Frontiers in Aging | Aging and the Immune System

Original Research

Published on 02 Feb 2026

Phenotypic and functional heterogeneity of naïve CD8+ T cells in human peripheral blood during aging

in Aging and the Immune System

Luca Pangrazzi
Patrizia Pehl
Lotti Hoffmann
Martin Bachmann
Gabriele Chelini
Michael Keller
Brigitte Jenewein
Maria Cavinato
Birgit Weinberger

Frontiers in Aging

doi 10.3389/fragi.2026.1765665

189 views

Opinion

Published on 21 Jan 2026

Age-associated B cells and double-negative B cells: two sides of the same coin? The answer depends on the context

in Aging and the Immune System

Malamatenia Lamprinou
Athanasios Sachinidis
Theodoros Dimitroulas

Frontiers in Aging

doi 10.3389/fragi.2026.1752452

494 views

Editorial

Published on 20 Jan 2026

Editorial: Cancer biology, immunotherapy and aging

in Aging and the Immune System

Stephane Koda
Jensen G. Weedor
Parfait Botolo Sakava

Frontiers in Aging

doi 10.3389/fragi.2026.1776719

494 views

Editorial

Published on 13 Jan 2026

Editorial: Immune senescence: a key driver of aging and age-related disorders

in Aging and the Immune System

Jing Luan
Bryan Wu
Xingchun Gao

Frontiers in Aging

doi 10.3389/fragi.2026.1776990

660 views

Original Research

Published on 12 Jan 2026

New insights into the association between cardiometabolic index with metabolic profile, nutritional status, and inflammaging in older adults

in Aging and the Immune System

Sylvia Ramuth
Rafael Leite Carvalho
Rafael Zappitelli Moscogliato
Marcelo Rossi
Luiz Henrique da Silva Nali
Patrícia Colombo-Souza
Jônatas Bussador Do Amaral
Guilherme Eustáquio Furtado
Tábatta Renata Pereira de Brito
André Luis Lacerda Bachi

Frontiers in Aging

doi 10.3389/fragi.2025.1699767

781 views

Review

Published on 08 Jan 2026

Global research landscape of telomere biology in infectious diseases: mechanistic links between host–pathogen interactions and immune ageing

in Aging and the Immune System

Theophilus Nang Wakai
Nina Ghislaine Yensii
Fabrice Banadzem Kernyuy
Mercy Bella-Omunagbe
Shalom Nwodo Chinedu
Israel Sunmola Afolabi

Frontiers in Aging

doi 10.3389/fragi.2025.1729868

1,219 views
1 citation

Review

Accepted on 26 Dec 2025

The gut and circulating virome: emerging players in aging and longevity

in Aging and the Immune System

Gretta Veronica Badillo-Pazmay
Carlo Fortunato
Laura Cianfruglia
Federica Novazzi
Pietro Giorgio Spezia
Luigi Rosa
Dolores Limongi
Carla Prezioso
Valeria D'Argenio
Olga Scudiero

Frontiers in Aging

461 views

Original Research

Published on 19 Dec 2025

CD38 promotes LPS-induced innate-like activation and proliferation of CD8+ T lymphocytes in aged mice

in Aging and the Immune System

Wendolaine Santiago-Cruz
Enrique Espinosa
Jocelyn C. Pérez-Lara
Héctor Romero-Ramírez
Priyadharshini Devarajan
Fabio García-García
Juan C. Rodríguez-Alba

Frontiers in Aging

doi 10.3389/fragi.2025.1701685

1,393 views

Review

Published on 18 Dec 2025

Methylation and algorithms in biological aging: a scoping review

in Aging and the Immune System

Alison Ziesel
Jennifer Reeves
Anastasia Mallidou
Lorelei Newton
Ryan E. Rhodes
Jie Zhang
Theone Paterson
Hosna Jabbari

Frontiers in Aging

doi 10.3389/fragi.2025.1682873

1,172 views

Original Research

Published on 11 Dec 2025

Age and liver transplantation: a key factor in clinical outcomes? single center study in Argentina

in Aging and the Immune System

Marco Santillán Pazmiño
Paula Constanza Arriola Benitez
Maria Florencia Fernandez
Silvina Yantorno
Valeria Descalzi
Franco Daniel Tarditti
María Lucia Novellis
Juan Cruz Fasolo
Martín Rumbo
Stefan Günther Tullius

