REVIEW article
Front. Bioeng. Biotechnol.
Sec. Tissue Engineering and Regenerative Medicine
Volume 13 - 2025 | doi: 10.3389/fbioe.2025.1446537
This article is part of the Research TopicInsights into the manufacturing, storage and transport of therapies for regenerative medicine: Challenges and Changing perspectivesView all 5 articles
Natural bioactive compounds modified with mesenchymal stem cells: New hope for regenerative medicine
Provisionally accepted
- 1Third Affiliated Hospital of Zunyi Medical University (The First People’s Hospital of Zunyi), China, China
- 2Key Laboratory of Basic Pharmacology of Ministry of Education and Joint International Research Lab of Ethnomedicine of Ministry of Education, Zunyi Medical University, Zunyi, Guizhou Province, China
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Mesenchymal stem cells (MSCs) have the potential to differentiate into various cell types, providing important sources of cells for the development of regenerative medicine. Although MSCs have various advantages, there are also various problems, such as the low survival rate of transplanted cells and poor migration and homing; therefore, determining how to reform MSCs to improve their utilization is particularly important. Although many natural bioactive compounds have shown great potential for improving MSCs, many mechanisms and pathways are involved; however, in the final analysis, natural bioactive compounds promoted MSC proliferation, migration and homing and promoted differentiation and antiaging. This article reviews the regulatory effects of natural bioactive compounds on MSCs to provide new ideas for the therapeutic effects of modified MSCs on diseases.
Keywords: Mesenchymal Stem Cells, Natural bioactive compounds, resveratrol, Icariin, Ginkgo biloba extract, tanshinone IIA, Astragaloside IV, Curcumin
Received: 10 Jun 2024; Accepted: 25 Apr 2025.
Copyright: © 2025 Wu, Ge, Huang, Zhang, Huang, Huang and Luo. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Juan Huang, Key Laboratory of Basic Pharmacology of Ministry of Education and Joint International Research Lab of Ethnomedicine of Ministry of Education, Zunyi Medical University, Zunyi, Guizhou Province, China
Nanqu Huang, Third Affiliated Hospital of Zunyi Medical University (The First People’s Hospital of Zunyi), China, China
Yong Luo, Third Affiliated Hospital of Zunyi Medical University (The First People’s Hospital of Zunyi), China, China
Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.