Frontiers in Aging Neuroscience

Review

Published on 10 Feb 2026

Astaxanthin as a neuroprotective modulator of synaptic plasticity, learning, and memory: mechanistic insights and therapeutic perspectives in neurodegenerative aging

Fan Guo
Jiapei Chi

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1737001

1,413 views

Original Research

Published on 02 Feb 2026

Associations between declines in uneven terrain walking speed and visuospatial working memory in older adults

Jungyun Hwang
Chang Liu
Steven P. Winesett
Tyler Fettow
Valay A. Shah
Sudeshna A. Chatterjee
Todd M. Manini
Chris J. Hass
Rachael D. Seidler
Daniel P. Ferris

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1644741

770 views

Original Research

Published on 30 Jan 2026

The effect of hearing ability on dual-task performance following multi-domain training in older adults with mild cognitive impairment: findings from the SYNERGIC trial

Rachel I. Downey
Berkley J. Petersen
Niroshica Mohanathas
Jennifer L. Campos
Manuel Montero-Odasso
Louis Bherer
M. Kathleen Pichora-Fuller
Nick W. Bray
Amer M. Burhan
Richard Camicioli

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1716733

672 views

Review

Published on 29 Jan 2026

Gut-kidney-brain axis and daytime sleepiness in Parkinson's disease and chronic kidney disease: an expert narrative review

Shanshan Yang
Canmin Zhu
Shihong Xiong
Xinyue Wang
Ke Cheng
Yuxin Wang
Na Gong

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1728664

606 views

Original Research

Published on 29 Jan 2026

Trends and cross-country inequalities in the global burden of Alzheimer’s disease and other dementias among adults aged 65+ years, 1990–2021: a population based study with projections into 2050

Sibo Liu
Guozhi Wu
Xiao Ma
Kai Xu
Xiaoyan Lan
Long Wang
Hang Li
Dean Gu
Mengxing Wang
Jinjie Liu

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1683158

778 views

Original Research

Published on 27 Jan 2026

Leveraging object detection for early diagnosis of neurodegenerative diseases through radiomic analysis

Wenhong Zhi
Zhiguang Liu
Linjian Huang
Miaoran Li
Xin Xu
Zhijian Xi

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1645118

874 views

Original Research

Published on 27 Jan 2026

Gamma-aminobutyric acid associated research in Parkinson’s disease: an exploratory trends analysis

Sheng-Qiang Zhou
Fang Liu
Yan-Jun Chen
Ming-Rong Xie

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1655660

1,118 views

Systematic Review

Published on 23 Jan 2026

The effects of video games on cognitive function in older adults with mild cognitive impairment: a meta-analysis

Bo Liu
Xiaomei Li
Hejia Cai

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1756970

1,234 views

Editorial

Published on 23 Jan 2026

Editorial: Preserving emotional health in aging: unraveling the neural mechanisms and implications for neurodegenerative diseases

Quelen Iane Garlet
Daniel Felsky
Kiyotaka Nemoto

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1772872

848 views

Original Research

Published on 22 Jan 2026

18F-FDG PET/MR reveals specific brain metabolic features in Parkinson’s disease with frailty

Guoyang Li
Wenli Zhang
Fengju Mao
Hong Zhao
Long Zhao
Yang Yang
Chang Sun
Lu Liu
Xiangcheng Wang
Xiaoguang Luo

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1624203

693 views

Systematic Review

Published on 22 Jan 2026

Effects of different types of deep brain stimulation on gait disorders in patients with Parkinson’s disease: a network meta-analysis of randomized controlled trials

Yunpeng Guo
Zhanyi Zhang
Yixian Hou

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1723706

769 views

Original Research

Published on 21 Jan 2026

Older adult solitary drinking: associations with subjective and objective cognitive functioning

Carillon J. Skrzynski
Angela D. Bryan

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1678121

1,151 views

Original Research

Published on 20 Jan 2026

Predicting progression from amnestic mild cognitive impairment to Alzheimer's disease using longitudinal EEG data: a 12-month cohort study

Yingfeng Ge
Yi Fei
Chonglong Ding
Shuo Yang
Yingying Fang
Yifan Zheng
Jianan Yin
Qi Pan
Nanxiang Zhang
Xiaohao Zhang

