Frontiers in Aging | Musculoskeletal Aging

Brief Research Report

Published on 18 Feb 2026

Obesity and low lean mass are associated with dysregulated IGFBP-3, inflammatory biomarkers, and physical impairment in older adult women with frailty

in Musculoskeletal Aging

Alan L. Fernandes
Rosa M. R. Pereira
Valeria F. Caparbo
Camila S. Figueredo
Caroline F. Gomes
Eduardo F. B. Neto
Diogo S. Domiciano

Frontiers in Aging

doi 10.3389/fragi.2026.1765052

148 views

Original Research

Accepted on 17 Feb 2026

Evaluating the Performance of Large Language Models in Sarcopenia-Related Patient Queries: A Foundational Assessment for Patient-Centered Validation

in Musculoskeletal Aging

Tao HUANG
Ben Kirk
Jacqueline CLOSE
Jae-Young Lim
Gustavo Duque
Peter Ebeling
Minghui Yang
Maoyi Tian
Chun Sing CHUI
Chaoran LIU

Frontiers in Aging

Original Research

Accepted on 17 Feb 2026

A New Physical Measure for Sarcopenia assessment: Development Validation and Physiological Evaluation

in Musculoskeletal Aging

Blanca Pedauyé Rueda
José Luis Maté Muñoz
Juan Hernández Lougedo
Iñigo Aparicio García
Sara Cerrolaza-Tudanca
Mauel Rozalén Bustín
Inmaculida Rodríguez Moreno
Pablo García Fernández

Frontiers in Aging

Original Research

Accepted on 16 Feb 2026

Elevated Circulating GDF11 and Its Role in Age-Related Sarcopenia: Insights from Clinical, Transcriptomic, and In Vitro Analyses

in Musculoskeletal Aging

Rui Rui Chen
Xin Dai
Hong Wang
Ting Zhang
Zhao Zhang
Yaoxia Liu
Fan Zhen

Frontiers in Aging

Original Research

Accepted on 16 Feb 2026

Development and Validation of a Machine Learning-Based Risk Prediction Model for Sarcopenia in Community Hospital Patients: A Retrospective Cohort Study

in Musculoskeletal Aging

Xue Zhao
Wang Yao
Jiawei Shen
Xinyu Tang
Jue Zheng
Chang Guo
Sun Ye
Miqiong Li
Chao Wang
Peihao Yin

Frontiers in Aging

Review

Accepted on 16 Feb 2026

Wnt16: a new potential therapeutic target for osteoporotic non-vertebral fracture treatment

in Musculoskeletal Aging

Tian Peng Chen
Gongtao Jiang

Frontiers in Aging

Original Research

Accepted on 16 Feb 2026

Age-related compensation in motor control: Task-dependent trade-offs between efficiency and equilibrium

in Musculoskeletal Aging

Robin MATHIEU
Florian Chambellant
Denis Barbusse
Elizabeth Thomas
Charalambos Papaxanthis
Pauline Hilt
Patrick Manckoundia
France Mourey
Jeremie Gaveau

Frontiers in Aging

Review

Accepted on 13 Feb 2026

Targeting Innate Immunity to Modulate Bone Metabolism: A Novel Strategy for Osteoporosis Treatment

in Musculoskeletal Aging

Wenjie Kou Kou
Xiaomin Lu Lu
Zhe Zhang Zhang
Kaiwen Liu Liu
Zhihuan Liu Liu
Bin Jiang Jiang
Hongping Wang Wang
Jishu Li Li
Hu Lu Lu
Chenglong Guo Guo

Frontiers in Aging

Brief Research Report

Published on 12 Feb 2026

Impact of comorbidities in patients with erosive hand osteoarthritis (EHOA), a monocentric study

in Musculoskeletal Aging

S. Bindoli
G. Cozzi
C. Benvoluti
M. Lorenzin
S. Vio
P. Sfriso
M. Favero
R. Ramonda

Frontiers in Aging

doi 10.3389/fragi.2026.1748066

314 views

Original Research

Published on 11 Feb 2026

Does time spent upright moderate the influence of a weighted vest on change in bone mineral density during weight loss among older adults? A secondary analysis of the INVEST in bone health randomized controlled trial

in Musculoskeletal Aging

Jason Fanning
Daniel P. Beavers
Shirley M. Bluethmann
S. Delanie Lynch
Ashley A. Weaver
Cassidy Guida
Kristen M. Beavers

