Frontiers in Aging Neuroscience | Parkinson’s Disease and Aging-related Movement Disorders

Original Research

Published on 16 Dec 2025

A lightweight cerebrospinal fluid biomarker-based model for first-diagnosis prediction of Parkinson’s disease: model development, external validation, and local deployment

in Parkinson’s Disease and Aging-related Movement Disorders

Xinchao Hu
Yu Liu
Yuan Cao
Chunli Wei
Kun Liu
Jing-Hua Yang

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1723169

383 views

Original Research

Accepted on 15 Dec 2025

ParkXplainer: An Interpretable Ensemble Learning Driven Approach for Hand-drawn Image based Early Parkinson's Detection using Grad-CAM

in Parkinson’s Disease and Aging-related Movement Disorders

Gayatri Saxena
Seema Bawa
Rohit Ahuja

Frontiers in Aging Neuroscience

Systematic Review

Published on 15 Dec 2025

Transcranial stimulation combined with four rehabilitation therapies for gait and motor function in Parkinson’s disease: a network meta-analysis of 23 RCTs

in Parkinson’s Disease and Aging-related Movement Disorders

Dongyue Li
Xinyu Lin
Haojie Li
Jian Zhou

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1670825

188 views

Original Research

Published on 12 Dec 2025

Association between motor symptom severity and urinary dysfunction in Parkinson’s disease: a retrospective study

in Parkinson’s Disease and Aging-related Movement Disorders

Jun Seok Lee
Joonsang Yoo
Nak-Hoon Son
Hye Jin Byun
Sooyeoun You

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1688656

395 views

Mini Review

Published on 12 Dec 2025

Pterostilbene restores mitochondrial retrograde signaling to activate protective stress responses in Parkinson’s disease

in Parkinson’s Disease and Aging-related Movement Disorders

Fanshuai Zeng
Wei Li
Liyue Yang
Lu Yao
Xinna Wang

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1692777

521 views

Review

Published on 12 Dec 2025

Parkinson’s disease physiopathology—beyond the α-synuclein aggregation: a narrative review

in Parkinson’s Disease and Aging-related Movement Disorders

Victor Fellipe Bispo Macedo
Vanessa Karine Bispo Macedo
Jorge Artur Peçanha de Miranda Coelho
Alana Madeiro de Melo Barboza

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1664269

409 views

Original Research

Accepted on 11 Dec 2025

18F-FDG PET/MR reveals specific brain metabolic features in Parkinson's disease with frailty

in Parkinson’s Disease and Aging-related Movement Disorders

Guoyang LI
Wenli Zhang
Fengju Mao
Hong Zhao
Long Zhao
Yang Yang
Chang Sun
Lu Liu
Xiangcheng Wang
Xiaoguang Luo

Frontiers in Aging Neuroscience

105 views

Systematic Review

Published on 11 Dec 2025

Machine learning methods for the detection and prediction of cognitive impairment in Parkinson’s disease: a systematic review and meta-analysis

in Parkinson’s Disease and Aging-related Movement Disorders

Hong Jiang
Xinling Yang
Wenxing Wang
Lin Jiang
Xiao’e Jiang

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1704039

368 views

Original Research

Published on 09 Dec 2025

Enhanced Parkinson's disease prediction using LDEFS feature selection and Mamdani fuzzy neural network

in Parkinson’s Disease and Aging-related Movement Disorders

M. Vijayalakshmi
B. Dhiyanesh
D. Viji
P. Saranya

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1665590

344 views

Original Research

Accepted on 08 Dec 2025

Separating Cognitive and Motor Contributions to iADL Difficulties in Parkinson's Disease

in Parkinson’s Disease and Aging-related Movement Disorders

Rekha Ravikumar
Marta Statucka
Melanie Cohn

Frontiers in Aging Neuroscience

113 views

Original Research

Published on 08 Dec 2025

Clinical analysis of sarcopenia prevalence and its influencing factors in patients with Parkinson’s disease

in Parkinson’s Disease and Aging-related Movement Disorders

Remi Morimoto
Kazuo Kitagawa
Kenichi Todo
Mutsumi Iijima

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1718723

567 views

Original Research

Published on 08 Dec 2025

A nomogram based on coagulation markers for predicting meige syndrome risk

in Parkinson’s Disease and Aging-related Movement Disorders

Yuanyuan Chen
Yuehua Sun
Xinyu Zhang
Yang Chen
Shuai Zhao
Mengyao Shi
Xuefeng Lv
Wenping Lian
Zhongquan Wang
Yongjun Wu

