Frontiers in Aging Neuroscience | Cellular and Molecular Mechanisms of Brain-aging

Review

Published on 03 Sep 2026

Ferroptosis–neuroinflammation interplay: mechanistic pathways and therapeutic opportunities in central nervous system disorders

in Cellular and Molecular Mechanisms of Brain-aging

Khuzin Dinislam
Valeriy A. Kataev
Mohammad Rehan Ajmal
Ayman S. Amer
Pratibha Prasad
Azna Zuberi

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2026.1874307

463 views

Review

Published on 01 Sep 2026

Advances in the treatment of age-related hearing loss: from molecular mechanisms to targeted interventions

in Cellular and Molecular Mechanisms of Brain-aging

Le Mao
Sijie Ma
Kun Zhu
Chao Feng
Xinyu Chen
Fangli Yang
Maoli Duan
Xiaowan Chen

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2026.1924937

308 views

Original Research

Published on 31 Aug 2026

Short-term environmental enrichment modulates brain region-specific redox responses in adolescent female mice

in Cellular and Molecular Mechanisms of Brain-aging

Matheus Santos de Sousa Fernandes
Alexandre Kanashiro
Tiago Lacerda Ramos
Danielle Dutra Pereira
Vanessa Lima de Souza
Claudia Jaques Lagranha
Sacide Tüfekci
Burak Yagin
Nouf H. Alkhamees
Fabrício Oliveira Souto

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2026.1889960

373 views

Original Research

Accepted on 30 Aug 2026

Association Between Minimum Nocturnal Heart Rate and Cerebral Small Vessel Disease in Patients with Obstructive Sleep Apnea

in Cellular and Molecular Mechanisms of Brain-aging

Yian Lu
yining wen
Fangmei Chen
Ankang Liang
Qingqing Zhong
Wenqiu Wei
Xiaoyi Shi
Manchan Wei
Mingming Zhao

Frontiers in Aging Neuroscience

148 views

Original Research

Accepted on 28 Aug 2026

Chronic nicotine reverses age-related decline of interneuron markers in mouse auditory cortex

in Cellular and Molecular Mechanisms of Brain-aging

Irakli Intskirveli
Ronit Lazar
Dianna Hidalgo
Raju Metherate

Frontiers in Aging Neuroscience

223 views

Original Research

Published on 28 Aug 2026

Astragaloside IV attenuates hypoxia-reoxygenation-induced endothelial senescence and vascular inflammation by modulating the NOTCH1/VCAM-1 axis

in Cellular and Molecular Mechanisms of Brain-aging

Dehui Huang
Rongjing Zhou
Jun Ling

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2026.1855522

638 views

Editorial

Accepted on 20 Aug 2026

Editorial: Stem Cell Niche in Brain Aging and Neurodegenerative Disorders

in Cellular and Molecular Mechanisms of Brain-aging

Shouneng Peng
Vanessa Castelli
Gangcai Xie
Lilach Soreq

Frontiers in Aging Neuroscience

188 views

Editorial

Published on 18 Aug 2026

Editorial: Bioactive compounds in neuroprotection: unveiling modern therapeutics in aging

in Cellular and Molecular Mechanisms of Brain-aging

Chandra Prakash
Pavan Kumar
Deepak Sharma

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2026.1956060

528 views

Review

Published on 17 Aug 2026

P2X7 receptor-dependent microglia-astrocyte coupling in Alzheimer's disease: from eATP sensing to synaptic and proteostatic failure

in Cellular and Molecular Mechanisms of Brain-aging

Yiwen Li
Shiming Liu
Jiao Lan

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2026.1915244

645 views

Review

Published on 14 Aug 2026

Exercise alone or combined with functional foods in aging and age-related diseases: targeting DNA damage, repair pathways, and genome integrity

in Cellular and Molecular Mechanisms of Brain-aging

Ying Ma
Xuejun Li
He Chen
Rongchang Fan

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2026.1772217

1,032 views

Review

Published on 13 Aug 2026

Potential effects of β-hydroxy-β-methylbutyrate and exercise on brain aging and age-related disorders: implications for immunometabolic regulation and muscle–brain–immune crosstalk

