Frontiers in Aging Neuroscience | Cellular and Molecular Mechanisms of Brain-aging

Original Research

Published on 19 Nov 2019

Inhibition of AMD-Like Pathology With a Neurotrophic Compound in Aged Rats and 3xTg-AD Mice

in Cellular and Molecular Mechanisms of Brain-aging

Yinghua Liu
Wei Wei
Narjes Baazaoui
Fei Liu
Khalid Iqbal

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2019.00309

6,350 views
12 citations

Review

Published on 12 Nov 2019

SIRT3 Regulation of Mitochondrial Quality Control in Neurodegenerative Diseases

in Cellular and Molecular Mechanisms of Brain-aging

Hao Meng
Wan-Yu Yan
Yu-Hong Lei
Zheng Wan
Ye-Ye Hou
Lian-Kun Sun
Jue-Pu Zhou

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2019.00313

15,762 views
101 citations

Original Research

Published on 23 Oct 2019

Proteome Profiling of Cerebral Vessels in Rhesus Macaques: Dysregulation of Antioxidant Activity and Extracellular Matrix Proteins Contributes to Cerebrovascular Aging in Rhesus Macaques

in Cellular and Molecular Mechanisms of Brain-aging

Xia Wang
Yifan Liu
Yangjie Jia
Haotian Liu
Xinjie Bao
Zhanlong He
Wei Ge

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2019.00293

4,469 views
10 citations

Original Research

Published on 24 Sep 2019

Attenuating Cholinergic Transmission Increases the Number of Satellite Cells and Preserves Muscle Mass in Old Age

in Cellular and Molecular Mechanisms of Brain-aging

Sydney K. Vaughan
Natalia M. Sutherland
Gregorio Valdez

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2019.00262

6,764 views
13 citations

Original Research

Published on 13 Sep 2019

Age and Ketogenic Diet Have Dissociable Effects on Synapse-Related Gene Expression Between Hippocampal Subregions

in Cellular and Molecular Mechanisms of Brain-aging

Abbi R. Hernandez
Caesar M. Hernandez
Leah M. Truckenbrod
Keila T. Campos
Joseph A. McQuail
Jennifer L. Bizon
Sara N. Burke

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2019.00239

8,594 views
29 citations

Original Research

Published on 12 Sep 2019

In vivo Bioluminescence Imaging Used to Monitor Disease Activity and Therapeutic Response in a Mouse Model of Tauopathy

in Cellular and Molecular Mechanisms of Brain-aging

Ambrose A. Dunn-Meynell
Peter Dowling
Michelle Marchese
Esther Rodriguez
Benjamin Blumberg
Yun-Beom Choi
Deeya Gaindh
Wei Lu

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2019.00252

5,631 views
10 citations

Original Research

Published on 12 Sep 2019

A Pilot Study Investigating Changes in the Human Plasma and Urine NAD+ Metabolome During a 6 Hour Intravenous Infusion of NAD+

in Cellular and Molecular Mechanisms of Brain-aging

Ross Grant
Jade Berg
Richard Mestayer
Nady Braidy
James Bennett
Susan Broom
James Watson

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2019.00257

74,266 views
39 citations

Brief Research Report

Published on 04 Sep 2019

Memory Decline and Behavioral Inflexibility in Aged Mice Are Correlated With Dysregulation of Protein Synthesis Capacity

in Cellular and Molecular Mechanisms of Brain-aging

Wenzhong Yang
Xueyan Zhou
Tao Ma

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2019.00246

9,691 views
42 citations

Original Research

Published on 04 Sep 2019

Appoptosin Mediates Lesions Induced by Oxidative Stress Through the JNK-FoxO1 Pathway

in Cellular and Molecular Mechanisms of Brain-aging

Cuilin Zhang
Zhenqiu Tan
Yongzhuang Xie
Yingjun Zhao
Timothy Y. Huang
Zhaoping Lu
Hong Luo
Dan Can
Huaxi Xu
Yun-wu Zhang

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2019.00243

5,060 views
11 citations

Brief Research Report

Published on 30 Aug 2019

Novel Functions of the Neurodegenerative-Related Gene Tau in Cancer

in Cellular and Molecular Mechanisms of Brain-aging

Ricardo Gargini
Berta Segura-Collar
Pilar Sánchez-Gómez

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2019.00231

9,361 views
60 citations

Review

Published on 28 Aug 2019

Exosome Determinants of Physiological Aging and Age-Related Neurodegenerative Diseases

in Cellular and Molecular Mechanisms of Brain-aging

Marianna D’Anca
Chiara Fenoglio
Maria Serpente
Beatrice Arosio
Matteo Cesari
Elio Angelo Scarpini
Daniela Galimberti