Frontiers in Aging

doi 10.3389/fragi.2025.1729048

862 views

Review

Published on 21 Nov 2025

The gut–brain axis in Alzheimer’s disease: how gut microbiota modulate microglial function

in Aging and the Immune System

Huan Wang
Feifan Yang
Zhejianyi Gao
Zedong Cheng
Xicai Liang

Frontiers in Aging

doi 10.3389/fragi.2025.1704047

2,567 views
1 citation

Hypothesis and Theory

Published on 20 Nov 2025

Estimation of biological aging based on T-cell differentiation trajectories: emerging and future avenues

in Aging and the Immune System

Aarav M. Bhasin
Ishaan K. Marwaha
Lahiri S. Nooka

Frontiers in Aging

doi 10.3389/fragi.2025.1684051

1,471 views

Correction

Published on 18 Nov 2025

Correction: Influence of circadian rhythm on the determination of the IMMune Age indeX (IMMAX)

in Aging and the Immune System

Sina Trebing
Peter Bröde
Maren Claus
Carsten Watzl

Frontiers in Aging

doi 10.3389/fragi.2025.1743195

560 views

Review

Published on 12 Nov 2025

Advanced immunology in aging population: unveiling the complexities of vaccine responsiveness

in Aging and the Immune System

Yan Han
Yanhao Huang
Yuanyu Zhou
Wanke He
Gaomei Luo
Liu Yang
Yanbin Chen
Yiqi Zhu
Wei Jiang
Chanchan Xiao

Frontiers in Aging

doi 10.3389/fragi.2025.1682763

1,781 views

Original Research

Published on 07 Nov 2025

Influence of circadian rhythm on the determination of the IMMune Age indeX (IMMAX)

in Aging and the Immune System

Sina Trebing
Peter Bröde
Maren Claus
Carsten Watzl

Frontiers in Aging

doi 10.3389/fragi.2025.1716985

1,578 views

Review

Published on 20 Oct 2025

Acid sensing to inflammaging: mechanisms and therapeutic promise of GPR68 (OGR1) in aging-related diseases

in Aging and the Immune System

Jianlei Wei
Fengxin Cui
Zhihua Huang
Zeping Li
Zebin Mao
Pengxia Zhang

Frontiers in Aging

doi 10.3389/fragi.2025.1684450

4,006 views
2 citations

Mini Review

Published on 13 Oct 2025

Drug-mediated disruption of the aging gut microbiota and mucosal immune system

in Aging and the Immune System

Lia Totleben
Joel Thomas
Daniel Austin

Frontiers in Aging

doi 10.3389/fragi.2025.1603847

2,396 views

Review

Published on 01 Oct 2025

Natural autoantibodies and their functional therapeutic roles in intravenous immunoglobulin

in Aging and the Immune System

Maria Giovanna Danieli
Ilaria Claudi
Elena Buti
Luca Gammeri
Sebastiano Gangemi
Yehuda Julyus Shoenfeld

Frontiers in Aging

doi 10.3389/fragi.2025.1682457

3,504 views
1 citation

Perspective

Published on 30 Sep 2025

Inflammasome activation and accelerated immune aging in autoimmune disorders

in Aging and the Immune System

Rahul Mittal
Danay Saavedra
Mannat Mittal
Joana R. N. Lemos
Khemraj Hirani

Frontiers in Aging

doi 10.3389/fragi.2025.1688060

3,562 views
2 citations

Original Research

Published on 11 Sep 2025

Immune indicators as predictors of cancer-related fatigue: a risk prediction model in pan-cancer patients

in Aging and the Immune System

Guixin He
Ting Ge
Baohui Wang
Jianchun Yu
Wentao Li

Frontiers in Aging

doi 10.3389/fragi.2025.1666116

2,050 views

Original Research

Published on 09 Sep 2025

Reversal of perturbed DNA damage response and HIV latency by a histone methyltransferase inhibitor in virally suppressed individuals living with HIV

in Aging and the Immune System

Pragati Chavan
Sathi Koar
Rohini Bingewar
Anuja Sonawane
Jyoti Sawant
Pallavi Shidhaye
Amrita Rao
Rajani Bagul
Ujjwala Ghule
Sunita Kumbhar

