REVIEW article

Front. Bioeng. Biotechnol.

Sec. Biomaterials

Volume 13 - 2025 | doi: 10.3389/fbioe.2025.1586898

This article is part of the Research TopicAdvanced Biomaterials and Surface Engineering and Technology of Orthopedic ImplantsView all 3 articles

Research progress of implantable materials in antibacterial treatment of bone infection

Provisionally accepted
Binqing  XiangBinqing Xiang1Jingui  JiangJingui Jiang2Heng  WangHeng Wang1Lei  SongLei Song1*
  • 1First Affiliated Hospital, Army Medical University, Chongqing, China
  • 2Army Medical University, Chongqing, China

The final, formatted version of the article will be published soon.

Abstract:Bone infection is an infectious disease characterized by the accumulation of various pathogens in bone tissue, often causing significant suffering to patients. Current therapeutic approaches for bone infections predominantly rely on the postoperative application of implantable antibacterial materials, highlighting their essential role in clinical treatment. In this review, we systematically analyze research progress in antibacterial implant materials for Bone infection from 2019 to 2025. Materials are classified into four categories based on matrix composition: metalbased composite implants, bioceramic-based composite implants, polymer-based composite implants, and other composite implant materials, with dedicated focus on the limitations of each material type. The deterioration effects of these materials are also thoroughly analyzed. Finally, we present our own insights regarding future development directions of antibacterial implant materials. This review aims to provide practical references and research perspectives for advancing antibacterial implant material development.

Keywords: bone infection, Implantable materials, Antibacterial treatment, Composite materials, Material matrix

Received: 03 Mar 2025; Accepted: 07 Jul 2025.

Copyright: © 2025 Xiang, Jiang, Wang and Song. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence: Lei Song, First Affiliated Hospital, Army Medical University, Chongqing, China

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