in Cellular and Molecular Mechanisms of Brain-aging

Boyuan Shi
Zheng Han

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2026.1878831

1,127 views

Original Research

Published on 06 Aug 2026

Region-specific brain metabolite reference estimates and exploratory age-related changes in cognitively intact older adults: a preliminary deep-learning 1H-MRS study

in Cellular and Molecular Mechanisms of Brain-aging

Young-Ah Choi
Hyeong Hun Lee
Dong-Kyu Jang
Junghyeon Park
Si Won Yang
Min-Wook Kim

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2026.1896159

762 views

Brief Research Report

Published on 03 Aug 2026

Stereological sampling-based estimates of dopaminergic and cholinergic neuron numbers in young adult and aged male and female Fischer 344 × Brown Norway F1 hybrid rats

in Cellular and Molecular Mechanisms of Brain-aging

Hannah E. Phelps
Merritt R. Reese
Swetha Jeyagopal
Aryan Sahota
Wonn S. Pyon
Jennifer L. Bizon
Barry Setlow
Matthew R. Burns

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2026.1730515

1,646 views

Review

Published on 03 Aug 2026

DNA hydroxymethylation-mediated epigenetic modifications in alcohol use disorder

in Cellular and Molecular Mechanisms of Brain-aging

Sampath Raghul Kannan
Krishna Santhoshkumar
Ramasamy Tamizhselvi

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2026.1858336

1,134 views

Hypothesis and Theory

Published on 03 Aug 2026

A locus coeruleus-centric framework for novelty, salience, and gamma oscillations: implications for neurostimulation, aging, and disease

in Cellular and Molecular Mechanisms of Brain-aging

Brennan L. Jackson

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2026.1895931

1,749 views

Review

Published on 31 Jul 2026

Corticotropin-releasing factor (CRF) in brain aging: from mitochondrial dysfunction to inflammaging

in Cellular and Molecular Mechanisms of Brain-aging

Mengting Yan
Linrui Hua
Jufu Jiang
Jingyi Wu
Ziyan Zeng
Yun He
Yuncai Chen

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2026.1880569

1,100 views

Original Research

Accepted on 27 Jul 2026

Transcriptomic Analysis Identifies Candidate Molecular Mechanisms Underlying SCF+G-CSF-Reduced Neuropathology in Aged APP/PS1 Mice

in Cellular and Molecular Mechanisms of Brain-aging

Afua Addo
Bin Li
Sasidhar Murikinati
Robert Gardner
Li-Ru ZHAO

Frontiers in Aging Neuroscience

366 views

Review

Published on 27 Jul 2026

The prognostic potential of circulating BDNF levels and its polymorphisms in age-related cognitive impairment and neurodegeneration

in Cellular and Molecular Mechanisms of Brain-aging

Tatiana V. Tulupova
Maria V. Vedunova
Elena V. Mitroshina

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2026.1901527

1,217 views

Review

Published on 24 Jul 2026

AI-enabled multimodal neuroimaging for neurotransmitter mapping in normal aging and age-related disease

in Cellular and Molecular Mechanisms of Brain-aging

Paige Hewitt
Hongsheen Kim
Thomas A. Vida

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2026.1748671

1,436 views

Original Research

Published on 14 Jul 2026

Multivariate associations between systemic inflammation, metabolic dysregulation, and cognitive performance in project FRONTIER

in Cellular and Molecular Mechanisms of Brain-aging

Chathurika S. Dhanasekara
Chanaka N. Kahathuduwa
Volker Neugebauer

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2026.1836968

862 views

Review

Published on 13 Jul 2026

Inflammaging and neurovascular unit dysfunction in cognitive ageing: mechanisms, biomarkers, and therapeutic opportunities

in Cellular and Molecular Mechanisms of Brain-aging

Fan Bu
Shulin Zeng
Zhengchi Lou
Sijia Zhou
Xiufen Yang
Yi Wen
Weixiang Luo
Lan Qin

