Application and progress of temperature-sensitive hydrogels in cartilage injury repair

Long Yu¹Kunhao She¹Rui He¹Qingyu Xu^1,2*

• ¹Department of pediatric Surgery,Hong Qi Hospital affiliated to Mudanjiang Medical University, Mudanjiang, China
• ²Mudanjiang Medical University, Mudanjiang, China

【Abstract】Articular cartilage injury is an important challenge in the field of orthopedics. Due to its unique characteristics of being vascularless, neuralless, and without lymphoid tissue, as well as the poor proliferation and migration ability of chondrocytes, the self-repair ability of cartilage after injury is limited.In recent years, with the development of tissue engineering, temperature-sensitive hydrogels, as a new type of biomedical material, have unique temperature-responsive phase transition characteristics (such as the phase transition critical point close to the physiological temperature), which enable them to rapidly form a stable three-dimensional porous structure triggered by body temperature after being injected into the joint cavity. It has injectable property, in-situ gelation property and the ability to construct a dynamic bionic ECM microenvironment. Compared with chemically cross-linked hydrogels, this material can achieve precise spatiotemporal control without introducing exogenous stimuli, significantly reducing the risk of cytotoxicity. Through adjustable mechanical properties, highly efficient loading and release of bioactive factors, as well as viscoelastic characteristics similar to natural cartilage matrices, it has shown great potential in the repair of articular cartilage injuries. This article reviews the research progress of temperature-sensitive hydrogels in the repair of articular cartilage injuries from aspects such as biological characteristics, mechanism of action, clinical applications and challenges faced, providing new ideas and possibilities for cartilage injury repair.