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2019.00232

23,119 views
150 citations

Original Research

Published on 27 Aug 2019

Synergistic Effects of Curcumin and Piperine as Potent Acetylcholine and Amyloidogenic Inhibitors With Significant Neuroprotective Activity in SH-SY5Y Cells via Computational Molecular Modeling and in vitro Assay

in Cellular and Molecular Mechanisms of Brain-aging

Aimi Syamima Abdul Manap
Amelia Cheng Wei Tan
Weng Hhin Leong
Adeline Yoke Yin Chia
Shantini Vijayabalan
Aditya Arya
Eng Hwa Wong
Farzana Rizwan
Umesh Bindal
Shajan Koshy

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2019.00206

21,391 views
90 citations

Original Research

Published on 31 Jul 2019

Dentate Gyrus Peroxiredoxin 6 Levels Discriminate Aged Unimpaired From Impaired Rats in a Spatial Memory Task

in Cellular and Molecular Mechanisms of Brain-aging

Jana Lubec
Roman Smidak
Jovana Malikovic
Daniel Daba Feyissa
Volker Korz
Harald Höger
Gert Lubec

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2019.00198

5,643 views
22 citations

Original Research

Published on 31 Jul 2019

Exploring the Mitochondrial Degradome by the TAILS Proteomics Approach in a Cellular Model of Parkinson’s Disease

in Cellular and Molecular Mechanisms of Brain-aging

Marta Lualdi
Maurizio Ronci
Mara Zilocchi
Federica Corno
Emily S. Turilli
Mauro Sponchiado
Antonio Aceto
Tiziana Alberio
Mauro Fasano

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2019.00195

6,809 views
11 citations

Mini Review

Published on 30 Jul 2019

Age-Related Functional and Expressional Changes in Efflux Pathways at the Blood-Brain Barrier

in Cellular and Molecular Mechanisms of Brain-aging

Franciska Erdő
Péter Krajcsi

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2019.00196

9,058 views
69 citations

Original Research

Published on 25 Jul 2019

Endogenous HCN Channels Modulate the Firing Activity of Globus Pallidus Neurons in Parkinsonian Animals

in Cellular and Molecular Mechanisms of Brain-aging

Xiao-Meng Hao
Rong Xu
An-Qi Chen
Feng-Jiao Sun
Ying Wang
Hong-Xia Liu
Hua Chen
Yan Xue
Lei Chen

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2019.00190

4,661 views
15 citations

Original Research

Published on 17 Jul 2019

Identification of the Potential Key Long Non-coding RNAs in Aged Mice With Postoperative Cognitive Dysfunction

in Cellular and Molecular Mechanisms of Brain-aging

Ming Li
Chan Chen
Weiyi Zhang
Rui Gao
Qiao Wang
Hai Chen
Shu Zhang
Xiaobo Mao
Mathis Leblanc
Adam Behensky

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2019.00181

6,328 views
29 citations

Original Research

Published on 12 Jul 2019

Neuroprotective Effects of Kinin B2 Receptor in Organotypic Hippocampal Cultures of Middle-Aged Mice

in Cellular and Molecular Mechanisms of Brain-aging

Mariana Toricelli
Sebastiana Ribeiro Evangelista
Larissa Rolim Oliveira
Tania Araujo Viel
Hudson Sousa Buck

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2019.00168

3,894 views
6 citations

Original Research

Published on 04 Jul 2019

3D Reconstruction of the Neurovascular Unit Reveals Differential Loss of Cholinergic Innervation in the Cortex and Hippocampus of the Adult Mouse Brain

in Cellular and Molecular Mechanisms of Brain-aging

Shereen Nizari
Roxana O. Carare
Ignacio A. Romero
Cheryl A. Hawkes

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2019.00172

6,838 views
23 citations

Review

Published on 02 Jul 2019

Decoding the Role of Platelets and Related MicroRNAs in Aging and Neurodegenerative Disorders

in Cellular and Molecular Mechanisms of Brain-aging

Yolanda Espinosa-Parrilla
Christian Gonzalez-Billault
Eduardo Fuentes
Ivan Palomo
Marcelo Alarcón

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2019.00151

13,679 views
40 citations

Original Research

Published on 26 Jun 2019

Synaptopathy as a Mechanism for Age-Related Vestibular Dysfunction in Mice

in Cellular and Molecular Mechanisms of Brain-aging

Guoqiang Wan
Lingchao Ji
Thomas Schrepfer
Sihao Gong
Guo-Peng Wang
Gabriel Corfas