Frontiers in Aging

doi 10.3389/fragi.2025.1658506

1,839 views

Original Research

Published on 29 Jul 2025

Beta-hydroxybutyrate (BHB) elicits concentration-dependent anti-inflammatory effects on microglial cells which are reversible by blocking its monocarboxylate (MCT) importer

in Aging and the Immune System

Chase Garcia
Ariana Banerjee
Claire Montgomery
Lauren Adcock
Izumi Maezawa
Jon Ramsey
Ana Cristina G. Grodzki
Kyoungmi Kim
Gino Cortopassi

Frontiers in Aging

doi 10.3389/fragi.2025.1628835

4,655 views
1 citation

Brief Research Report

Published on 20 May 2025

Hematopoietic stem cell size heterogeneity is not linked to changes in stem cell potential of aged HSCs

in Aging and the Immune System

Mehmet Saçma
Ali Hageb
Alex Zadro
Tanja Schuster
Mona Vogel
Karina Eiwen
Vadim Sakk
Hartmut Geiger

Frontiers in Aging

doi 10.3389/fragi.2025.1596565

3,948 views
2 citations

Systematic Review

Published on 10 Apr 2025

Global research trends in inflammaging from 2005 to 2024: a bibliometric analysis

in Aging and the Immune System

Beier Jiang
Yi-ni Dong
Yu Xiong
Chun-xia Jiang
Jun Ping
Qi Wu
Liu-jun Xu
Run-zhe Shu
Dan-dan Gao
Sheng-mei Zhu

Frontiers in Aging

doi 10.3389/fragi.2025.1554186

7,361 views
4 citations

107 articles

articles

Phenotypic and functional heterogeneity of naïve CD8+ T cells in human peripheral blood during aging

Age-associated B cells and double-negative B cells: two sides of the same coin? The answer depends on the context

Editorial: Cancer biology, immunotherapy and aging

Editorial: Immune senescence: a key driver of aging and age-related disorders

New insights into the association between cardiometabolic index with metabolic profile, nutritional status, and inflammaging in older adults

Global research landscape of telomere biology in infectious diseases: mechanistic links between host–pathogen interactions and immune ageing

The gut and circulating virome: emerging players in aging and longevity

CD38 promotes LPS-induced innate-like activation and proliferation of CD8+ T lymphocytes in aged mice

Methylation and algorithms in biological aging: a scoping review

Age and liver transplantation: a key factor in clinical outcomes? single center study in Argentina

The gut–brain axis in Alzheimer’s disease: how gut microbiota modulate microglial function

Estimation of biological aging based on T-cell differentiation trajectories: emerging and future avenues

Correction: Influence of circadian rhythm on the determination of the IMMune Age indeX (IMMAX)

Advanced immunology in aging population: unveiling the complexities of vaccine responsiveness

Influence of circadian rhythm on the determination of the IMMune Age indeX (IMMAX)

Acid sensing to inflammaging: mechanisms and therapeutic promise of GPR68 (OGR1) in aging-related diseases

Drug-mediated disruption of the aging gut microbiota and mucosal immune system

Natural autoantibodies and their functional therapeutic roles in intravenous immunoglobulin

Inflammasome activation and accelerated immune aging in autoimmune disorders

Immune indicators as predictors of cancer-related fatigue: a risk prediction model in pan-cancer patients

Reversal of perturbed DNA damage response and HIV latency by a histone methyltransferase inhibitor in virally suppressed individuals living with HIV

Beta-hydroxybutyrate (BHB) elicits concentration-dependent anti-inflammatory effects on microglial cells which are reversible by blocking its monocarboxylate (MCT) importer

Hematopoietic stem cell size heterogeneity is not linked to changes in stem cell potential of aged HSCs

Global research trends in inflammaging from 2005 to 2024: a bibliometric analysis