Dynamic behavior of the nucleus pulposus within the intervertebral disc loading : a systematic review and metaanalysis exploring the concept of Dynamic Disc Model

Jean-Philippe Deneuville^1,2,3*Maxime Billot¹Alexandra Cervantes²Sylvain Peterlongo²Martin Meyer²Mesika Kolder²Marie Escande⁴Mathilde Bourgeois⁴Adrien Pallot^4,5Romain David^1,3,6Manuel Roulaud¹Amine Ounajim¹Mark Laslett⁷Mathieu Sarracanie⁸Najat Salameh⁸Arnaud Germaneau³Philippe Rigoard^1,3,6

• ¹Laboratoire de Recherche Prismatics, Centre Hospitalier Universitaire (CHU) de Poitiers, Poitiers, France
• ²Association Francophone McKenzie (AFMcK – McKenzie Francophonic Association), Paris, France, Paris, France
• ³UPR3346 Institut P' Recherche et Ingénierie en Matériaux, Mécanique et Energétique (Pprime), Poitiers, Poitou-Charentes, France
• ⁴Centre Européen d’Enseignement en Rééducation et Réadaptation Fonctionnelle (CEERRF – European Center for Education in Rehabilitation and Functional Rehabilitation), Saint Denis, France., Saint-Denis, France
• ⁵Institut d’Ingénierie de la Santé, Université de Picardie Jules Verne, 80000 Amiens, France, Amiens, France
• ⁶Department of Spine, Pain and Disability Neurosurgery, Poitiers University Hospital, Poitiers, France., Poitiers, France
• ⁷The Sports Clinic, 156 Bealey Ave., Christchurch, New Zealand., Christchurch, New Zealand
• ⁸Center for Adaptable MRI Technology, Institute of Medical Sciences, School of Medicine, Medical Sciences and Nutrition, University of Aberdeen, Aberdeen, United Kingdom, Aberdeen, United Kingdom

Introduction: The dynamic disc model (DDM) is a theoretical framework in spine mechanics that theorizes the behavior of the nucleus pulposus within the intervertebral disc under various loads. The model predicts displacement of the nucleus pulposus away from the bending loads, for example backward displacement of the nucleus pulposus with a flexion load. These predictions are regularly used as a theoretical basis for explaining certain disc pathologies, such as disc herniation.Methods: We screened seven databases (CENTRAL, Embase, MEDLINE, CINAHL, ScienceDirect, Google Scholar, and HAL) up to July 2024, identifying studies through a PRISMA-guided approach that detailed the mechanical transformation (displacement and deformation) of the nucleus pulposus under bending load on the intervertebral disc. We conducted a double-blind data extraction and quality assessment of the body of evidence. Finally, we performed a meta-analysis of proportions.Results: From the 9,269 articles screened, 14 studies were included in the systematic review and meta-analysis. Magnetic Resonance Imaging (MRI) was employed in 92.8% of the studies, revealing four strategies for assessing nucleus pulposus transformation. The meta-analysis of asymptomatic subjects’ data demonstrated that the nucleus pulposus behavior aligned with dynamic disc model predictions in 85.4% (95% CI = [79.4 – 91.4]) across spinal regions and bending directions. However, significant heterogeneity and low study quality were noted. Only one study used discography to assess the DDM in a discogenic pain population, identifying discrepancies in nucleus pulposus transformation and contrast agent leakage.Conclusion: Evidence for the dynamic disc model for intact discs is of low strength, whereas very limited evidence challenges the dynamic disc model for fissured discs. New multiparametric MRI studies may help guiding future clinical assessment protocols.