Frontiers in Aging | Genetics, Genomics and Epigenomics of Aging

Original Research

Accepted on 12 Dec 2025

Exploring Cognitive and Genetic Profiles in Healthy Adults: An Agglomerative Clustering Approach to APOE and PICALM Variants in Relation to Alzheimer's Disease

in Genetics, Genomics and Epigenomics of Aging

Adam Bednorz
Paulina Trybek
Minh Tuan Hoang
Dorota Religa

Frontiers in Aging

113 views

Review

Published on 04 Dec 2025

The intersection of TREX1, cGAS, STING and the DNA damage theory of aging

in Genetics, Genomics and Epigenomics of Aging

Kate M. Jones
Samuel D. Chauvin
Jonathan J. Miner

Frontiers in Aging

doi 10.3389/fragi.2025.1720372

694 views

Original Research

Accepted on 01 Dec 2025

RNA Transcripts in Salivary Extracellular Vesicle Cargo isolated from Aged Populations

in Genetics, Genomics and Epigenomics of Aging

Sicheng Wen
Chang Yu
Maxfield Kelsey
Mandy Pereira
Hannah Alaimo
Em Teixeira
Jenna Pracht
Lori A. Daiello
Jonathan Drake
John Sedivy

Frontiers in Aging

173 views

Brief Research Report

Published on 01 Dec 2025

Epigenetic age acceleration and neurotrophin signaling pathways in cancer-related cognitive impairment: a longitudinal, prospective cohort study

in Genetics, Genomics and Epigenomics of Aging

Michael Sayer
Ding Quan Ng
Julia Trudeau
Raymond J. Chan
Munjal M. Acharya
Kord Kober
Alexandre Chan

Frontiers in Aging

doi 10.3389/fragi.2025.1667638

965 views

Original Research

Accepted on 21 Nov 2025

Emerging PFAS Contaminants PFNA and PFSA Amplify Epigenetic Aging: Sex-and Age-Stratified Risks in an Aging Population

in Genetics, Genomics and Epigenomics of Aging

Ya-Qian Xu
Chongyu Ding
Hui Zhang
Yulu Gong
Darong Hao
Xuetong Zhao
Kai Li

Frontiers in Aging

325 views

Editorial

Published on 14 Nov 2025

Editorial: Aging epigenome and longevity

in Genetics, Genomics and Epigenomics of Aging

Sandeep Kumar Singh
Burkhard Poeggeler

Frontiers in Aging

doi 10.3389/fragi.2025.1739913

613 views

Original Research

Published on 19 Sep 2025

Aging-dependent skin microbiome alterations across body sites in a United Kingdom cohort

in Genetics, Genomics and Epigenomics of Aging

Mary Hannah Swaney
Duncan J. Newman
Junhong Mao
Anthony C. Hilton
Tony Worthington
Min Li

Frontiers in Aging

doi 10.3389/fragi.2025.1644012

2,637 views

Original Research

Published on 12 Sep 2025

Chromogranin a gene variants influence survival at old age through pleiotropic effects on multiple age-related traits

in Genetics, Genomics and Epigenomics of Aging

Paolina Crocco
Rossella La Grotta
Francesco De Rango
Giuseppe Passarino
Serena Dato
Giuseppina Rose

Frontiers in Aging

doi 10.3389/fragi.2025.1625070

1,700 views

Opinion

Published on 18 Aug 2025

The human biological clock and aging—a comprehensive approach integrating reductionism, holism, and geromedicine for proactive healthspan strategies

in Genetics, Genomics and Epigenomics of Aging

Teow J. Phua

Frontiers in Aging

doi 10.3389/fragi.2025.1658952

3,299 views
1 citation

Editorial

Published on 14 Aug 2025

Editorial: Interaction between genes and the environment in skin aging

in Genetics, Genomics and Epigenomics of Aging

Xiaolei Ding
Sigrid Le Clerc

Frontiers in Aging

doi 10.3389/fragi.2025.1671721

1,536 views
1 citation

Original Research

Published on 23 Jul 2025

Identification of gene–sun exposure interactions of GWAS-identified variants in perceived facial aging progression

in Genetics, Genomics and Epigenomics of Aging

Ludivine Obry
Raissa Medina-Santos
Myriam Rahmouni
Josselin Noirel
Toufik Labib
Pilar Galan
Jean-Louis Spadoni
Gaëlle Gendronneau
Randa Jdid
Sandra Courrèges

Frontiers in Aging

doi 10.3389/fragi.2025.1519799

2,102 views

Mini Review

Published on 13 May 2025

miRNA mediated mitochondrial function and gene regulation associated with Alzheimer’s disease

in Genetics, Genomics and Epigenomics of Aging

Kumudu Subasinghe
Robert Barber
Nicole Phillips

Frontiers in Aging

doi 10.3389/fragi.2025.1582812

2,286 views
1 citation

Editorial

Published on 12 May 2025

Editorial: Mechanistic theories of aging

in Genetics, Genomics and Epigenomics of Aging

John Tower

Frontiers in Aging

doi 10.3389/fragi.2025.1617783

1,642 views

Original Research

Published on 28 Feb 2025

Multiplexing and massive parallel sequencing of targeted DNA methylation to predict chronological age

in Genetics, Genomics and Epigenomics of Aging

Bowen Zhu
Dean Li
Guojing Han
Xue Yao
Hongqin Gu
Tao Liu
Linghua Liu
Jie Dai
Isabella Zhaotong Liu
Yanlin Liang

Frontiers in Aging

doi 10.3389/fragi.2025.1467639

2,435 views

Original Research

Published on 23 Jan 2025

Precise and interpretable neural networks reveal epigenetic signatures of aging across youth in health and disease

in Genetics, Genomics and Epigenomics of Aging

David Martínez-Enguita
Thomas Hillerton
Julia Åkesson
Daniel Kling
Maria Lerm
Mika Gustafsson