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1719981

841 views

Original Research

Published on 20 Jan 2026

White matter hyperintensities and late-life cognition: an analysis of moderation effects of mild behavioral impairment

Jiayu Duan
Ningqun Wang
Shixin Li
Yefei Wang
Jiale Song
Xiaoshan Li
Jingrui Guo
Junya Liao
Yihan Wang
Ying Zhang

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1675465

681 views

Review

Published on 20 Jan 2026

Mechanisms to medicines: navigating drug repurposing strategies in Alzheimer’s disease

Sara Akhtar Khan
Khushi Raza
Prachi Tiwari
Mohamed El-Tanani
Syed Arman Rabbani
Suhel Parvez

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1676065

1,270 views

Mini Review

Published on 20 Jan 2026

Human cytomegalovirus infection and cognitive decline: insights from population and experimental studies

Koon Chu Yaiw
Isidre A. Ferrer
Cecilia Söderberg-Nauclér
Dorota Religa

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1757461

685 views

Review

Published on 20 Jan 2026

Intestinal barrier compromise, viral persistence, and immune dysregulation converge on neurological sequelae in Long COVID

Laurence Leclerc
Johanne Poudrier
Christopher Power
Grace Y. Lam
Emilia Liana Falcone

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1744415

5,650 views

Hypothesis and Theory

Published on 20 Jan 2026

Therapeutic and preventive strategies based on the maladaptive plasticity hypothesis for Alzheimer’s disease

Shigeki Kawabata

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1726144

722 views

Brief Research Report

Published on 16 Jan 2026

After cochlear implantation in older adults, enhanced working memory does not fully mediate the relationship between CI and improved semantic fluency

Maria Huber
Angelika Illg
Lisa Reuter
Lennart Weitgasser

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1701934

675 views

Review

Published on 16 Jan 2026

Research progress on 40 Hz sensory stimulation for the treatment of Alzheimer’s disease

Bing Tang
Ming Tao

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1710041

3,026 views

Systematic Review

Published on 16 Jan 2026

The validity of visual and hearing impairment in predicting dementia and cognitive impairment in older adults: a systematic review and meta-analysis

Qingwen Gan
Yiling Yuan
Qianqian Hu
Yonghui Zhang

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1656686

1,125 views

Original Research

Published on 15 Jan 2026

Early and progressive retinal microglial changes in APPNL-F/NL-F mouse model of Alzheimer’s disease revealed by an automated image analysis software

Lidia Sánchez-Puebla
Inés López-Cuenca
Miguel A. Sánchez-Puebla
Ana Granados
Ana I. Ramírez
Juan Llorens
Takaomi C. Saido
Takashi Saito
Carmen Nieto-Vaquero
María A. Moro

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1712480

1,393 views

Original Research

Published on 15 Jan 2026

Polarity-dependent modulation of sleep oscillations and cortical excitability in aging

Buse Dikici
Robert Malinowski
Jan-Bernhard Kordaß
Klaus Obermayer
Julia Ladenbauer
Agnes Flöel

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1704130

726 views

Review

Published on 15 Jan 2026

Effect of deep brain stimulation on dysphagia in Parkinson’s disease: mechanisms, evidence, and outlook

Jule Hofacker
Bahne H. Bahners
Cinja Huber
Christian J. Hartmann
Inga Claus
Sonja Suntrup-Krueger
Alfons Schnitzler
Tobias Warnecke
Bendix Labeit

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1734432

1,220 views

746 Publications

volumes

Astaxanthin as a neuroprotective modulator of synaptic plasticity, learning, and memory: mechanistic insights and therapeutic perspectives in neurodegenerative aging

Associations between declines in uneven terrain walking speed and visuospatial working memory in older adults

The effect of hearing ability on dual-task performance following multi-domain training in older adults with mild cognitive impairment: findings from the SYNERGIC trial

Gut-kidney-brain axis and daytime sleepiness in Parkinson's disease and chronic kidney disease: an expert narrative review

Trends and cross-country inequalities in the global burden of Alzheimer’s disease and other dementias among adults aged 65+ years, 1990–2021: a population based study with projections into 2050

Leveraging object detection for early diagnosis of neurodegenerative diseases through radiomic analysis

Gamma-aminobutyric acid associated research in Parkinson’s disease: an exploratory trends analysis

The effects of video games on cognitive function in older adults with mild cognitive impairment: a meta-analysis

