REVIEW article
Front. Bioeng. Biotechnol.
Sec. Tissue Engineering and Regenerative Medicine
Volume 13 - 2025 | doi: 10.3389/fbioe.2025.1502881
A recent review on the application of piezoelectric-based polymeric scaffolds in cardiac and neural tissue engineering
Provisionally accepted
Yasmin Noorafkan1,2
Bahareh Darzi2,3
Erfan Dorkhani2,3Shayan Hosseini1Zeinab Salehi3*
Seyed Hossein Ahmadi Tafti2*
Seyed Mohsen Ahmadi Tafti4- 1Department of Polymer engineering, Faculty of Chemical Engineering, Isfahan University of Technology, Isfahan, Iran, Isfahan, Iran
- 2Research Center for Advanced Technologies in Cardiovascular Medicine, Cardiovascular Diseases, Research Institute, Tehran University of Medical Sciences, Tehran, Iran, Tehran, Alborz, Iran
- 3School of Chemical Engineering, College of Engineering, University of Tehran, Tehran, Iran
- 4Research Center for Advanced Technologies in Colorectal Medicine, Imam Khomeini hospital, Tehran, Iran, Tehran, Alborz, Iran
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The application of innovative materials in tissue engineering is increasingly gaining attraction to modulate cell functionalities and regeneration efficacy. The regeneration process mainly demands electrical and electromechanical stimuli to provide an environment similar to the native tissue extracellular matrix (ECM), considering the significant challenges in tissue engineering approaches. Remarkably, treating cardiovascular or nervous system-related diseases and injuries has been challenging due to its limited potential in self-regeneration. Tissue engineering is one of the principal approaches to repairing damaged cells by providing a desirable 3D environment for cell growth, proliferation, and differentiation using polymerbased structures with unique designs. In other words, the transplantation of stem cells with the help of polymeric scaffolds, bridging the nerve gap using bioengineered channels known as neural guidance conduits (NGCs), and driving cardiomyocytes toward the desired phenotype are significant applications of regenerative medicine in treating central and peripheral nervous system injuries and cardiovascular failures. Regarding their ability to generate electrical stimuli, which promote cellular activities, piezoelectric materials are one of the choices considered for cardiac and neural tissue reconstruction thanks to their ability to transmit electrical signals among cells by mechanoelectrical transduction. Thus, in this study, we have prepared a comprehensive review of several piezoelectric-based scaffolds recently applied in the neural and cardiac tissue engineering field.
Keywords: Piezoelectric scaffolds, Neural tissue engineering, cardiac tissue engineering, electro-responsive biomaterials, Mechanical excitation
Received: 27 Sep 2024; Accepted: 14 May 2025.
Copyright: © 2025 Noorafkan, Darzi, Dorkhani, Hosseini, Salehi, Ahmadi Tafti and Ahmadi Tafti. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Zeinab Salehi, School of Chemical Engineering, College of Engineering, University of Tehran, Tehran, Iran
Seyed Hossein Ahmadi Tafti, Research Center for Advanced Technologies in Cardiovascular Medicine, Cardiovascular Diseases, Research Institute, Tehran University of Medical Sciences, Tehran, Iran, Tehran, Alborz, Iran
Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.