ORIGINAL RESEARCH article
Front. Bioeng. Biotechnol.
Sec. Biomaterials
Volume 13 - 2025 | doi: 10.3389/fbioe.2025.1609673
Dual-Functional Injectable Adhesive Hydrogel Delivering Ginger-Derived Doxorubicin Vesicles for Osteosarcoma Recurrence Suppression and Post-Resection Wound Healing
Provisionally accepted
- 1Tianjin Medical University Cancer Institute and Hospital, Tianjin, Tianjin, China
- 2National Clinical Research Center for Cancer, Tianjin Medical University Cancer Institute and Hospital, Tianjin, China
- 3Key Laboratory of Cancer Prevention and Therapy, Tianjin Medical University Cancer Institute and Hospital, Tianjin, China
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Elderly osteosarcoma patients frequently encounter significant postoperative challenges, such as high recurrence rates and impaired wound healing, primarily resulting from inadequate hemostasis, reactive oxygen species (ROS)-mediated microenvironmental inhibition, and compromised bone regeneration capacity. To address these challenges, this study introduces a multifunctional adhesive hydrogel designed for synergistic therapy, incorporating ginger vesicles (GVs) loaded with doxorubicin (DOX). The hydrogel comprises carboxymethyl chitosan methacryloyl (CMCSMA) and tannic acid (TA), forming a dynamic, crosslinked polymer network that enables rapid tissue adhesion and effective adaptability to moist wound environments. It precisely conforms to complex bone defects, facilitating efficient hemostasis through physical barrier formation and activation of coagulation factors. Furthermore, the hydrogel system delivers dual therapeutic actions through controlled release of GVs and DOX. Ginger vesicles, rich in natural antioxidants, scavenge ROS, attenuate inflammatory responses, and supply bioactive molecules that enhance angiogenesis and osteogenesis, thereby promoting wound healing and bone regeneration. Simultaneously, sustained release of DOX targets and eliminates residual tumor cells, effectively reducing postoperative recurrence. In vitro experiments confirm the hydrogel’s efficacy in ROS removal and promotion of osteogenic differentiation. Additionally, in a rat osteosarcoma resection model, the hydrogel significantly shortens hemostasis time compared with conventional sponge, decreases tumor recurrence, and accelerates wound healing. Collectively, this research proposes an integrated therapeutic strategy combining hemostasis, antioxidation, tissue repair, and recurrence prevention, highlighting the hydrogel's substantial potential for clinical translation in elderly osteosarcoma treatment.
Keywords: Postoperative osteosarcoma management, Ginger vesicles, adhesive hydrogel, Doxorubicin, Antioxidation-enhanced bone regeneration, Tumor recurrence inhibition
Received: 10 Apr 2025; Accepted: 09 Jun 2025.
Copyright: © 2025 Zhang, Zhang, Chen, Sun, Zhang, Yue, Wang and Zhang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Zhenfa Zhang, National Clinical Research Center for Cancer, Tianjin Medical University Cancer Institute and Hospital, Tianjin, China
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