Frontiers in Aging Neuroscience

Original Research

Accepted on 19 Jan 2026

Plasma phospho-tau 217 outperforms plasma phospho-tau 181 analyzed with Lumipulse in detecting Alzheimer's dementia in a real-world memory clinic population

in Alzheimer's Disease and Related Dementias

Michaela Defrancesco
Elke R Gizewski
Ruth Steiger
Irene Virgolini
Alexander Stephan Kroiss
Timo Schurr
Jan Paul Görtz
Josef Marksteiner
Alex Hofer
Christian Humpel

Frontiers in Aging Neuroscience

252 views

Original Research

Accepted on 19 Jan 2026

Towards an understanding of real-world mobility in Parkinson's: insights from enhanced contextualisation using GPS-derived location and data-driven modelling of walking speed

in Parkinson’s Disease and Aging-related Movement Disorders

Cameron John Kirk
Rana Zia UR Rehman
Brook Galna
Saverio Ranciati
Emma Packer
Neil Ireson
Vitaveska Lanfranchi
Claudia Mazzà
Lynn Rochester
Alison J. Yarnall

Frontiers in Aging Neuroscience

250 views

Review

Accepted on 19 Jan 2026

Heat Shock Proteins (Hsp70 and Hsp90) in Neurodegeneration: Pathogenic Roles and Therapeutic Potential

in Cellular and Molecular Mechanisms of Brain-aging

Noureddine Ben Khalaf

Frontiers in Aging Neuroscience

274 views

Original Research

Accepted on 16 Jan 2026

Nightly variations in sleep quality and next-day cognitive performance: an in-home study in healthy older adults

in Neurocognitive Aging and Behavior

Mary Brooks
Randa El Chami
Hugo R. Jourde
Marie-Anick Savard
Emily BJ Coffey

Frontiers in Aging Neuroscience

1,015 views

Review

Accepted on 16 Jan 2026

The genetic architecture of Parkinson's disease in Mexico: a systematic review

in Parkinson’s Disease and Aging-related Movement Disorders

Oscar Arias-Carrión
Elizabeth Romero-Gutiérrez
Francisco Xavier Castellanos-Juarez
ADA A. SANDOVAL-CARRILLO
José M. Salas-Pacheco

Frontiers in Aging Neuroscience

268 views

Brief Research Report

Published on 16 Jan 2026

After cochlear implantation in older adults, enhanced working memory does not fully mediate the relationship between CI and improved semantic fluency

in Neurocognitive Aging and Behavior

Maria Huber
Angelika Illg
Lisa Reuter
Lennart Weitgasser

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1701934

624 views

Review

Published on 16 Jan 2026

Research progress on 40 Hz sensory stimulation for the treatment of Alzheimer’s disease

in Alzheimer's Disease and Related Dementias

Bing Tang
Ming Tao

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1710041

2,572 views

Original Research

Published on 16 Jan 2026

Combining plasma biomarkers, clinical parameters, and neuroimaging features for differential diagnosis of Parkinson’s disease and atypical parkinsonian syndromes: a multidimensional modeling approach

in Parkinson’s Disease and Aging-related Movement Disorders

Jian Yao
Jiajia Ma
Peng Li
Xianglian Liao
Jie Zan
Liangshan Hu
Guihua Li

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2026.1727812

666 views

Systematic Review

Published on 16 Jan 2026

The validity of visual and hearing impairment in predicting dementia and cognitive impairment in older adults: a systematic review and meta-analysis

in Alzheimer's Disease and Related Dementias

Qingwen Gan
Yiling Yuan
Qianqian Hu
Yonghui Zhang

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1656686

1,037 views

Original Research

Published on 15 Jan 2026

Early and progressive retinal microglial changes in APPNL-F/NL-F mouse model of Alzheimer’s disease revealed by an automated image analysis software

in Cellular and Molecular Mechanisms of Brain-aging

Lidia Sánchez-Puebla
Inés López-Cuenca
Miguel A. Sánchez-Puebla
Ana Granados
Ana I. Ramírez
Juan Llorens
Takaomi C. Saido
Takashi Saito
Carmen Nieto-Vaquero
María A. Moro

