ORIGINAL RESEARCH article
Front. Behav. Neurosci.
Sec. Individual and Social Behaviors
Volume 19 - 2025 | doi: 10.3389/fnbeh.2025.1561615
Comparison of Ziprasidone and Olanzapine on Cognitive Function in Patients with Schizophrenia at Different Stages: A Prospective Study in Yangzhou, China
Provisionally accepted
- Jinhu People’s Hospital, Jinhu, China
Select one of your emails
You have multiple emails registered with Frontiers:
Notify me on publication
Please enter your email address:
If you already have an account, please login
You don't have a Frontiers account ? You can register here
Objective: To compare the effects of ziprasidone and olanzapine on cognitive function in patients with first-episode schizophrenia and chronic schizophrenia at different stages. Methods: Cognitive function tests were performed on chronic schizophrenic patients who took olanzapine for a long time, first-episode drug-free schizophrenic patients, and healthy controls. Results: There were significant differences in the digit span test, Stroop color and word test, auditory verbal learning test N2, N3, N4, trail-making test, verbal fluency test, and clock drawing test between first-episode drug-free schizophrenic patients and healthy controls (p<0.05). Compared with patients with chronic schizophrenia, there were significant differences in the digit span test, Stroop color and word test B, auditory verbal learning test, trail making test B, and clock drawing test in patients with first-episode schizophrenia after 4 weeks of olanzapine treatment (p<0.05). Compared with patients with chronic schizophrenia after 4 weeks of Ziprasidone treatment, patients with first-episode schizophrenia had significant differences in the digit span test, Stroop color, and word test, auditory verbal learning test N3, and clock drawing test after 4 weeks of olanzapine treatment (p<0.05). Compared with patients with chronic schizophrenia who were treated with Ziprasidone for 12 weeks, there were significant differences in Stroop color and word test A, auditory verbal learning test N3, and clock drawing test in patients with first-episode schizophrenia after 4 weeks of olanzapine treatment (p<0.05). Conclusion: Patients with schizophrenia have cognitive dysfunction in the early stage of onset. The combination of ziprasidone and olanzapine can effectively improve cognitive dysfunction and promote the recovery of social functions of patients.
Keywords: Schizophrenia, antipsychotic drugs, drug combination, Cognitive Function, Ziprasidone
Received: 16 Jan 2025; Accepted: 15 Sep 2025.
Copyright: © 2025 Yao, Liu, Xiao, Zhang, Qi, Ge, Han and Wang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Hua Han, 19852555868@163.com
Xiuling Wang, wxl0809@126.com
Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.