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Case Report ARTICLE

Front. Surg., 11 February 2016 | https://doi.org/10.3389/fsurg.2016.00008

Verrucous Carcinoma of the Vulva: A Case Report and Review of the Literature

imageJean Bouquet de Jolinière1*, imageF. Khomsi1, imageJ. M. Gothuey1, imageL. Guillou2, imageA. Fadhlaoui1, imageJ. B. Dubuisson1 and imageA. Feki1
  • 1Department of Gynecologic and Oncologic Surgery, HFR Cantonal Hospital of Fribourg, Fribourg, Switzerland
  • 2Argotlab, Department of Pathology, Lausanne, Switzerland

Verrucous carcinoma of the vulva is a rare lesion (1). Affecting essentially postmenopausal women, this lesion is a distinct and particular entity in vulval carcinoma classification and its scalability is uncertain and unpredictable. Here, we present a case concerning a 48-year-old patient, without follow-up after a condyloma acuminate of the vulva (large left lip). The origin of this case will be discussed in this article. The treatment decided was only surgical. A review of literature shows the rarity of this lesion of the female genital tract.

Introduction

The verrucous carcinoma is an uncommon lesion in the vulvar cancer classification. Effectively, its characterization is defined by a slow growing, no metastasis or lymph node involvement (2), and its appearance is exophitic (3) and impressive. We observe very often a destructive alteration of the tissues. Verrucous carcinoma is a tumor with thickness that can invade and compress the underlying stroma with “pushing margins” (1, 2). The induration resulting from the surrounding tissue and enlargement of regional lymph nodes may mislead the clinician into making an erroneous diagnosis of squamous cell carcinoma (1, 2). A biopsy is absolutely necessary before any decision and treatment.

When the incidence of malignancy is low (1–2% of genital cancers), the treatment is essentially surgical, with a large excision and a strict follow-up.

It is essential to analyze the pathogenesis of this lesion: recently, the role of HPV (human papilloma virus) has been indicated (3, 4). But many others factors can create a “fertile ground” for the development of the lesion: smoking, hormonal deficiency, and diabetes, each of them associated is with an HPV infection, but the majority describes lesions without HPV infection (1, 5).

In literature (1, 6, 7), most surgeons recommend only a local excision as the best treatment without any lymph nodes removal. Other treatments are inefficient (radiotherapy, local chemotherapy, cryotherapy, etc.). In these cases, the recurrence rate is high. Because recurrence may occur if surgical resection margins are involved by the tumor, the pathologist should carefully consider these margins: it is the reason why a large and deep surgery is necessary. It is important to note that the recurrence of verrucous carcinoma announces a bad prognosis (6).

Otherwise, others localizations may be found in the anal channel, vagin (6, 8).The partner must be examined systematically. The epidemiology, pathogenesis, and localization are those of HPV.

Clinical History

This 48-year-old patient consulted 2 years before for a pruritus on the left lip. The vulvoscopy showed a condyloma acuminate; the gynecologist had not performed a biopsy and given a cream with podophyllin.

After the failure of treatment, another gynecologist decided to vaporize the lesion with a CO2 laser, without a previous biopsy. The patient developed in 2 years (without following) a giant tumor (2 cm of diameter minimum).

A first resection by the third gynecologist is performed, with partial removal of the clitoris.

The results confirm a verrucous carcinoma (1.8 × 1.2 × 0.3), the margins are in the tumor (left side and deep section) (dermal invasion of 1.9 mm).

The decision of multidisciplinary meeting is for a partial vulvectomy in our department with a vulvoplasty and a replantation of the clitoris (Figures 1 and 2).

FIGURE 1
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Figure 1. Drawing in blue for surgical incision.

FIGURE 2
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Figure 2. End of surgery.

The final pathology shows total free margins (Figures 3A–H). The anatomical and functional results are good. No complementary treatment was decided. But follow-up was organized. The patient must be seen every 6 months. The PAP is normal and the partner safe.

FIGURE 3
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Figure 3. Pathological pictures.

Discussion

The verrucous carcinoma is a variant of squamous carcinoma (<1% of vulvar cancer).

The main reasons for the patient consulting are itching and pain (vulvodynia).

The pathological report must include histological type, differentiation, and infiltration: measurement of tumor penetration from the dermis papillary to the deep edge of the tumor invasion with minimum margins in millimeter.

Many authors have found HPV genome in the carcinoma tissue (9).

It is always necessary to evaluate the cervix (PAP, colposcopy) because vulva and cervix have a common embryologic origin (squamous tissue) from ectodermic differentiation. In some cases, a cervix dysplasia (CIN) may be found associated with HPV disease and must be treated.

