REVIEW article
Front. Bioeng. Biotechnol.
Sec. Organoids and Organ-On-A-Chip
Volume 13 - 2025 | doi: 10.3389/fbioe.2025.1607488
This article is part of the Research TopicInnovative Organoid Co-Culture Systems for Enhanced Precision Medicine in Cancer and BeyondView all articles
Organoids in Cancer Therapy: A Comprehensive Review
Provisionally accepted
- 1Hangzhou Medical College, Hangzhou, China
- 2Ningbo Second Hospital, Ningbo, Zhejiang Province, China
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Organoid technology has significantly advanced biomedical research, offering deep insights into tumor biology and therapeutic efficacy. While existing publications have covered organoid applications, this review uniquely stresses their transformative role in cancer research. We highlight their importance in studying intratumoral heterogeneity and microenvironment interactions. Our analysis addresses knowledge gaps by detailing how organoids function as models in cancer initiation, drug screening, target identification, and sensitivity assessment. We also explore their applications in personalized medicine, such as developing patient-derived models for treatment prediction and immune therapy evaluation.This review discusses the latest progress in using organoids for cancer treatment, like predicting patient responses to precision medicine. However, challenges remain, including maintaining genetic stability and mimicking in vivo conditions. By addressing these limitations, this review provides a novel perspective on how organoid technology may overcome current barriers and drive innovation in cancer therapy. Our analysis suggests that advancements in organoid systems could enhance personalized treatment strategies and improve oncology patient outcomes.
Keywords: organoids1, Cancer therapy2, Disease modeling3, Drug Screening4, personalized medicine5
Received: 07 Apr 2025; Accepted: 08 Jul 2025.
Copyright: © 2025 Jiang, Yan-Ran, Pin-Ru, Shi-Yi and Haitao. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Jiang Haitao, Ningbo Second Hospital, Ningbo, 315010, Zhejiang Province, China
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