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1665276

560 views

Original Research

Accepted on 05 Dec 2025

Altered resting-state functional connectivity of raphe nucleus is associated with tremor in Parkinson's disease

in Parkinson’s Disease and Aging-related Movement Disorders

Qianyi Zheng
Dongling Zhang
Junyan Sun
Junling Wang
Lili Chen
Xuemei Wang
Tao Wu

Frontiers in Aging Neuroscience

221 views

Original Research

Accepted on 03 Dec 2025

Integrated bioinformatics analysis reveals Netrin-1 as a key molecular link between Parkinson's disease and heart failure

in Parkinson’s Disease and Aging-related Movement Disorders

Zhen Ni
Gaoge Wang
Yingyan Li
Huan Chen
Hou Hongwei
Qingyuan Hu

Frontiers in Aging Neuroscience

109 views

Original Research

Published on 03 Dec 2025

Abnormal subthalamic nucleus functional connectivity and machine learning classification in Parkinson’s disease: a multisite functional magnetic resonance imaging study

in Parkinson’s Disease and Aging-related Movement Disorders

Bin Qin
Yisi Tang
Huixun Qin
Wen Gao
Shusheng Liao
Mingxiu Yang

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1695806

385 views

Original Research

Published on 02 Dec 2025

Correlation between cerebral small vessel disease and postural instability/gait difficulty subtype in Parkinson’s disease patients

in Parkinson’s Disease and Aging-related Movement Disorders

Yingchao Ge
Wa Zhao
Xiaorong Xu
Wenchao Qiu
Peiting Liu
Minghui Zhao
Yongqing Cheng
Shouru Xue

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1686214

422 views

Original Research

Published on 01 Dec 2025

Impact of aging on the central and enteric nervous system in a Parkinson’s disease mouse model

in Parkinson’s Disease and Aging-related Movement Disorders

Solène Pradeloux
Morgane M. André
Maélie Fréchette
Mathilde Drolet
Catherine Fontaine-Lavallée
Mélissa Côté
Katherine Coulombe
Marie Rieux
Frédéric Calon
Denis Soulet

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1576325

822 views

Review

Published on 28 Nov 2025

Development and emerging trends in gastrointestinal dysfunction of Parkinson’s disease: a decade-long bibliometric analysis

in Parkinson’s Disease and Aging-related Movement Disorders

Yujia Sun
Haoyu Yang
Junfeng Zhang
Shan Cong
Lin Wang
Tao Yu

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1712302

680 views

Original Research

Accepted on 27 Nov 2025

Machine Learning Models for the Prediction of Levodopa Response to Tremor in Parkinson's Disease

in Parkinson’s Disease and Aging-related Movement Disorders

Fangfei Li
Shinuan Lin
Rui Yan
Yusha Cui
Kang Ren
Zhonglue Chen
Lingyan Ma
Tao Feng

Frontiers in Aging Neuroscience

129 views

Original Research

Published on 26 Nov 2025

Absence of the LRRK2 mutation in Emirati Parkinson’s disease patients in contrast to other Arab populations

in Parkinson’s Disease and Aging-related Movement Disorders

Vinod Metta
Anjana Soorajkumar
Tom Loney
Nasna Nassir
K. Ray Chaudhuri
Mohammed Jashim Uddin
Hani T. S. Benamer

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1676115

612 views

Original Research

Accepted on 25 Nov 2025

Quantity and quality of care and staff knowledge regarding people with Parkinson's disease in long-term nursing care—"real-life" results from the German Care4PD study

in Parkinson’s Disease and Aging-related Movement Disorders

Odette Fründt
Verena Caroline Lamb
Anne-Marie Hanff
Tobias Mai
Christiane Kirchner
Ali Amouzandeh
Carsten Buhmann
Rejko Krüger
Alfons Schnitzler
Martin Südmeyer