Frontiers in Aging

doi 10.3389/fragi.2026.1729001

434 views

Original Research

Published on 04 Feb 2026

Tensiomyography-derived contractile parameters in sarcopenic and non-sarcopenic older adults

in Musculoskeletal Aging

Katarina Pus
Miloš Kalc
Boštjan Šimunič

Frontiers in Aging

doi 10.3389/fragi.2026.1719152

3,001 views

Original Research

Published on 07 Jan 2026

Muscle quality correlates with hearing thresholds: a cross-sectional analysis

in Musculoskeletal Aging

Young-Jee Jeon
Ji Ho Lee
Byung Chul Kang
Joong Keun Kwon

Frontiers in Aging

doi 10.3389/fragi.2025.1706350

826 views

Original Research

Published on 10 Dec 2025

Impact of multicomponent home-based exercise on fear of falling in older people with a history of falls: insights from the GAITCARE project

in Musculoskeletal Aging

Elisabet Huertas-Hoyas
Marta Neira Álvarez
Agustín Curiel-Regueros
Luisa Ruiz-Ruiz
Rafael García-Molina
Cristina Alonso Bouzón
Eva Rincon-Herrera
Sara García De Villa
Antonio R. Jiménez-Ruiz

Frontiers in Aging

doi 10.3389/fragi.2025.1698917

874 views

Brief Research Report

Published on 27 Nov 2025

Bone mineral density and turnover response to GLP-1 receptor agonists in older adults with overweight/obesity and prediabetes/type 2 diabetes: a 20-week pilot trial post hoc analysis

in Musculoskeletal Aging

Lauren Dinkla
Kristen M. Beavers
Ronna Robbins
Dela Akpalu
Sarah J. Wherry
Gary Miller
Daniel P. Beavers
Sara Espinoza
Jonathan Trejo
Allison Stepanenko

Frontiers in Aging

doi 10.3389/fragi.2025.1691007

2,749 views

Original Research

Published on 26 Nov 2025

Lived experiences and informed behavior change among premenopausal women in a group exercise trial: a qualitative inquiry

in Musculoskeletal Aging

Jaclyn Inel Hadfield
Ryan Hulteen
Jenna Parsons
Heather Allaway

Frontiers in Aging

doi 10.3389/fragi.2025.1712679

1,045 views

Original Research

Published on 20 Nov 2025

Muscle quality responses to short-term resistance training volume in older adults: an exploratory clinical trial

in Musculoskeletal Aging

Kevan S. Knowles
Logan A. Banks
Vanessa C. Cabrera
Wyatt Wilkinson
Adrian J. Pantoja
Isabella G. Thomas
Emily J. Parsowith
Jonathan P. Beausejour
Grant Norte
Jeffrey R. Stout

Frontiers in Aging

doi 10.3389/fragi.2025.1670709

2,112 views

Original Research

Published on 19 Nov 2025

The association between anserine bursa pain and fall susceptibility: a prospective analysis of the osteoarthritis initiative

in Musculoskeletal Aging

Fugui Wang
Jianhua Xiao
Zhi Song
Chao Zhang
Zhengyuan Zhu

Frontiers in Aging

doi 10.3389/fragi.2025.1666627

880 views

Brief Research Report

Published on 19 Nov 2025

Effect of maximal mental effort during elastic band training on neuromuscular adaptations in older women

in Musculoskeletal Aging

Lacey Harper
Kayla Anderson
William Reed
Kaden Buford
Anna Acosta
Jacob Grazer
Robert Buresh
Tim Martin
Garrett Hester

Frontiers in Aging

doi 10.3389/fragi.2025.1662126

1,261 views

Perspective

Published on 24 Oct 2025

Moving beyond the scale: musculoskeletal risks, evidence gaps and emerging combination strategies to optimize the quality of weight loss pharmacotherapy in older adults

in Musculoskeletal Aging

Kieran F. Reid
Shalender Bhasin

Frontiers in Aging

doi 10.3389/fragi.2025.1640030

1,818 views

Original Research

Published on 23 Oct 2025

Injuries among middle aged and older adult patients presenting to the emergency department: a retrospective cohort study

in Musculoskeletal Aging

Abdullah M. Basnawi
Syeda Nafeesa Hashim
Sariya Khan
Husna Irfan Thalib
Ayesha Mirza Ayub
Sana Hashim
Fatimah Shakeel
Jumana Timraz
Fathma Islam

