Frontiers in Aging Neuroscience

Original Research

Accepted on 12 Dec 2025

Trends and cross-country inequalities in the global burden of Alzheimer's disease and other dementias among adults aged 65+ years, 1990-2021: a population based study with projections into 2050

Sibo Liu
Guozhi Wu
Xiao Ma
Kai Xu
Xiaoyan Lan
Long Wang
Hang Li
Dean Gu
Mengxing Wang
Jinjie Liu

Frontiers in Aging Neuroscience

Original Research

Accepted on 12 Dec 2025

Development and Validation of a Prognostic Nomogram for Predicting Ventilator-Associated Pneumonia Risk in Elderly Large Vessel Occlusion Ischemic Stroke after Endovascular Therapy Patients

Wenfei Liang
Jingling Zhu
Xiuling Yang
Xiaohua He
Guoshun Li
Zhaobang Chen
Jiasheng Zhao
Kangqiang Yang
Bin Liao
Huiquan Deng

Frontiers in Aging Neuroscience

Mini Review

Published on 12 Dec 2025

Pterostilbene restores mitochondrial retrograde signaling to activate protective stress responses in Parkinson’s disease

Fanshuai Zeng
Wei Li
Liyue Yang
Lu Yao
Xinna Wang

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1692777

382 views

Original Research

Published on 12 Dec 2025

Association between motor symptom severity and urinary dysfunction in Parkinson’s disease: a retrospective study

Jun Seok Lee
Joonsang Yoo
Nak-Hoon Son
Hye Jin Byun
Sooyeoun You

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1688656

229 views

Review

Published on 12 Dec 2025

Parkinson’s disease physiopathology—beyond the α-synuclein aggregation: a narrative review

Victor Fellipe Bispo Macedo
Vanessa Karine Bispo Macedo
Jorge Artur Peçanha de Miranda Coelho
Alana Madeiro de Melo Barboza

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1664269

252 views

Original Research

Published on 12 Dec 2025

Challenges in neuropsychological improvement after shunt surgery for idiopathic normal pressure hydrocephalus

Ondřej Rýdlo
Adéla Bubeníková
Petr Skalický
Klára Häcklová
Robért Leško
Aleš Vlasák
Hana Georgi
Ondřej Bradáč

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1725486

259 views

Original Research

Accepted on 11 Dec 2025

Subclinical Infection Combined with Surgery-Induced Cogni-tive Dysfunction: A Novel Adult Mouse Model for Periopera-tive Neurocognitive Disorder

Yizhe Zhang
Xiao Zhang
Wanbing Dai
Ye Liu
Xiangyang Cheng
Yeke Zhu
Lili Huang
Minghao Tang
Yongxing Yao
Xuwu Xiang

Frontiers in Aging Neuroscience

Correction

Accepted on 11 Dec 2025

Correction: Construction and validation of a cognitive frailty risk prediction model for elderly patients with colorectal cancer

Yu Wang
Li Wang
Yunhong Du
Xiaoye Ma
Lili Sun
Xiujie Zhang
Wenli Rong
Jianwei Li
Yao Shi
Wei Liu

Frontiers in Aging Neuroscience

Original Research

Accepted on 11 Dec 2025

Single-cell analysis of microglial activation after traumatic brain injury reveals immune signaling pathways linked to mitochondrial dysfunction and brain aging

Ming Sun
Chao Wu
Jingjing Wu
Lixin Liu
Liang Gu
Zihao Wang
Xue Yang
Feng Xu

Frontiers in Aging Neuroscience

Original Research

Accepted on 11 Dec 2025

The Alterations in Brain Network Functional Gradients and Dynamic Functional Connectivity in Alzheimer's Disease:A Resting-State fMRI Study

Benqin Liu
Chunbing Chen
Pan Cai
Jiaren Zhang
Yang Li
Xu Chen
Xuejin Ma
Xuetao Jiang
anjie zhang
Linfeng Song

Frontiers in Aging Neuroscience

Original Research

Accepted on 11 Dec 2025

18F-FDG PET/MR reveals specific brain metabolic features in Parkinson's disease with frailty

Guoyang LI
Wenli Zhang
Fengju Mao
Hong Zhao
Long Zhao
Yang Yang
Chang Sun
Lu Liu
Xiangcheng Wang
Xiaoguang Luo

Frontiers in Aging Neuroscience

Original Research

Published on 11 Dec 2025

Associations between the red blood cell distribution width and 30-day mortality in critically ill patients with delirium: a retrospective study using the MIMIC-IV database

Songmei Ma
Lin Lin
Shuwen Zheng
Zhenjing Liu
Li Kong
Haiyun Wang

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1599858

315 views

Systematic Review

Published on 11 Dec 2025

Machine learning methods for the detection and prediction of cognitive impairment in Parkinson’s disease: a systematic review and meta-analysis

Hong Jiang
Xinling Yang
Wenxing Wang
Lin Jiang
Xiao’e Jiang

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1704039

292 views

Original Research

Published on 10 Dec 2025

Exploring the Mahuang Fuzi Xixin Decoction’s mechanism for treating Alzheimer’s disease using molecular docking and network pharmacology

Che Chen
Qianfeng Shao
Sheng Zhou

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1688316

306 views

Original Research

Published on 10 Dec 2025

Safety and efficacy of extracranial vertebral artery stenting in elderly patients with symptomatic vertebral artery stenosis

Miao Wu
Zhiyong Zhang

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1667157

213 views

Original Research

Published on 10 Dec 2025

Amyloid pathology modulates the relationship between subsyndromal symptomatic depression and tau accumulation in non-demented older adults

Jiahe Bai
Xiaonan Wei
Hongchun Wei
Yaojun Tai
Min Kong
Maowen Ba
Chunhua Zhang

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1679285

280 views