Frontiers in Aging Neuroscience

125 views

Original Research

Published on 25 Nov 2025

VPS35 D620N mutation impairs neurogenesis and promotes ferroptosis in Parkinson’s disease by using molecular docking, molecular dynamic simulation, and cellular model

in Parkinson’s Disease and Aging-related Movement Disorders

Mei Jiang
Xu Deng
Zijie Qiu
Yuan Fu
Zixiong Qiu
Jiankai Zhang
Hongxia Fu
Jie Li
Yao Luo
Xiaojun Cui

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1692687

737 views

Original Research

Published on 25 Nov 2025

Multimodal MRI reveals distinct hippocampal subregional alterations in de novo Parkinson’s disease across the cognitive spectrum

in Parkinson’s Disease and Aging-related Movement Disorders

Chenxi Pan
Enchun Zhao
Jingru Ren
Gaiyan Zhou
Yajie Wang
Ronggui Zhang
Yang Shen
Weiguo Liu
Jiu Chen

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1685244

554 views

Review

Published on 21 Nov 2025

Exercise regulates mitophagy to alleviate parkinsonian neurodegeneration

in Parkinson’s Disease and Aging-related Movement Disorders

Chang Liu
Wei He
JianHua Zhang

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1678460

1,118 views

986 articles

articles

A lightweight cerebrospinal fluid biomarker-based model for first-diagnosis prediction of Parkinson’s disease: model development, external validation, and local deployment

ParkXplainer: An Interpretable Ensemble Learning Driven Approach for Hand-drawn Image based Early Parkinson's Detection using Grad-CAM

Transcranial stimulation combined with four rehabilitation therapies for gait and motor function in Parkinson’s disease: a network meta-analysis of 23 RCTs

Association between motor symptom severity and urinary dysfunction in Parkinson’s disease: a retrospective study

Pterostilbene restores mitochondrial retrograde signaling to activate protective stress responses in Parkinson’s disease

Parkinson’s disease physiopathology—beyond the α-synuclein aggregation: a narrative review

18F-FDG PET/MR reveals specific brain metabolic features in Parkinson's disease with frailty

Machine learning methods for the detection and prediction of cognitive impairment in Parkinson’s disease: a systematic review and meta-analysis

Enhanced Parkinson's disease prediction using LDEFS feature selection and Mamdani fuzzy neural network

Separating Cognitive and Motor Contributions to iADL Difficulties in Parkinson's Disease

Clinical analysis of sarcopenia prevalence and its influencing factors in patients with Parkinson’s disease

A nomogram based on coagulation markers for predicting meige syndrome risk

Altered resting-state functional connectivity of raphe nucleus is associated with tremor in Parkinson's disease

Integrated bioinformatics analysis reveals Netrin-1 as a key molecular link between Parkinson's disease and heart failure

Abnormal subthalamic nucleus functional connectivity and machine learning classification in Parkinson’s disease: a multisite functional magnetic resonance imaging study

Correlation between cerebral small vessel disease and postural instability/gait difficulty subtype in Parkinson’s disease patients

Impact of aging on the central and enteric nervous system in a Parkinson’s disease mouse model

Development and emerging trends in gastrointestinal dysfunction of Parkinson’s disease: a decade-long bibliometric analysis

Machine Learning Models for the Prediction of Levodopa Response to Tremor in Parkinson's Disease

Absence of the LRRK2 mutation in Emirati Parkinson’s disease patients in contrast to other Arab populations

Quantity and quality of care and staff knowledge regarding people with Parkinson's disease in long-term nursing care—"real-life" results from the German Care4PD study

VPS35 D620N mutation impairs neurogenesis and promotes ferroptosis in Parkinson’s disease by using molecular docking, molecular dynamic simulation, and cellular model

Multimodal MRI reveals distinct hippocampal subregional alterations in de novo Parkinson’s disease across the cognitive spectrum

Exercise regulates mitophagy to alleviate parkinsonian neurodegeneration