In our case, the pathologic description shows in the vulvectomy: a squamous epithelium, with a mature orthokeratosic and kyperkerathosis surface without koilocytes, with sparse lymphocytic infiltrate. All surgical margins are in healthy tissue.

In Figures 1 and 2, the surgical incision was large. Indeed, the surgery must avoid a potential invasion of deep adjacent structures. A strict follow-up is performed to research any recurrence.

Finally, the prognosis is, anyway, good, depending of an initial extensive surgery.

Ethics Statement

Written informed consent was obtained from the patient prior to presenting the case.

Author Contributions

Jean Bouquet de Jolinière, F. Khomsi, J. M. Gothuey, L. Guillou, A. Fadhlaoui, J. B. Dubuisson and A. Feki: All have participated in this work.

Conflict of Interest Statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

References

1. Boutas I, Sofoudis C, Kalampokas E, Anastasopoulos C, Kalampokas T, Salakos N. Verrucous carcinoma of the vulva: a case report. Case Rep Obstet Gynecol (2013) 2013:932712. doi: 10.1155/2013/932712

PubMed Abstract | CrossRef Full Text | Google Scholar

2. Japaze H, Van Dinh T, Woodruff JD. Verrucous carcinoma of the vulva: study of 24 cases. Obstet Gynecol (1982) 60(4):462–6.

PubMed Abstract | Google Scholar

3. Majewski S, Jablonska S. Human papillomavirus-associated tumors of the skin and mucosa. J Am Acad Dermatol (1997) 36(5I):659–85. doi:10.1016/S0190-9622(97)80315-5

PubMed Abstract | CrossRef Full Text | Google Scholar

4. Crowther ME, Shepherd JH, Fisher C. Verrucous carcinoma of the vulva containing human papilloma virus. 11 cases report. Br J Obstet Gynaecol (1988) 95(4):414–8. doi:10.1111/j.1471-0528.1988.tb06617.x

CrossRef Full Text | Google Scholar

5. Gualco M, Bonin S, Foglia G, Fulcheri E, Odicino F, Prefumo F, et al. Morphologic and biologic studies on ten cases of verrucous carcinoma of the vulva supporting the theory of a discrete clinico-pathologic entity. Int J Gynecol Cancer (2003) 13(3):317–24. doi:10.1046/j.1525-1438.2003.13200.x

PubMed Abstract | CrossRef Full Text | Google Scholar

6. Crowther ME, Lowe DG, Shepherd JH. Verrucous carcinoma of the female genital tract: a review. Obstet Gynecol Surv (1988) 43(5):263–80. doi:10.1097/00006254-198843050-00003

PubMed Abstract | CrossRef Full Text | Google Scholar

7. Gallousis S. Verrucous carcinoma. Report of three vulvar cases and review of the literature. Obstet Gynecol (1972) 40(4):502–7.

Google Scholar

8. Schwartz RA. Verrucous carcinoma of the skin and mucosa. J Am Acad Dermatol (1995) 32(1):1–24. doi:10.1016/0190-9622(95)90177-9

PubMed Abstract | CrossRef Full Text | Google Scholar

9. Hildesheim A, Han CL, Brinton LA, Kurman RJ, Schiller JT. Human papillomavirus type 16 and risk of preinvasive and invasive vulvar cancer: results from a seroepidemiological case-control study. Obstet Gynecol (1997) 90(5):748–54. doi:10.1016/S0029-7844(97)00467-5

PubMed Abstract | CrossRef Full Text | Google Scholar

Keywords: vulva carcinoma, verrucous carcinoma, vulva surgery, HPV, condyloma

Citation: Bouquet de Jolinière J, Khomsi F, Gothuey JM, Guillou L, Fadhlaoui A, Dubuisson JB and Feki A (2016) Verrucous Carcinoma of the Vulva: A Case Report and Review of the Literature. Front. Surg. 3:8. doi: 10.3389/fsurg.2016.00008

Received: 15 October 2015; Accepted: 25 January 2016;
Published: 11 February 2016

Edited by:

Fauziah Binti Jummaat, Hospital Universiti Sains Malaysia, Malaysia

Reviewed by:

Sara Imboden, Inselspital, Switzerland
Salim Alfred Bassil, Al Arz Hospital, Lebanon

Copyright: © 2016 Bouquet de Jolinière, Khomsi, Gothuey, Guillou, Fadhlaoui, Dubuisson and Feki. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

*Correspondence: Jean Bouquet de Jolinière, jean.bouquetdejoliniere@h-fr.ch