ORIGINAL RESEARCH article
Front. Bioeng. Biotechnol.
Sec. Nanobiotechnology
Volume 13 - 2025 | doi: 10.3389/fbioe.2025.1608188
This article is part of the Research TopicIntegrative Stimuli-Responsive Biomaterials: Shaping the Future of Precision NanomedicineView all 4 articles
pH-triggered CS@ZnO2 nanocomposites: self-activated ROS generation for efficient bacterial eradication
Provisionally accepted
- The Fourth Hospital of Changsha (Integrated Traditional Chinese and Western Medicine Hospital of Changsha), Changsha, China
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Functional nanomaterials based on reactive oxygen species (ROS) have attracted considerable attention in the treatment of bacterial infections, owing to their high sterilization efficiency and low tendency to induce drug resistance. Natural polymers, known for their excellent biocompatibility, have been widely used in the development of antibacterial dressings. In this study, chitosan-zinc peroxide composite dressing (CS@ZnO2) was synthesized using zinc acetate and chitosan as primary raw materials, and comprehensive characterizations were performed. Under the slightly acidic conditions of bacterial infections, CS@ZnO2 could self-decompose to release H2O2 and produce large amount of ROS, which would cause damage to bacteria. The in vitro antibacterial properties of CS@ZnO2 were investigated using Escherichia coli (E. coli) and Staphylococcus aureus (S. aureus) as representative pathogens. The results demonstrated that CS@ZnO2 exhibited potent antibacterial efficacy against both S. aureus and E. coli. This research provides an important theoretical foundation and technical support for the development of novel antibacterial materials, and has the potential to improve the efficacy of treatments for bacterial infections in the future.
Keywords: Chitosan, Zinc peroxide, Self-supply H2O2, Reactive Oxygen Species, Antibacterial
Received: 08 Apr 2025; Accepted: 08 May 2025.
Copyright: © 2025 Zhang, Liu, Li, Zhou, Liu and Huang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Yu Zhang, The Fourth Hospital of Changsha (Integrated Traditional Chinese and Western Medicine Hospital of Changsha), Changsha, China
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