Frontiers in Aging Neuroscience | Cellular and Molecular Mechanisms of Brain-aging

Review

Published on 20 Aug 2025

Pathophysiological insights and therapeutic developments in age-related hearing loss: a narrative review

in Cellular and Molecular Mechanisms of Brain-aging

Shichu Sun
Qi Zhao
Haojia He
Yujia Liu
Yuchong Nie
You Zhou

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1657603

968 views

Brief Research Report

Published on 19 Aug 2025

Modulation of fenestrated vasculature in the median eminence and area postrema in response to neurotoxin exposure and its impairment in aging

in Cellular and Molecular Mechanisms of Brain-aging

Viana Q. Pham
Melike Tutunculer
Halah Al-Dulaimi
Daniel Ardjmand
William Fleischmann
Tomas P. Bachor
Allison W. Xu

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1634283

914 views

Systematic Review

Published on 18 Aug 2025

Glutamate-associated research in Parkinson’s disease: a bibliometric analysis

in Cellular and Molecular Mechanisms of Brain-aging

Yan-Jun Chen
Ming-Rong Xie
Sheng-Qiang Zhou
Fang Liu

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1569924

594 views

Original Research

Published on 13 Aug 2025

Gut dysbiosis is associated with increased blood–brain barrier permeability and cognitive impairment in elderlies with coronary heart disease

in Cellular and Molecular Mechanisms of Brain-aging

Lichao Di
Peiying Huang
Yeju He
Na Sun
Liwei Chi
Lining Huang

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1640761

596 views

Review

Published on 07 Aug 2025

Curcumin and neuroplasticity: epigenetic mechanisms underlying cognitive enhancement in aging and neurodegenerative disorders

in Cellular and Molecular Mechanisms of Brain-aging

Hao Jiao
Xiuying Wang
Dahui Zhang
Shengxue Zhou
Feng Gao

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1592280

1,258 views

Correction

Published on 05 Aug 2025

Correction: Optineurin overexpression ameliorates neurodegeneration through regulating neuroinflammation and mitochondrial quality in a murine model of amyotrophic lateral sclerosis

in Cellular and Molecular Mechanisms of Brain-aging

Shumin Zhao
Ranran Chen
Yi An
Yali Zhang
Cheng Ma
Ying Gao
Yanchao Lu
Fei Yang
Xue Bai
Jingjing Zhang

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1670545

494 views

Review

Published on 29 Jul 2025

The interplay between physical exercise and autophagy signaling in brain health, neurodegenerative diseases and aging

in Cellular and Molecular Mechanisms of Brain-aging

Bo Gao
Li Wang
Jian Gong
Zehua Zhu
Qi Liu
Han Yuan
Haitao Wang

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1579208

1,626 views

Brief Research Report

Published on 25 Jul 2025

Molecular targets of neuroplasticity in ischemic stroke: insights from GEO database, single-cell analysis and immune infiltration analysis

in Cellular and Molecular Mechanisms of Brain-aging

Haoyue Yang
Zekun Li
Lu Zhang
Haifeng Zhang
Yang Liu
Wei Chen
Feng Zhang

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1561282

2,012 views

Review

Published on 24 Jul 2025

NMDA receptors in neurodegenerative diseases: mechanisms and emerging therapeutic strategies

in Cellular and Molecular Mechanisms of Brain-aging

Keyi Zhang
Ming Wen
Xinyue Nan
Shuaizhu Zhao
Hao Li
Yanping Ai
Houze Zhu

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1604378

1,961 views

Original Research

Published on 23 Jul 2025

Ambroxol confers neuroprotection against scopolamine-induced Alzheimer’s-like pathology by modulating oxidative stress, neuroinflammation, and cognitive deficits via Nrf-2/JNK/GSK-3β signaling pathways

in Cellular and Molecular Mechanisms of Brain-aging

Waqas Ahmad
Kyonghwan Choe
Riaz Ahmad
Tae Ju Park
Myeong Ok Kim

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1607289

1,751 views

Original Research

Published on 23 Jul 2025

Neuropeptide Y mRNA expression in the aging inferior colliculus of fischer brown norway rats

in Cellular and Molecular Mechanisms of Brain-aging

Laila S. Almassri
Kristen M. Crane
Sean R. Hergenrother
Gurveer Singh
Gillian L. Barach
Melina C. Iafrate
Joshua C. Harris
Nick Tokar
Andrew P. Ohl
Jesse W. Young

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1626021

1,126 views

Original Research

Published on 23 Jul 2025

Vulnerability of long-range inputome of basal forebrain in normal aging mice

in Cellular and Molecular Mechanisms of Brain-aging

Tingting Sun
Jiale Chen
Bimin Liu
Anan Li
Hui Gong
Xiangning Li

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1573906

1,048 views

Mini Review

Published on 22 Jul 2025

Sex differences in the outcomes of modifiable lifestyle factors for cognitive aging: neuroinflammation and microglia as key underlying mechanisms

in Cellular and Molecular Mechanisms of Brain-aging

Samantha G. Coleborn
Zoë M. Gilson
Yunyong Guo
Marie-Ève Tremblay

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1642043

1,404 views

Review

Published on 21 May 2025

Exercise training exerts beneficial effects on Alzheimer’s disease through multiple signaling pathways

in Cellular and Molecular Mechanisms of Brain-aging

Jihe Kang
Mei Liu
Qiang Yang
Xiangji Dang
Qun Li
Ting Wang
Bin Qiu
Yibao Zhang
Xudong Guo
Xiaoling Li

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1558078

3,012 views
1 citation

Original Research

Published on 09 May 2025

Subregional analysis of the amygdala, thalamus, and hypothalamus at the pre-decline stage in Parkinson’s disease with later cognitive impairment

in Cellular and Molecular Mechanisms of Brain-aging

Kazuhide Seo
Genko Oyama
Toshimasa Yamamoto

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1588027

1,671 views

Original Research

Published on 30 Apr 2025

Amyloid-beta peptide toxicity in the aged brain is a one-way journey into Alzheimer’s disease

in Cellular and Molecular Mechanisms of Brain-aging

Georgia Culley
Alexandre Henriques
Delphine Hardy
Alexandre Wojcinski
Adrien Chabert
Bilal El Waly
Philippe Poindron
Noelle Callizot

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1569181

2,934 views