Frontiers in Aging Neuroscience | Cellular and Molecular Mechanisms of Brain-aging

Original Research

Published on 10 Oct 2025

Asrij/OCIAD1 contributes to age-associated microglial activation and neuroinflammation in mice

in Cellular and Molecular Mechanisms of Brain-aging

Prathamesh Dongre
Madhu Ramesh
Thimmaiah Govindaraju
Maneesha S. Inamdar

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1674136

749 views

Review

Accepted on 29 Sep 2025

Copper homeostasis and cuproptosis: implications for neurodegenerative diseases

in Cellular and Molecular Mechanisms of Brain-aging

Feng Tao
Mengxuan Lin
Xiang Meng
Linghui Huang
Bifang Zhuo
Siyi Jiang
Jiangwei Shi
Shizhe Deng
Zhihong Meng

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1688554

295 views

Review

Published on 25 Sep 2025

Current aspects of targeting cellular senescence for the therapy of neurodegenerative diseases

in Cellular and Molecular Mechanisms of Brain-aging

Ravindran Jaganathan
Ashok Iyaswamy
Senthilkumar Krishnamoorthi
Abhimanyu Thakur
Siva Sundara Kumar Durairajan
Chuanbin Yang
Dapkupar Wankhar

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1627921

1,743 views

Review

Published on 19 Sep 2025

STING-mediated neuroinflammation: a therapeutic target in neurodegenerative diseases

in Cellular and Molecular Mechanisms of Brain-aging

Haoqin Zhang
Ziyang He
Can Yin
Shiyi Yang
Jianqiao Li
Hong Lin
Guishan Hu
Anguo Wu
Dalian Qin
Guangqiang Hu

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1659216

2,874 views

Review

Published on 20 Aug 2025

Pathophysiological insights and therapeutic developments in age-related hearing loss: a narrative review

in Cellular and Molecular Mechanisms of Brain-aging

Shichu Sun
Qi Zhao
Haojia He
Yujia Liu
Yuchong Nie
You Zhou

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1657603

2,773 views

Brief Research Report

Published on 19 Aug 2025

Modulation of fenestrated vasculature in the median eminence and area postrema in response to neurotoxin exposure and its impairment in aging

in Cellular and Molecular Mechanisms of Brain-aging

Viana Q. Pham
Melike Tutunculer
Halah Al-Dulaimi
Daniel Ardjmand
William Fleischmann
Tomas P. Bachor
Allison W. Xu

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1634283

2,087 views

Systematic Review

Published on 18 Aug 2025

Glutamate-associated research in Parkinson’s disease: a bibliometric analysis

in Cellular and Molecular Mechanisms of Brain-aging

Yan-Jun Chen
Ming-Rong Xie
Sheng-Qiang Zhou
Fang Liu

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1569924

1,696 views

Original Research

Published on 13 Aug 2025

Gut dysbiosis is associated with increased blood–brain barrier permeability and cognitive impairment in elderlies with coronary heart disease

in Cellular and Molecular Mechanisms of Brain-aging

Lichao Di
Peiying Huang
Yeju He
Na Sun
Liwei Chi
Lining Huang

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1640761

1,341 views

Review

Published on 07 Aug 2025

Curcumin and neuroplasticity: epigenetic mechanisms underlying cognitive enhancement in aging and neurodegenerative disorders

in Cellular and Molecular Mechanisms of Brain-aging

Hao Jiao
Xiuying Wang
Dahui Zhang
Shengxue Zhou
Feng Gao

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1592280

3,177 views

Correction

Published on 05 Aug 2025

Correction: Optineurin overexpression ameliorates neurodegeneration through regulating neuroinflammation and mitochondrial quality in a murine model of amyotrophic lateral sclerosis

in Cellular and Molecular Mechanisms of Brain-aging

Shumin Zhao
Ranran Chen
Yi An
Yali Zhang
Cheng Ma
Ying Gao
Yanchao Lu
Fei Yang
Xue Bai
Jingjing Zhang

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1670545

880 views

Review

Published on 29 Jul 2025

The interplay between physical exercise and autophagy signaling in brain health, neurodegenerative diseases and aging

in Cellular and Molecular Mechanisms of Brain-aging

Bo Gao
Li Wang
Jian Gong
Zehua Zhu
Qi Liu
Han Yuan
Haitao Wang

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1579208

3,425 views

Brief Research Report

Published on 25 Jul 2025

Molecular targets of neuroplasticity in ischemic stroke: insights from GEO database, single-cell analysis and immune infiltration analysis

in Cellular and Molecular Mechanisms of Brain-aging

Haoyue Yang
Zekun Li
Lu Zhang
Haifeng Zhang
Yang Liu
Wei Chen
Feng Zhang

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1561282

3,284 views

Review

Published on 24 Jul 2025

NMDA receptors in neurodegenerative diseases: mechanisms and emerging therapeutic strategies

in Cellular and Molecular Mechanisms of Brain-aging

Keyi Zhang
Ming Wen
Xinyue Nan
Shuaizhu Zhao
Hao Li
Yanping Ai
Houze Zhu

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1604378

3,221 views

Original Research

Published on 23 Jul 2025

Ambroxol confers neuroprotection against scopolamine-induced Alzheimer’s-like pathology by modulating oxidative stress, neuroinflammation, and cognitive deficits via Nrf-2/JNK/GSK-3β signaling pathways

in Cellular and Molecular Mechanisms of Brain-aging

Waqas Ahmad
Kyonghwan Choe
Riaz Ahmad
Tae Ju Park
Myeong Ok Kim

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1607289

2,768 views
1 citation

Original Research

Published on 23 Jul 2025

Neuropeptide Y mRNA expression in the aging inferior colliculus of fischer brown norway rats

in Cellular and Molecular Mechanisms of Brain-aging

Laila S. Almassri
Kristen M. Crane
Sean R. Hergenrother
Gurveer Singh
Gillian L. Barach
Melina C. Iafrate
Joshua C. Harris
Nick Tokar
Andrew P. Ohl
Jesse W. Young

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1626021

1,564 views

Original Research

Published on 23 Jul 2025

Vulnerability of long-range inputome of basal forebrain in normal aging mice

in Cellular and Molecular Mechanisms of Brain-aging

Tingting Sun
Jiale Chen
Bimin Liu
Anan Li
Hui Gong
Xiangning Li

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1573906

1,372 views