ORIGINAL RESEARCH article
Front. Bioeng. Biotechnol.
Sec. Biomechanics
Volume 13 - 2025 | doi: 10.3389/fbioe.2025.1539256
This article is part of the Research TopicDiagnostic and Predictive Roles of Computational Cardiovascular Hemodynamics in the Management of Cardiovascular DiseasesView all 14 articles
A Systematic Quantification of Hemodynamic Differences Persisting After Aortic Coarctation Repair
Provisionally accepted
- 1Duke University, Durham, North Carolina, United States
- 2Duke University Medical Center, Duke University, Durham, North Carolina, United States
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Introduction: Aortic coarctation (CoA) comprises 6-8% of all congenital heart diseases and is the second most common cardiovascular disease requiring neonatal surgical correction. However, patients remain at high risk for long-term complications, notably recoarctation. Methods: Hemodynamic simulations were performed in a group of six patients following CoA repair, as compared to a group of age and sex-matched healthy controls. Progressive narrowing at the CoA repair site was modeled to simulate the recoarctation process. Key measurements included time-averaged wall shear stress (TAWSS) in the aortic arch and CoA repair site. Results: Repaired aortas demonstrated significantly higher TAWSS compared to healthy aortas in the aortic arch (3.46 vs. 1.24 Pa, p < 0.05) and CoA repair site (4.34 vs. 1.56 Pa, p < 0.05). A pronounced nonlinear relationship between stenosis severity and TAWSS was observed suggesting that increasing stenosis corresponds to progressively abnormal shear stress. Discussion: The persistent high TAWSS in CoA-repaired aortas may underlie the poor long-term outcomes observed in this population. The identified nonlinear relationship between stenosis severity and TAWSS magnitude suggests a potential positive feedback mechanism, where abnormal shear stress exacerbates pathologic remodeling in the repaired aorta, highlighting the potential role of hemodynamic simulations in the clinical management of CoA patients.
Keywords: Aortic coarctaction, computational fluid dynamics, late aneurysmal degeneration, restenosis, long-term complications of coarctation
Received: 04 Dec 2024; Accepted: 30 May 2025.
Copyright: © 2025 Jensen, Ghorbannia, Urick, Hughes and Randles. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Amanda Randles, Duke University, Durham, 27708, North Carolina, United States
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