ORIGINAL RESEARCH article
Front. Bioeng. Biotechnol.
Sec. Bioprocess Engineering
Volume 13 - 2025 | doi: 10.3389/fbioe.2025.1603975
Adaptive Responses of Gordonia alkanivorans IEGM 1277 to the Action of Meloxicam and its Efficient Biodegradation
Provisionally accepted
- 1Institute of Ecology and Genetics of Microorganisms (RAS), Perm, Perm Krai, Russia
- 2Winogradsky Institute of Microbiology, Russian Academy of Sciences (RAS), Moscow, Moscow Oblast, Russia
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The ability of Gordonia actinomycetes to completely biodegrade meloxicam was demonstrated for the first time. G. alkanivorans IEGM 1277 cells demonstrated the conversion of meloxicam into less complex compounds. The composition of produced primary metabolites, hydroxymethyl-and carboxymeloxicam, with less pronounced (eco)toxicity compared to meloxicam, was identified by the liquid chromatography-mass spectrometry. A number of G. alkanivorans IEGM 1277 candidate genes encoding meloxicam oxidation enzymes were identified. Adaptive responses of Gordonia to meloxicam exposure, accompanied by phenotypic and metabolic changes in bacterial cells, were revealed using atomic-force microscopy, transmission electron microscopy, and energy-dispersive Xray spectroscopy. The obtained data on the complex bilateral interaction in the system "bacteriapharmaceuticals" and the efficiency of the triggered defense-adaptive reactions of bacterial cells are useful for the development of effective environmentally safe methods of industrial wastewater treatment from pharmaceuticals.
Keywords: Non-Steroidal Anti-Inflammatory Drugs (NSAIDs), Meloxicam, pharmaceutical pollution, Gordonia, Biodegradation, bacterial cell responses
Received: 01 Apr 2025; Accepted: 04 Jul 2025.
Copyright: © 2025 Tyan, Kostrikina, Sorokin, Mulyukin and Ivshina. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Semyon Tyan, Institute of Ecology and Genetics of Microorganisms (RAS), Perm, Perm Krai, Russia
Irina Ivshina, Institute of Ecology and Genetics of Microorganisms (RAS), Perm, Perm Krai, Russia
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