Frontiers in Aging

doi 10.3389/fragi.2024.1526146

4,494 views
1 citation

Review

Published on 06 Jan 2025

DNA methylation, histone acetylation in the regulation of memory and its modulation during aging

in Genetics, Genomics and Epigenomics of Aging

Padmanabh Singh
Vijay Paramanik

Frontiers in Aging

doi 10.3389/fragi.2024.1480932

5,571 views
9 citations

Review

Published on 16 Dec 2024

New insights into methods to measure biological age: a literature review

in Genetics, Genomics and Epigenomics of Aging

Aanchal Mathur
Sebastien Taurin
Sfoug Alshammary

Frontiers in Aging

doi 10.3389/fragi.2024.1395649

11,382 views
11 citations

Review

Published on 13 Dec 2024

Critical review of aging clocks and factors that may influence the pace of aging

in Genetics, Genomics and Epigenomics of Aging

Mildred Min
Caitlin Egli
Ajay S. Dulai
Raja K. Sivamani

Frontiers in Aging

doi 10.3389/fragi.2024.1487260

13,305 views
18 citations

Original Research

Published on 02 Dec 2024

Assessing the utility of epigenetic clocks for health prediction in South Korean

in Genetics, Genomics and Epigenomics of Aging

Dong Jun Kim
Joon Ho Kang
Ji-Woong Kim
Sun bin Kim
Young Kee Lee
Myeong Jae Cheon
Byung-Chul Lee

Frontiers in Aging

doi 10.3389/fragi.2024.1493406

4,176 views
4 citations

Mini Review

Published on 13 Nov 2024

The role of anti-aging approaches in managing hypogonadism in sedentary older males

in Genetics, Genomics and Epigenomics of Aging

Khaled A. Abdel-Sater

Frontiers in Aging

doi 10.3389/fragi.2024.1514438

6,112 views

Original Research

Published on 01 Nov 2024

Telomere length and cognitive changes in 7,877 older UK adults of European ancestry

in Genetics, Genomics and Epigenomics of Aging

Amy Packer
Leena Habiballa
Esteban Tato-Barcia
Gerome Breen
Helen Brooker
Anne Corbett
Ryan Arathimos
Clive Ballard
Adam Hampshire
Abbie Palmer

Frontiers in Aging

doi 10.3389/fragi.2024.1480326

2,643 views

Mini Review

Published on 09 Oct 2024

G-quadruplex DNA and RNA in cellular senescence

in Genetics, Genomics and Epigenomics of Aging

Rocio Diaz Escarcega
Paul Marshall
Andrey S. Tsvetkov

Frontiers in Aging

doi 10.3389/fragi.2024.1491389

5,554 views
2 citations

Brief Research Report

Published on 01 Oct 2024

CheekAge, a next-generation epigenetic buccal clock, is predictive of mortality in human blood

in Genetics, Genomics and Epigenomics of Aging

Maxim N. Shokhirev
Daniel J. Kramer
Janie Corley
Simon R. Cox
Trinna L. Cuellar
Adiv A. Johnson

Frontiers in Aging

doi 10.3389/fragi.2024.1460360

14,922 views
5 citations

Original Research

Published on 18 Sep 2024

Gene co-expression networks reveal sex-biased differences in musculoskeletal ageing

in Genetics, Genomics and Epigenomics of Aging

Samael Olascoaga
Hugo Tovar
Jesús Espinal-Enríquez

Frontiers in Aging

doi 10.3389/fragi.2024.1469479

2,414 views

64 articles

articles

Exploring Cognitive and Genetic Profiles in Healthy Adults: An Agglomerative Clustering Approach to APOE and PICALM Variants in Relation to Alzheimer's Disease

The intersection of TREX1, cGAS, STING and the DNA damage theory of aging

RNA Transcripts in Salivary Extracellular Vesicle Cargo isolated from Aged Populations

Epigenetic age acceleration and neurotrophin signaling pathways in cancer-related cognitive impairment: a longitudinal, prospective cohort study

Emerging PFAS Contaminants PFNA and PFSA Amplify Epigenetic Aging: Sex-and Age-Stratified Risks in an Aging Population

Editorial: Aging epigenome and longevity

Aging-dependent skin microbiome alterations across body sites in a United Kingdom cohort

Chromogranin a gene variants influence survival at old age through pleiotropic effects on multiple age-related traits

The human biological clock and aging—a comprehensive approach integrating reductionism, holism, and geromedicine for proactive healthspan strategies

Editorial: Interaction between genes and the environment in skin aging

Identification of gene–sun exposure interactions of GWAS-identified variants in perceived facial aging progression

miRNA mediated mitochondrial function and gene regulation associated with Alzheimer’s disease

Editorial: Mechanistic theories of aging

Multiplexing and massive parallel sequencing of targeted DNA methylation to predict chronological age

Precise and interpretable neural networks reveal epigenetic signatures of aging across youth in health and disease

DNA methylation, histone acetylation in the regulation of memory and its modulation during aging

New insights into methods to measure biological age: a literature review

Critical review of aging clocks and factors that may influence the pace of aging

Assessing the utility of epigenetic clocks for health prediction in South Korean

The role of anti-aging approaches in managing hypogonadism in sedentary older males

Telomere length and cognitive changes in 7,877 older UK adults of European ancestry

G-quadruplex DNA and RNA in cellular senescence

CheekAge, a next-generation epigenetic buccal clock, is predictive of mortality in human blood

Gene co-expression networks reveal sex-biased differences in musculoskeletal ageing