Frontiers in Aging

doi 10.3389/fragi.2025.1652588

1,197 views

Original Research

Published on 22 Oct 2025

Comparative effectiveness of lower body positive pressure and traditional treadmill training on adults with mild balance impairment

in Musculoskeletal Aging

Hina Shafi
Waqar Ahmed Awan
Sharon Olsen
Furqan Ahmed Siddiqi
Usman Rashid
Imran Khan Niazi

Frontiers in Aging

doi 10.3389/fragi.2025.1645026

1,788 views

Original Research

Published on 18 Aug 2025

Risk factors and predictors of contralateral hip fracture after surgical treatment in elderly patients

in Musculoskeletal Aging

Huan Yang
Yusong Yuan
Ruidong Ge
Lei Shi
Fangda Si
Ying Chen

Frontiers in Aging

doi 10.3389/fragi.2025.1633184

1,859 views

Correction

Published on 31 Jul 2025

Correction: Age- and sex-related development of osteosarcopenia in the aging Octodon degus rodent model

in Musculoskeletal Aging

Pablo Gallo-Soljancic
Maria Egle De Stefano
Ana-Maria Lucas-Ochoa
Consuelo Sánchez-Rodrigo
Lorena Cuenca-Bermejo
Ana-María González-Cuello
Emiliano Fernández-Villalba
Maria-Trinidad Herrero

Frontiers in Aging

doi 10.3389/fragi.2025.1669031

1,640 views

Original Research

Published on 24 Jul 2025

Age-related gait adaptations: analysis of temporal gait parameters and variability, and muscle activation across flat vs. uneven surfaces in young, middle-aged, and older adults

in Musculoskeletal Aging

Thomas B. Inns
Ilaria Pina
Lewis James Macgregor
Paul A. Dudchenko
Rachel A. Crockett
Angus Murray Hunter

Frontiers in Aging

doi 10.3389/fragi.2025.1573778

3,493 views

62 articles

articles

Obesity and low lean mass are associated with dysregulated IGFBP-3, inflammatory biomarkers, and physical impairment in older adult women with frailty

Evaluating the Performance of Large Language Models in Sarcopenia-Related Patient Queries: A Foundational Assessment for Patient-Centered Validation

A New Physical Measure for Sarcopenia assessment: Development Validation and Physiological Evaluation

Elevated Circulating GDF11 and Its Role in Age-Related Sarcopenia: Insights from Clinical, Transcriptomic, and In Vitro Analyses

Development and Validation of a Machine Learning-Based Risk Prediction Model for Sarcopenia in Community Hospital Patients: A Retrospective Cohort Study

Wnt16: a new potential therapeutic target for osteoporotic non-vertebral fracture treatment

Age-related compensation in motor control: Task-dependent trade-offs between efficiency and equilibrium

Targeting Innate Immunity to Modulate Bone Metabolism: A Novel Strategy for Osteoporosis Treatment

Impact of comorbidities in patients with erosive hand osteoarthritis (EHOA), a monocentric study

Does time spent upright moderate the influence of a weighted vest on change in bone mineral density during weight loss among older adults? A secondary analysis of the INVEST in bone health randomized controlled trial

Tensiomyography-derived contractile parameters in sarcopenic and non-sarcopenic older adults

Muscle quality correlates with hearing thresholds: a cross-sectional analysis

Impact of multicomponent home-based exercise on fear of falling in older people with a history of falls: insights from the GAITCARE project

Bone mineral density and turnover response to GLP-1 receptor agonists in older adults with overweight/obesity and prediabetes/type 2 diabetes: a 20-week pilot trial post hoc analysis

Lived experiences and informed behavior change among premenopausal women in a group exercise trial: a qualitative inquiry

Muscle quality responses to short-term resistance training volume in older adults: an exploratory clinical trial

The association between anserine bursa pain and fall susceptibility: a prospective analysis of the osteoarthritis initiative

Effect of maximal mental effort during elastic band training on neuromuscular adaptations in older women

Moving beyond the scale: musculoskeletal risks, evidence gaps and emerging combination strategies to optimize the quality of weight loss pharmacotherapy in older adults

Injuries among middle aged and older adult patients presenting to the emergency department: a retrospective cohort study

Comparative effectiveness of lower body positive pressure and traditional treadmill training on adults with mild balance impairment

Risk factors and predictors of contralateral hip fracture after surgical treatment in elderly patients

Correction: Age- and sex-related development of osteosarcopenia in the aging Octodon degus rodent model

Age-related gait adaptations: analysis of temporal gait parameters and variability, and muscle activation across flat vs. uneven surfaces in young, middle-aged, and older adults