BRIEF RESEARCH REPORT article

Front. Behav. Neurosci.

Sec. Pathological Conditions

Volume 19 - 2025 | doi: 10.3389/fnbeh.2025.1614730

This article is part of the Research TopicPsychopathological and behavioral trajectories in transitional-age youth: Innovative approaches and paradigmsView all 7 articles

Multi-Domain Destructuring in the Early Phases of Psychosis: A multicentric Phenomenological and Psychometric case-control study

Provisionally accepted
Ottone  Baccaredda BoyOttone Baccaredda Boy1,2*Giuseppe Pierpaolo  MerolaGiuseppe Pierpaolo Merola1Andrea  PattiAndrea Patti3,4Bernardo  BozzaBernardo Bozza1Dario  FlaccomioDario Flaccomio1Marco  FaldiMarco Faldi1Giulia  PittGiulia Pitt1Luca  PapiniLuca Papini1Vincenzo  PecoraroVincenzo Pecoraro1Ilaria  NoscheseIlaria Noschese1,5*Elisa  Di MatteoElisa Di Matteo1Dario  BrugnoloDario Brugnolo1Camilla  RicciCamilla Ricci1,6Andrea  BalleriniAndrea Ballerini1Francesco  MauceriFrancesco Mauceri1,5Simone  TavanoSimone Tavano1,5Giulio  PeroniGiulio Peroni1,5Sara  CiabattiniSara Ciabattini1,5Sara  GoriSara Gori5Tiziana  PisanoTiziana Pisano5Francesco  De CesarisFrancesco De Cesaris1David  CohenDavid Cohen7Valdo  RiccaValdo Ricca1
  • 1University of Florence, Florence, Italy
  • 2Hospital of Prato, Prato, Italy
  • 3Eating Disorder Clinic 'Residenza Gruber', Bologna, Emilia-Romagna, Italy
  • 4Santagostino Medical Center, Bologna, Italy
  • 5Azienda Ospedaliera Universitaria Meyer IRCCS - Firenze, Florence, Tuscany, Italy
  • 6University of Bologna, Bologna, Emilia-Romagna, Italy
  • 7Child and Adolescent Psychiatry Unit, Institute IDEAL, APHP.Sorbonne Univesity, Hôpital Pitié-Salpêtrière, Paris, France

The final, formatted version of the article will be published soon.

Introduction: the study aims to evaluate symptomatic differences through psychometric tools comparing patients in the early stages of psychotic development with those exhibiting a more established symptomatology. Our hypothesis was that the early phase in adolescent patients is accompanied by quantitatively and qualitatively distinct symptomatology compared to adults.Methods: we assessed 116 participants -consisting of 14 to 65 years old patients with psychotic or mood symptoms -using psychometric tools and a clinical interview. The tools explored psychotic, depressive and anxiety dimensions, to provide a multifaceted assessment of the recruited individuals and help at categorizing them into diagnostic subclasses.Results: we compared patients with psychotic symptoms (early-onset and lifetime) to patients with mood disorders (unipolar depression or bipolar disorder without psychotic symptoms). Psychotic symptoms intensity was significantly higher in the early-onset group compared to the lifetime group and was markedly greater than in the two other groups. It was also observed that the intensity of anxiety and depressive symptoms in the psychosis group were significantly higher in the early-onset subgroup.Conclusions: our findings suggest that the clinical presentation of early-onset patients, typically striking in its symptomatology, is reflected by elevated scores on scales not routinely used for psychotic symptoms. This may be attributed to the pervasive destructuring of personality and reality characteristic of early psychotic experiences.

Keywords: salience, psychosis, FEP, Anxiety, Depression, Cannabis

Received: 19 Apr 2025; Accepted: 30 Jun 2025.

Copyright: © 2025 Baccaredda Boy, Merola, Patti, Bozza, Flaccomio, Faldi, Pitt, Papini, Pecoraro, Noschese, Di Matteo, Brugnolo, Ricci, Ballerini, Mauceri, Tavano, Peroni, Ciabattini, Gori, Pisano, De Cesaris, Cohen and Ricca. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence:
Ottone Baccaredda Boy, University of Florence, Florence, Italy
Ilaria Noschese, University of Florence, Florence, Italy

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