Frontiers in Aging | Aging and the Immune System

Review

Published on 20 Oct 2025

Acid sensing to inflammaging: mechanisms and therapeutic promise of GPR68 (OGR1) in aging-related diseases

in Aging and the Immune System

Jianlei Wei
Fengxin Cui
Zhihua Huang
Zeping Li
Zebin Mao
Pengxia Zhang

Frontiers in Aging

doi 10.3389/fragi.2025.1684450

360 views

Hypothesis and Theory

Accepted on 13 Oct 2025

Estimation of Biological Aging Based on T Cell Differentiation Trajectories: Emerging and Future Avenues

in Aging and the Immune System

Aarav M Bhasin
Ishaan K Marwaha
Lahiri S Nooka

Frontiers in Aging

doi 10.3389/fragi.2025.1684051

211 views

Mini Review

Published on 13 Oct 2025

Drug-mediated disruption of the aging gut microbiota and mucosal immune system

in Aging and the Immune System

Lia Totleben
Joel Thomas
Daniel Austin

Frontiers in Aging

doi 10.3389/fragi.2025.1603847

682 views

Review

Published on 01 Oct 2025

Natural autoantibodies and their functional therapeutic roles in intravenous immunoglobulin

in Aging and the Immune System

Maria Giovanna Danieli
Ilaria Claudi
Elena Buti
Luca Gammeri
Sebastiano Gangemi
Yehuda Julyus Shoenfeld

Frontiers in Aging

doi 10.3389/fragi.2025.1682457

1,975 views

Perspective

Published on 30 Sep 2025

Inflammasome activation and accelerated immune aging in autoimmune disorders

in Aging and the Immune System

Rahul Mittal
Danay Saavedra
Mannat Mittal
Joana R. N. Lemos
Khemraj Hirani

Frontiers in Aging

doi 10.3389/fragi.2025.1688060

1,532 views

Original Research

Published on 11 Sep 2025

Immune indicators as predictors of cancer-related fatigue: a risk prediction model in pan-cancer patients

in Aging and the Immune System

Guixin He
Ting Ge
Baohui Wang
Jianchun Yu
Wentao Li

Frontiers in Aging

doi 10.3389/fragi.2025.1666116

1,111 views

Original Research

Published on 09 Sep 2025

Reversal of perturbed DNA damage response and HIV latency by a histone methyltransferase inhibitor in virally suppressed individuals living with HIV

in Aging and the Immune System

Pragati Chavan
Sathi Koar
Rohini Bingewar
Anuja Sonawane
Jyoti Sawant
Pallavi Shidhaye
Amrita Rao
Rajani Bagul
Ujjwala Ghule
Sunita Kumbhar

Frontiers in Aging

doi 10.3389/fragi.2025.1658506

1,241 views

Original Research

Published on 29 Jul 2025

Beta-hydroxybutyrate (BHB) elicits concentration-dependent anti-inflammatory effects on microglial cells which are reversible by blocking its monocarboxylate (MCT) importer

in Aging and the Immune System

Chase Garcia
Ariana Banerjee
Claire Montgomery
Lauren Adcock
Izumi Maezawa
Jon Ramsey
Ana Cristina G. Grodzki
Kyoungmi Kim
Gino Cortopassi

Frontiers in Aging

doi 10.3389/fragi.2025.1628835

2,726 views

Brief Research Report

Published on 20 May 2025

Hematopoietic stem cell size heterogeneity is not linked to changes in stem cell potential of aged HSCs

in Aging and the Immune System

Mehmet Saçma
Ali Hageb
Alex Zadro
Tanja Schuster
Mona Vogel
Karina Eiwen
Vadim Sakk
Hartmut Geiger

Frontiers in Aging

doi 10.3389/fragi.2025.1596565

2,997 views
1 citation

Systematic Review

Published on 10 Apr 2025

Global research trends in inflammaging from 2005 to 2024: a bibliometric analysis

in Aging and the Immune System

Beier Jiang
Yi-ni Dong
Yu Xiong
Chun-xia Jiang
Jun Ping
Qi Wu
Liu-jun Xu
Run-zhe Shu
Dan-dan Gao
Sheng-mei Zhu

Frontiers in Aging

doi 10.3389/fragi.2025.1554186

5,209 views
2 citations

Review

Published on 31 Mar 2025

Premature aging and metabolic diseases: the impact of telomere attrition

in Aging and the Immune System

Sandhya Jinesh
Burçin Özüpek
Prerana Aditi

Frontiers in Aging

doi 10.3389/fragi.2025.1541127

4,638 views
6 citations

Original Research

Published on 10 Mar 2025

Association of systemic immune-inflammatory index with all-cause and cancer mortality in Americans aged 60 years and older

in Aging and the Immune System

Wangfeng Lu
Yuliang Gong
Lei Liu
Yonghong Zhang
Xiaojian Tian
Huanxian Liu

Frontiers in Aging

doi 10.3389/fragi.2025.1502746

2,402 views
1 citation

Editorial

Published on 06 Feb 2025

Editorial: Pathogen-induced immunosenescence: where do vaccines stand?

in Aging and the Immune System

Mehrnoosh Doroudchi
Hamed Fouladseresht

Frontiers in Aging

doi 10.3389/fragi.2025.1560009

1,021 views

Original Research

Published on 05 Feb 2025

Investigating shared risk variants and genetic etiology between Alzheimer’s disease and three stress-related psychiatric disorders: a large-scale genome-wide cross-trait analysis

in Aging and the Immune System

Weijia Dang
Tianqi Hao
Ning Li
Hualin Zhang
Ziqi Li
Hongmei Yu
Yalu Wen
Deqiang Zheng
Long Liu

Frontiers in Aging

doi 10.3389/fragi.2025.1488528

2,777 views

Original Research

Published on 04 Feb 2025

Immunogenetics of longevity and its association with human endogenous retrovirus K

in Aging and the Immune System

Lisa M. James
Apostolos P. Georgopoulos

Frontiers in Aging

doi 10.3389/fragi.2025.1471202

2,214 views

Brief Research Report

Published on 23 Jan 2025

Markers of immunosenescence in CMV seropositive healthy elderly adults

in Aging and the Immune System

Ivón Johanna Rodríguez
Carlos Alberto Parra-López

Frontiers in Aging

doi 10.3389/fragi.2024.1436346

2,001 views
1 citation