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2026.1841958

1,203 views

Brief Research Report

Published on 03 Jul 2026

Novel proteomics and neuropathology of NOTCH2NLC-related neuronal intranuclear inclusion disease

in Cellular and Molecular Mechanisms of Brain-aging

Feixia Zhan
Jiaxin Zhu
Yang Wang
Yuwen Cao
Xiya Shen
Wenlu Lv
Jiewei Wei
Xiaojun Huang
Steven X. Hou
Xinghua Luan

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2026.1827292

1,144 views

Brief Research Report

Published on 30 Jun 2026

Age-associated microglial heterogeneity includes emergence of mobile microglial states

in Cellular and Molecular Mechanisms of Brain-aging

Sunitha Subhramanian
Olga Bocharova
Olga Mychko
Natallia Makarava
Ilia V. Baskakov

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2026.1847223

1,405 views

Review

Published on 24 Jun 2026

ZBTB7A-mediated regulation of astrocytic glycolysis in neurodegenerative diseases: insights from literature review and bioinformatics prediction

in Cellular and Molecular Mechanisms of Brain-aging

Ping Ye
Zhen Li
Xingang Cui
Hong Wu
Hong Jiang

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2026.1852019

1,119 views

809 articles

articles

Ferroptosis–neuroinflammation interplay: mechanistic pathways and therapeutic opportunities in central nervous system disorders

Advances in the treatment of age-related hearing loss: from molecular mechanisms to targeted interventions

Short-term environmental enrichment modulates brain region-specific redox responses in adolescent female mice

Association Between Minimum Nocturnal Heart Rate and Cerebral Small Vessel Disease in Patients with Obstructive Sleep Apnea

Chronic nicotine reverses age-related decline of interneuron markers in mouse auditory cortex

Astragaloside IV attenuates hypoxia-reoxygenation-induced endothelial senescence and vascular inflammation by modulating the NOTCH1/VCAM-1 axis

Editorial: Stem Cell Niche in Brain Aging and Neurodegenerative Disorders

Editorial: Bioactive compounds in neuroprotection: unveiling modern therapeutics in aging

P2X7 receptor-dependent microglia-astrocyte coupling in Alzheimer's disease: from eATP sensing to synaptic and proteostatic failure

Exercise alone or combined with functional foods in aging and age-related diseases: targeting DNA damage, repair pathways, and genome integrity

Potential effects of β-hydroxy-β-methylbutyrate and exercise on brain aging and age-related disorders: implications for immunometabolic regulation and muscle–brain–immune crosstalk

Region-specific brain metabolite reference estimates and exploratory age-related changes in cognitively intact older adults: a preliminary deep-learning 1H-MRS study

Stereological sampling-based estimates of dopaminergic and cholinergic neuron numbers in young adult and aged male and female Fischer 344 × Brown Norway F1 hybrid rats

DNA hydroxymethylation-mediated epigenetic modifications in alcohol use disorder

A locus coeruleus-centric framework for novelty, salience, and gamma oscillations: implications for neurostimulation, aging, and disease

Corticotropin-releasing factor (CRF) in brain aging: from mitochondrial dysfunction to inflammaging

Transcriptomic Analysis Identifies Candidate Molecular Mechanisms Underlying SCF+G-CSF-Reduced Neuropathology in Aged APP/PS1 Mice

The prognostic potential of circulating BDNF levels and its polymorphisms in age-related cognitive impairment and neurodegeneration

AI-enabled multimodal neuroimaging for neurotransmitter mapping in normal aging and age-related disease

Multivariate associations between systemic inflammation, metabolic dysregulation, and cognitive performance in project FRONTIER

Inflammaging and neurovascular unit dysfunction in cognitive ageing: mechanisms, biomarkers, and therapeutic opportunities

Novel proteomics and neuropathology of NOTCH2NLC-related neuronal intranuclear inclusion disease

Age-associated microglial heterogeneity includes emergence of mobile microglial states

ZBTB7A-mediated regulation of astrocytic glycolysis in neurodegenerative diseases: insights from literature review and bioinformatics prediction