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1712480

1,263 views

Original Research

Published on 15 Jan 2026

Polarity-dependent modulation of sleep oscillations and cortical excitability in aging

in Neurocognitive Aging and Behavior

Buse Dikici
Robert Malinowski
Jan-Bernhard Kordaß
Klaus Obermayer
Julia Ladenbauer
Agnes Flöel

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1704130

698 views

Review

Published on 15 Jan 2026

Effect of deep brain stimulation on dysphagia in Parkinson’s disease: mechanisms, evidence, and outlook

in Parkinson’s Disease and Aging-related Movement Disorders

Jule Hofacker
Bahne H. Bahners
Cinja Huber
Christian J. Hartmann
Inga Claus
Sonja Suntrup-Krueger
Alfons Schnitzler
Tobias Warnecke
Bendix Labeit

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1734432

1,105 views

Original Research

Published on 15 Jan 2026

A cross-database bibliometric analysis of rapid eye movement sleep behavior disorder in Parkinson’s disease research

in Parkinson’s Disease and Aging-related Movement Disorders

Shengjie Du
Xijiang Tian
Rui Ren
Luya Shi

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1744493

1,006 views

Original Research

Accepted on 14 Jan 2026

Prediction of Treatment Responsiveness to Home-based Transcranial Photobiomodulation (tPBM) Intervention for Cognitive Decline Using fNIRS Concurrently Recorded during tPBM

in Alzheimer's Disease and Related Dementias

Minyoung Chun
Kyeonggu Lee
Bori Jung
Yunsu Kim
Chaeyeon Yang
JongKwan Choi
Jihyun Cha
Seung-Hwan Lee
Chang-Hwan Im

Frontiers in Aging Neuroscience

256 views

Original Research

Published on 14 Jan 2026

Electroacupuncture alleviates Parkinson’s disease by targeting HDAC/SIRT-mediated deacetylation of 14-3-3

in Parkinson’s Disease and Aging-related Movement Disorders

Zhao-Qin Wang
Han-Dan Zheng
Ling-Jie Li
Lu-Lu Cao
Lin Shen
Yu Qiao
Yi-Yi Chen
Lu-Yi Wu
Guo-Na Li
Huan-Gan Wu

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1719326

917 views

Original Research

Published on 14 Jan 2026

The differential expression profiles of miRNA in serum-derived exosomes and its potential role in age-related hearing loss

in Neuroinflammation and Neuropathy

Juhong Zhang
Haizhu Ma
Jing Ke
Ziyi Tang
Zhiji Chen
Guijun Yang
Li Yang
Jialin Guo
Xiaoqi Yan
Changxiu Peng

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1694514

812 views

Original Research

Published on 14 Jan 2026

Cardiorespiratory fitness does not predict longitudinal changes in manual dexterity, cognition or corticospinal excitability in multiple sclerosis

in Neurocognitive Aging and Behavior

Basel Mohamed
Sarah Duraid
Nick W. Bray
Arthur R. Chaves
Michelle Ploughman

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1628832

798 views

Original Research

Accepted on 13 Jan 2026

Research on Alzheimer's Disease MRI Image Classification Based on Spatial Attention Mechanism

in Alzheimer's Disease and Related Dementias

Shanshan Zhao
Haolin Shi
Yanli Wan
Changhao Guan
Qingjia Zeng
Chongyang Zhang

Frontiers in Aging Neuroscience

171 views

Original Research

Published on 13 Jan 2026

Influence of anesthetic agent and burst suppression on postoperative delirium in elderly patients: a prospective cohort study with automated EEG analysis

in Neurocognitive Aging and Behavior

Maximilian Markus
Marc Dorenbeck
Vera Röhr
Sophie Leroy
Benjamin Blankertz
Emery N. Brown
Claudia Spies
Susanne Koch