Editorial: Preserving emotional health in aging: unraveling the neural mechanisms and implications for neurodegenerative diseases

18F-FDG PET/MR reveals specific brain metabolic features in Parkinson’s disease with frailty

Effects of different types of deep brain stimulation on gait disorders in patients with Parkinson’s disease: a network meta-analysis of randomized controlled trials

Older adult solitary drinking: associations with subjective and objective cognitive functioning

Predicting progression from amnestic mild cognitive impairment to Alzheimer's disease using longitudinal EEG data: a 12-month cohort study

White matter hyperintensities and late-life cognition: an analysis of moderation effects of mild behavioral impairment

Mechanisms to medicines: navigating drug repurposing strategies in Alzheimer’s disease

Human cytomegalovirus infection and cognitive decline: insights from population and experimental studies

Intestinal barrier compromise, viral persistence, and immune dysregulation converge on neurological sequelae in Long COVID

Therapeutic and preventive strategies based on the maladaptive plasticity hypothesis for Alzheimer’s disease

After cochlear implantation in older adults, enhanced working memory does not fully mediate the relationship between CI and improved semantic fluency

Research progress on 40 Hz sensory stimulation for the treatment of Alzheimer’s disease

The validity of visual and hearing impairment in predicting dementia and cognitive impairment in older adults: a systematic review and meta-analysis

Early and progressive retinal microglial changes in APPNL-F/NL-F mouse model of Alzheimer’s disease revealed by an automated image analysis software

Polarity-dependent modulation of sleep oscillations and cortical excitability in aging

Effect of deep brain stimulation on dysphagia in Parkinson’s disease: mechanisms, evidence, and outlook

volumes

Astaxanthin as a neuroprotective modulator of synaptic plasticity, learning, and memory: mechanistic insights and therapeutic perspectives in neurodegenerative aging

Associations between declines in uneven terrain walking speed and visuospatial working memory in older adults

The effect of hearing ability on dual-task performance following multi-domain training in older adults with mild cognitive impairment: findings from the SYNERGIC trial

Gut-kidney-brain axis and daytime sleepiness in Parkinson's disease and chronic kidney disease: an expert narrative review

Trends and cross-country inequalities in the global burden of Alzheimer’s disease and other dementias among adults aged 65+ years, 1990–2021: a population based study with projections into 2050

Leveraging object detection for early diagnosis of neurodegenerative diseases through radiomic analysis

Gamma-aminobutyric acid associated research in Parkinson’s disease: an exploratory trends analysis

The effects of video games on cognitive function in older adults with mild cognitive impairment: a meta-analysis

Editorial: Preserving emotional health in aging: unraveling the neural mechanisms and implications for neurodegenerative diseases

18F-FDG PET/MR reveals specific brain metabolic features in Parkinson’s disease with frailty

Effects of different types of deep brain stimulation on gait disorders in patients with Parkinson’s disease: a network meta-analysis of randomized controlled trials

Older adult solitary drinking: associations with subjective and objective cognitive functioning

Predicting progression from amnestic mild cognitive impairment to Alzheimer's disease using longitudinal EEG data: a 12-month cohort study

White matter hyperintensities and late-life cognition: an analysis of moderation effects of mild behavioral impairment

Mechanisms to medicines: navigating drug repurposing strategies in Alzheimer’s disease

Human cytomegalovirus infection and cognitive decline: insights from population and experimental studies

Intestinal barrier compromise, viral persistence, and immune dysregulation converge on neurological sequelae in Long COVID

Therapeutic and preventive strategies based on the maladaptive plasticity hypothesis for Alzheimer’s disease

After cochlear implantation in older adults, enhanced working memory does not fully mediate the relationship between CI and improved semantic fluency

Research progress on 40 Hz sensory stimulation for the treatment of Alzheimer’s disease

The validity of visual and hearing impairment in predicting dementia and cognitive impairment in older adults: a systematic review and meta-analysis

Early and progressive retinal microglial changes in APPNL-F/NL-F mouse model of Alzheimer’s disease revealed by an automated image analysis software

Polarity-dependent modulation of sleep oscillations and cortical excitability in aging

Effect of deep brain stimulation on dysphagia in Parkinson’s disease: mechanisms, evidence, and outlook

Research progress on 40 Hz sensory stimulation for the treatment of Alzheimer’s disease