in studies on cognitive trainings. For example, Arthur et al. (1998) summarized in their meta-analysis a relatively large decrement in performance, 28–90 days after skill or knowledge trainings. In addition, Arthur et al. (2010) reported a significantly improved task-performance from pre- to post-training (56 days after completing the training) solely in the long-period training group, but not in the short-period training group. In accordance with Roenker et al. (2003), who identified no significant effect of a baseline simulator training on an 18 month later testing score, it can be suggested that the time between the baseline measure and the second measure was too long to produce transfer-effects of simulator adaptation.
Accordingly with previous findings we identified a correlation between age and driving performance. These effects are discussed in terms of numerous aspects, such as vision, motor functions, and also cognitive abilities (e.g., Wood, 2002; Anstey et al., 2005). Furthermore, previous findings on differences in stress and related coping strategies in older adults compared to younger were replicated by a direct effect of age on differences in cortisol level (Folkman et al., 1987; Diehl et al., 1996). This can be explained by the allostatic load model and also empirical findings on age-related differences in simulator tasks, who reported increased problems with new technologies in the elderly (Kang and Yoon, 2008; Findlater et al., 2013).
Based on its relevance, future studies should additionally investigate further individual attributes and conditions of the driver such as fatigue, drowsiness, or emotional status (e.g., Thiffault and Bergeron, 2003). In addition, future studies should consider further physiological measures (e.g., heart rate) and also subjective assessments of stress (e.g., questionnaires), to provide a broader insight into the effects of stress.
The fact that we focused exclusively on individuals who completed the baseline scenario, as only these could be invited to the second scenario, constitutes another limitation of the study at hand. Participants who stopped the baseline scenario prematurely (because of simulator sickness) were excluded from the study and thus not included in analyzing stress reactions in subsequently driving in the simulator. Based on the high numbers of simulator sickness induced dropouts (e.g., Stanney et al., 2002), future studies should explicitly focus on this group of individuals. Furthermore, in the study at hand, participants who completed the first drive were asked to evaluate online their symptoms of simulator sickness 5 days after the first simulator drive. This procedure was based on previous findings that identified lasting effects of the symptoms up to one week or longer (Ungs, 1987). However, for future studies, we recommend applying the simulator sickness questionnaire twice (subsequently afterward and a few days later) in order to avoid biases in intensity recall and to make it more comparable to general protocols.
Present findings need to be discussed under consideration of the driving scenario. Here, we used solely a highway scenario for the second testing in the simulator. However, it can be assumed that more complex driving scenarios with different environments such as inner-city roads or rural roads (e.g., Ronen and Yair, 2013) and also different conditions such as day, night, rain, or fog (e.g., Konstantopoulos et al., 2010) would lead to different findings and, therefore, should be tested in future studies.
Despite the limitations and the partially contradictory results, the present study provides relevant findings for future simulator studies. Especially, the findings of a missing relation between previous experience with simulator sickness symptoms (in participants who completed the baseline testing) and further simulator driving performance seems to be relevant for future studies. Accordingly, previous experience with simulator sickness does not need to be an exclusion criterion for participating in future simulator studies as it does not seem to have significant effects on participant’s performance or level of stress. Rather, age can be considered a relevant influencing factor. Among others, this aspect should be considered further with regard to varying time intervals between different measurements as well as regarding participants who do not finish the baseline testing because of simulator sickness.
Data Availability Statement
The raw data supporting the conclusions of this article will be made available by the authors, without undue reservation.
The studies involving human participants were reviewed and approved by the ethics committee of the division of Computer Science and Applied Cognitive Sciences at the Faculty of Engineering. The patients/participants provided their written informed consent to participate in this study.
All authors were equally involved in the conception of the study. DS and MB came up with the project idea and accompanied the study as supervisors. ML and SM were responsible for neuropsychological testing and stress measurement. NM and SS were responsible for the investigations in the simulator. Everyone was equally involved in the writing of the manuscript.
Conflict of Interest
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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Keywords: simulator sickness, aging, stress, simulated environment, driving performance
Citation: Liebherr M, Mueller SM, Schweig S, Maas N, Schramm D and Brand M (2021) Stress and Simulated Environments: Insights From Physiological Marker. Front. Virtual Real. 2:618855. doi: 10.3389/frvir.2021.618855
Received: 03 December 2020; Accepted: 15 February 2021;
Published: 21 April 2021.
Edited by:Michael Madary, University of the Pacific, United States
Reviewed by:Felix Schoeller, École des Hautes Études en Sciences Sociales, France
Florian Daiber, German Research Center for Artificial Intelligence (DFKI), Germany
Copyright © 2021 Liebherr, Mueller, Schweig, Maas, Schramm and Brand. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
*Correspondence: Magnus Liebherr, email@example.com