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1743267

1,379 views

Original Research

Published on 13 Jan 2026

Correlation between blood biomarkers and post-stroke cognitive impairment

in Neurocognitive Aging and Behavior

Xianjun Liu
Zhaoyang Lv
Zhihong Shi
Feng Liu
Hao Wu
Shuai Liu
Yong Ji

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1736338

810 views

Original Research

Published on 13 Jan 2026

The aggregate proteome of Caenorhabditis elegans mitochondria implicates shared mechanisms of aging and Alzheimer’s disease

in Cellular and Molecular Mechanisms of Brain-aging

Sonu Pahal
Akshatha Ganne
Meenakshisundaram Balasubramaniam
Sue T. Griffin
Robert J. Shmookler Reis
Srinivas Ayyadevara

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1713391

1,185 views

Original Research

Published on 13 Jan 2026

Machine learning-guided analysis of metabolomic alterations in Parkinson’s disease with comorbid symptoms

in Parkinson’s Disease and Aging-related Movement Disorders

Ran Sun
Lin Wang
Yanli Wang
Jinghui Feng
Xingrao Wu
Jinbiao Li
Meng Wang
Wenxuan Chen
Hongping Lai
Hao Wang

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1753016

730 views

Original Research

Published on 13 Jan 2026

Research trends and frontiers of astrocytes in cognitive impairment: a bibliometric analysis from 2015 to 2024

in Neuroinflammation and Neuropathy

Zhilin Huang
Wanting Liu
Yating Zhang
BiXiang Zha
Ping Wang
Jun Yang

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1708008

1,158 views

Original Research

Published on 13 Jan 2026

The olfactory functional network in the Alzheimer’s disease continuum: a resting state fMRI study

in Alzheimer's Disease and Related Dementias

Daniela Ballotta
Claudia Casadio
Manuela Tondelli
Vanessa Zanelli
Francesco Ricci
Omar Carpentiero
Fausta Lui
Nicola Filippini
Annalisa Chiari
Maria Angela Molinari

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1744413

725 views

7,794 articles

articles

Plasma phospho-tau 217 outperforms plasma phospho-tau 181 analyzed with Lumipulse in detecting Alzheimer's dementia in a real-world memory clinic population

Towards an understanding of real-world mobility in Parkinson's: insights from enhanced contextualisation using GPS-derived location and data-driven modelling of walking speed

Heat Shock Proteins (Hsp70 and Hsp90) in Neurodegeneration: Pathogenic Roles and Therapeutic Potential

Nightly variations in sleep quality and next-day cognitive performance: an in-home study in healthy older adults

The genetic architecture of Parkinson's disease in Mexico: a systematic review

After cochlear implantation in older adults, enhanced working memory does not fully mediate the relationship between CI and improved semantic fluency

Research progress on 40 Hz sensory stimulation for the treatment of Alzheimer’s disease

Combining plasma biomarkers, clinical parameters, and neuroimaging features for differential diagnosis of Parkinson’s disease and atypical parkinsonian syndromes: a multidimensional modeling approach

The validity of visual and hearing impairment in predicting dementia and cognitive impairment in older adults: a systematic review and meta-analysis

Early and progressive retinal microglial changes in APPNL-F/NL-F mouse model of Alzheimer’s disease revealed by an automated image analysis software

Polarity-dependent modulation of sleep oscillations and cortical excitability in aging

Effect of deep brain stimulation on dysphagia in Parkinson’s disease: mechanisms, evidence, and outlook

A cross-database bibliometric analysis of rapid eye movement sleep behavior disorder in Parkinson’s disease research

Prediction of Treatment Responsiveness to Home-based Transcranial Photobiomodulation (tPBM) Intervention for Cognitive Decline Using fNIRS Concurrently Recorded during tPBM

