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ORIGINAL RESEARCH article

Front. Artif. Intell.

Sec. Machine Learning and Artificial Intelligence

This article is part of the Research TopicApplications and Advances of Artificial Intelligence in Medical Image Analysis: PET, SPECT/ CT, MRI, and Pathology ImagingView all 12 articles

Explainable AI-Driven MRI-Based Brain Tumor Classification: A Novel Deep Learning Approach

Provisionally accepted
Parvathi  RParvathi R*VINAYAKA  SRINIVAS RVINAYAKA SRINIVAS R
  • Vellore Institute of Technology (VIT), Chennai, India

The final, formatted version of the article will be published soon.

Brain tumors are among the most aggressive forms of cancer, requiring precise diagnosis and treatment planning to improve patient outcomes. This study aims to develop an efficient deep learning-based framework for the classification of brain tumors using MRI data. The methodology employs Convolutional Neural Networks (CNNs) to accurately classify tumors into four categories: normal, glioma, pituitary, and meningioma. Key preprocessing techniques, including noise reduction, resizing, and data augmentation, were applied to enhance the robustness of the model. Advanced architectures such as DenseNet50, VGG19, and other transfer learning models, along with CNN variants, were trained and evaluated for their performance. Explainable AI (XAI) techniques, includ-ing Grad-CAM, LIME, and feature map visualizations, played a crucial role in providing better visualizations of the model's decision-making process and iden-tifying areas of improvement during model training and to establish a better model. The best-performing model, a 4-conv-1-dense-1-dropout CNN, achieved a classification accuracy of 95.86%, outperforming deeper architectures and transfer learning approaches. The findings underscore the potential of deep learning models for reliable and efficient brain tumor classification. This work concludes with recommendations for real-time deployment in clinical settings and explores future integration with Large Language Models (LLMs) to generate detailed diagnostic reports.

Keywords: Brain tumor classification, Convolutional neural networks (CNNs), Data augmentation, deep learning, Explainable AI (XAI), Feature visualization, medical imaging, MRI

Received: 06 Sep 2025; Accepted: 30 Nov 2025.

Copyright: © 2025 R and SRINIVAS R. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence: Parvathi R

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