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2019.00156

7,770 views
32 citations

Original Research

Published on 19 Jun 2019

A Novel in vivo Anti-amnesic Agent, Specially Designed to Express Both Acetylcholinesterase (AChE) Inhibitory, Serotonergic Subtype 4 Receptor (5-HT4R) Agonist and Serotonergic Subtype 6 Receptor (5-HT6R) Inverse Agonist Activities, With a Potential Interest Against Alzheimer’s Disease

in Cellular and Molecular Mechanisms of Brain-aging

Bérénice Hatat
Samir Yahiaoui
Cédric Lecoutey
Audrey Davis
Thomas Freret
Michel Boulouard
Sylvie Claeysen
Christophe Rochais
Patrick Dallemagne

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2019.00148

4,987 views
25 citations

Hypothesis and Theory

Published on 13 Jun 2019

Involvement of microRNA-34a in Age-Related Susceptibility to Oxidative Stress in ARPE-19 Cells by Targeting the Silent Mating Type Information Regulation 2 Homolog 1/p66shc Pathway: Implications for Age-Related Macular Degeneration

in Cellular and Molecular Mechanisms of Brain-aging

Nianting Tong
Rong Jin
Zhanyu Zhou
Xingwei Wu

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2019.00137

5,158 views
21 citations

Mini Review

Published on 11 Jun 2019

Sleep, Aging, and Cellular Health: Aged-Related Changes in Sleep and Protein Homeostasis Converge in Neurodegenerative Diseases

in Cellular and Molecular Mechanisms of Brain-aging

Jennifer M. Hafycz
Nirinjini N. Naidoo

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2019.00140

8,828 views
23 citations

749 articles

articles

Inhibition of AMD-Like Pathology With a Neurotrophic Compound in Aged Rats and 3xTg-AD Mice

SIRT3 Regulation of Mitochondrial Quality Control in Neurodegenerative Diseases

Proteome Profiling of Cerebral Vessels in Rhesus Macaques: Dysregulation of Antioxidant Activity and Extracellular Matrix Proteins Contributes to Cerebrovascular Aging in Rhesus Macaques

Attenuating Cholinergic Transmission Increases the Number of Satellite Cells and Preserves Muscle Mass in Old Age

Age and Ketogenic Diet Have Dissociable Effects on Synapse-Related Gene Expression Between Hippocampal Subregions

In vivo Bioluminescence Imaging Used to Monitor Disease Activity and Therapeutic Response in a Mouse Model of Tauopathy

A Pilot Study Investigating Changes in the Human Plasma and Urine NAD+ Metabolome During a 6 Hour Intravenous Infusion of NAD+

Memory Decline and Behavioral Inflexibility in Aged Mice Are Correlated With Dysregulation of Protein Synthesis Capacity

Appoptosin Mediates Lesions Induced by Oxidative Stress Through the JNK-FoxO1 Pathway

Novel Functions of the Neurodegenerative-Related Gene Tau in Cancer

Exosome Determinants of Physiological Aging and Age-Related Neurodegenerative Diseases

Synergistic Effects of Curcumin and Piperine as Potent Acetylcholine and Amyloidogenic Inhibitors With Significant Neuroprotective Activity in SH-SY5Y Cells via Computational Molecular Modeling and in vitro Assay

Dentate Gyrus Peroxiredoxin 6 Levels Discriminate Aged Unimpaired From Impaired Rats in a Spatial Memory Task

Exploring the Mitochondrial Degradome by the TAILS Proteomics Approach in a Cellular Model of Parkinson’s Disease

Age-Related Functional and Expressional Changes in Efflux Pathways at the Blood-Brain Barrier

Endogenous HCN Channels Modulate the Firing Activity of Globus Pallidus Neurons in Parkinsonian Animals

Identification of the Potential Key Long Non-coding RNAs in Aged Mice With Postoperative Cognitive Dysfunction

Neuroprotective Effects of Kinin B2 Receptor in Organotypic Hippocampal Cultures of Middle-Aged Mice

3D Reconstruction of the Neurovascular Unit Reveals Differential Loss of Cholinergic Innervation in the Cortex and Hippocampus of the Adult Mouse Brain

Decoding the Role of Platelets and Related MicroRNAs in Aging and Neurodegenerative Disorders

Synaptopathy as a Mechanism for Age-Related Vestibular Dysfunction in Mice

A Novel in vivo Anti-amnesic Agent, Specially Designed to Express Both Acetylcholinesterase (AChE) Inhibitory, Serotonergic Subtype 4 Receptor (5-HT4R) Agonist and Serotonergic Subtype 6 Receptor (5-HT6R) Inverse Agonist Activities, With a Potential Interest Against Alzheimer’s Disease

Involvement of microRNA-34a in Age-Related Susceptibility to Oxidative Stress in ARPE-19 Cells by Targeting the Silent Mating Type Information Regulation 2 Homolog 1/p66shc Pathway: Implications for Age-Related Macular Degeneration

Sleep, Aging, and Cellular Health: Aged-Related Changes in Sleep and Protein Homeostasis Converge in Neurodegenerative Diseases