Electroacupuncture alleviates Parkinson’s disease by targeting HDAC/SIRT-mediated deacetylation of 14-3-3

The differential expression profiles of miRNA in serum-derived exosomes and its potential role in age-related hearing loss

Cardiorespiratory fitness does not predict longitudinal changes in manual dexterity, cognition or corticospinal excitability in multiple sclerosis

Research on Alzheimer's Disease MRI Image Classification Based on Spatial Attention Mechanism

Influence of anesthetic agent and burst suppression on postoperative delirium in elderly patients: a prospective cohort study with automated EEG analysis

Correlation between blood biomarkers and post-stroke cognitive impairment

The aggregate proteome of Caenorhabditis elegans mitochondria implicates shared mechanisms of aging and Alzheimer’s disease

Machine learning-guided analysis of metabolomic alterations in Parkinson’s disease with comorbid symptoms

Research trends and frontiers of astrocytes in cognitive impairment: a bibliometric analysis from 2015 to 2024

The olfactory functional network in the Alzheimer’s disease continuum: a resting state fMRI study

articles

Plasma phospho-tau 217 outperforms plasma phospho-tau 181 analyzed with Lumipulse in detecting Alzheimer's dementia in a real-world memory clinic population

Towards an understanding of real-world mobility in Parkinson's: insights from enhanced contextualisation using GPS-derived location and data-driven modelling of walking speed

Heat Shock Proteins (Hsp70 and Hsp90) in Neurodegeneration: Pathogenic Roles and Therapeutic Potential

Nightly variations in sleep quality and next-day cognitive performance: an in-home study in healthy older adults

The genetic architecture of Parkinson's disease in Mexico: a systematic review

After cochlear implantation in older adults, enhanced working memory does not fully mediate the relationship between CI and improved semantic fluency

Research progress on 40 Hz sensory stimulation for the treatment of Alzheimer’s disease

Combining plasma biomarkers, clinical parameters, and neuroimaging features for differential diagnosis of Parkinson’s disease and atypical parkinsonian syndromes: a multidimensional modeling approach

The validity of visual and hearing impairment in predicting dementia and cognitive impairment in older adults: a systematic review and meta-analysis

Early and progressive retinal microglial changes in APPNL-F/NL-F mouse model of Alzheimer’s disease revealed by an automated image analysis software

Polarity-dependent modulation of sleep oscillations and cortical excitability in aging

Effect of deep brain stimulation on dysphagia in Parkinson’s disease: mechanisms, evidence, and outlook

A cross-database bibliometric analysis of rapid eye movement sleep behavior disorder in Parkinson’s disease research

Prediction of Treatment Responsiveness to Home-based Transcranial Photobiomodulation (tPBM) Intervention for Cognitive Decline Using fNIRS Concurrently Recorded during tPBM

Electroacupuncture alleviates Parkinson’s disease by targeting HDAC/SIRT-mediated deacetylation of 14-3-3

The differential expression profiles of miRNA in serum-derived exosomes and its potential role in age-related hearing loss

Cardiorespiratory fitness does not predict longitudinal changes in manual dexterity, cognition or corticospinal excitability in multiple sclerosis

Research on Alzheimer's Disease MRI Image Classification Based on Spatial Attention Mechanism

Influence of anesthetic agent and burst suppression on postoperative delirium in elderly patients: a prospective cohort study with automated EEG analysis

Correlation between blood biomarkers and post-stroke cognitive impairment

The aggregate proteome of Caenorhabditis elegans mitochondria implicates shared mechanisms of aging and Alzheimer’s disease

Machine learning-guided analysis of metabolomic alterations in Parkinson’s disease with comorbid symptoms

Research trends and frontiers of astrocytes in cognitive impairment: a bibliometric analysis from 2015 to 2024

The olfactory functional network in the Alzheimer’s disease continuum: a resting state fMRI study

Research progress on 40 Hz sensory stimulation for the treatment of Alzheimer’s disease