Frontiers in Aging | Aging and the Immune System

Hypothesis and Theory

Published on 20 Nov 2025

Estimation of biological aging based on T-cell differentiation trajectories: emerging and future avenues

in Aging and the Immune System

Aarav M. Bhasin
Ishaan K. Marwaha
Lahiri S. Nooka

Frontiers in Aging

doi 10.3389/fragi.2025.1684051

334 views

Review

Accepted on 19 Nov 2025

Methylation and Algorithms in Biological Aging: A Scoping Review

in Aging and the Immune System

Alison Ziesel
Jennifer Reeves
Anastasia Mallidou
Lorelei Newton
Ryan E Rhodes
Jie Zhang
Theone Paterson
Hosna Jabbari

Frontiers in Aging

Correction

Published on 18 Nov 2025

Correction: Influence of circadian rhythm on the determination of the IMMune Age indeX (IMMAX)

in Aging and the Immune System

Sina Trebing
Peter Bröde
Maren Claus
Carsten Watzl

Frontiers in Aging

doi 10.3389/fragi.2025.1743195

201 views

Review

Published on 12 Nov 2025

Advanced immunology in aging population: unveiling the complexities of vaccine responsiveness

in Aging and the Immune System

Yan Han
Yanhao Huang
Yuanyu Zhou
Wanke He
Gaomei Luo
Liu Yang
Yanbin Chen
Yiqi Zhu
Wei Jiang
Chanchan Xiao

Frontiers in Aging

doi 10.3389/fragi.2025.1682763

544 views

Original Research

Published on 07 Nov 2025

Influence of circadian rhythm on the determination of the IMMune Age indeX (IMMAX)

in Aging and the Immune System

Sina Trebing
Peter Bröde
Maren Claus
Carsten Watzl

Frontiers in Aging

doi 10.3389/fragi.2025.1716985

770 views

Review

Accepted on 04 Nov 2025

The Gut-Brain Axis in Alzheimer's Disease: How Gut Microb iota Modulate Microglial Function

in Aging and the Immune System

HUAN WANG
FEIFAN YANG
Zhejianyi Gao
Zedong Cheng
Xicai Liang

Frontiers in Aging

129 views

Review

Published on 20 Oct 2025

Acid sensing to inflammaging: mechanisms and therapeutic promise of GPR68 (OGR1) in aging-related diseases

in Aging and the Immune System

Jianlei Wei
Fengxin Cui
Zhihua Huang
Zeping Li
Zebin Mao
Pengxia Zhang

Frontiers in Aging

doi 10.3389/fragi.2025.1684450

1,739 views

Mini Review

Published on 13 Oct 2025

Drug-mediated disruption of the aging gut microbiota and mucosal immune system

in Aging and the Immune System

Lia Totleben
Joel Thomas
Daniel Austin

Frontiers in Aging

doi 10.3389/fragi.2025.1603847

1,154 views

Review

Published on 01 Oct 2025

Natural autoantibodies and their functional therapeutic roles in intravenous immunoglobulin

in Aging and the Immune System

Maria Giovanna Danieli
Ilaria Claudi
Elena Buti
Luca Gammeri
Sebastiano Gangemi
Yehuda Julyus Shoenfeld

Frontiers in Aging

doi 10.3389/fragi.2025.1682457

2,601 views

Perspective

Published on 30 Sep 2025

Inflammasome activation and accelerated immune aging in autoimmune disorders

in Aging and the Immune System

Rahul Mittal
Danay Saavedra
Mannat Mittal
Joana R. N. Lemos
Khemraj Hirani

Frontiers in Aging

doi 10.3389/fragi.2025.1688060

2,307 views
1 citation

Original Research

Published on 11 Sep 2025

Immune indicators as predictors of cancer-related fatigue: a risk prediction model in pan-cancer patients

in Aging and the Immune System

Guixin He
Ting Ge
Baohui Wang
Jianchun Yu
Wentao Li

Frontiers in Aging

doi 10.3389/fragi.2025.1666116

1,503 views

Original Research

Published on 09 Sep 2025

Reversal of perturbed DNA damage response and HIV latency by a histone methyltransferase inhibitor in virally suppressed individuals living with HIV

in Aging and the Immune System

Pragati Chavan
Sathi Koar
Rohini Bingewar
Anuja Sonawane
Jyoti Sawant
Pallavi Shidhaye
Amrita Rao
Rajani Bagul
Ujjwala Ghule
Sunita Kumbhar

Frontiers in Aging

doi 10.3389/fragi.2025.1658506

1,400 views

Original Research

Published on 29 Jul 2025

Beta-hydroxybutyrate (BHB) elicits concentration-dependent anti-inflammatory effects on microglial cells which are reversible by blocking its monocarboxylate (MCT) importer

in Aging and the Immune System

Chase Garcia
Ariana Banerjee
Claire Montgomery
Lauren Adcock
Izumi Maezawa
Jon Ramsey
Ana Cristina G. Grodzki
Kyoungmi Kim
Gino Cortopassi

Frontiers in Aging

doi 10.3389/fragi.2025.1628835

3,233 views

Brief Research Report

Published on 20 May 2025

Hematopoietic stem cell size heterogeneity is not linked to changes in stem cell potential of aged HSCs

in Aging and the Immune System

Mehmet Saçma
Ali Hageb
Alex Zadro
Tanja Schuster
Mona Vogel
Karina Eiwen
Vadim Sakk
Hartmut Geiger

Frontiers in Aging

doi 10.3389/fragi.2025.1596565

3,266 views
2 citations

Systematic Review

Published on 10 Apr 2025

Global research trends in inflammaging from 2005 to 2024: a bibliometric analysis

in Aging and the Immune System

Beier Jiang
Yi-ni Dong
Yu Xiong
Chun-xia Jiang
Jun Ping
Qi Wu
Liu-jun Xu
Run-zhe Shu
Dan-dan Gao
Sheng-mei Zhu

Frontiers in Aging

doi 10.3389/fragi.2025.1554186

5,807 views
3 citations

Review

Published on 31 Mar 2025

Premature aging and metabolic diseases: the impact of telomere attrition

in Aging and the Immune System

Sandhya Jinesh
Burçin Özüpek
Prerana Aditi

Frontiers in Aging

doi 10.3389/fragi.2025.1541127

5,366 views
7 citations