REVIEW article
Front. Bioeng. Biotechnol.
Sec. Biomaterials
Volume 13 - 2025 | doi: 10.3389/fbioe.2025.1586898
This article is part of the Research TopicAdvanced Biomaterials and Surface Engineering and Technology of Orthopedic ImplantsView all 3 articles
Research progress of implantable materials in antibacterial treatment of bone infection
Provisionally accepted
- 1First Affiliated Hospital, Army Medical University, Chongqing, China
- 2Army Medical University, Chongqing, China
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Abstract：Bone infection is an infectious disease characterized by the accumulation of various pathogens in bone tissue, often causing significant suffering to patients. Current therapeutic approaches for bone infections predominantly rely on the postoperative application of implantable antibacterial materials, highlighting their essential role in clinical treatment. In this review, we systematically analyze research progress in antibacterial implant materials for Bone infection from 2019 to 2025. Materials are classified into four categories based on matrix composition: metalbased composite implants, bioceramic-based composite implants, polymer-based composite implants, and other composite implant materials, with dedicated focus on the limitations of each material type. The deterioration effects of these materials are also thoroughly analyzed. Finally, we present our own insights regarding future development directions of antibacterial implant materials. This review aims to provide practical references and research perspectives for advancing antibacterial implant material development.
Keywords: bone infection, Implantable materials, Antibacterial treatment, Composite materials, Material matrix
Received: 03 Mar 2025; Accepted: 07 Jul 2025.
Copyright: © 2025 Xiang, Jiang, Wang and Song. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Lei Song, First Affiliated Hospital, Army Medical University, Chongqing, China
Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.