ORIGINAL RESEARCH article
Front. Bioeng. Biotechnol.
Sec. Biosensors and Biomolecular Electronics
Volume 13 - 2025 | doi: 10.3389/fbioe.2025.1564510
This article is part of the Research TopicBiomedical Sensing in Assistive DevicesView all 9 articles
Non-Invasive Bio-Electromagnetic Monitoring of Cerebrovascular Function: A Novel Conductivity Reactivity Index (CRx) for Optimal Cerebral Perfusion Pressure in Acute Brain Injury Models
Provisionally accepted
- 1College of Biomedical Engineering and Medical Imaging, Army Medical University, Chongqing, China
- 2Department of Medical Engineering, General Hospital of Central Theater Command, Wuhan, China
- 3School of Pharmacy and Bioengineering, Chongqing University of Technology, Chongqing, China
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The pressure reactivity index (PRx) is a key predictor of cerebrovascular function, widely used to guide and optimize therapeutic strategies in patients with acute brain injury. This study investigates a noninvasive bio-electromagnetic technique for monitoring and maintaining cerebrovascular function in a rabbit model of acute brain injury. A coaxial parallel double-coil sensor was designed to detect changes in intracranial electromagnetic properties, measured as magnetic induction phase shifts (MIPS), which reflect cerebral blood volume fluctuations. A cerebrovascular function monitoring platform was constructed with this sensor, a vector network analyzer, a LabVIEW software platform, and a physiological signal acquisition device to record the MIPS and arterial blood pressure (ABP). In the animal experiment, a novel cerebrovascular function index Conductivity Reactivity index (CRx), established with MIPS and ABP, was to assess optimal cerebral blood perfusion pressure (CPP) for maintaining the cerebrovascular function in four gradients of CPP in acute brain injury model. The results found that the CRx (-0.072 ± 0.203) was a significant negative correlation with the PRx (0.223 ± 0.203) (r = -0.447, P = 0.003). Under the optimal CPP determined by the CPP-CRx curve, the mean CRx (0.104 ± 0.170) indicated normal cerebrovascular function, which was significantly different from the other states (CRx = -0.127 ± 0.061, p = 0.009). The results demonstrated that CRx has potential to reflect cerebrovascular function dynamics and assess optimal CPP, demonstrating the potential of bioelectromagnetic technology as a non-invasive indicator for monitoring cerebrovascular function.
Keywords: Magnetic induction phase shift, Bio-electromagnetic technology, Cerebrovascular function, Optimal cerebral perfusion pressure, Conductivity reactivity index
Received: 21 Jan 2025; Accepted: 24 Jun 2025.
Copyright: © 2025 Xu, Li, Wang, Yan, Jin, Chen, Li and Qin. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Gen Li, School of Pharmacy and Bioengineering, Chongqing University of Technology, Chongqing, China
Mingxin Qin, College of Biomedical Engineering and Medical Imaging, Army Medical University, Chongqing, China
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