ORIGINAL RESEARCH article
Front. Bioeng. Biotechnol.
Sec. Biomaterials
Volume 13 - 2025 | doi: 10.3389/fbioe.2025.1611948
This article is part of the Research TopicAdvanced Technologies for Oral and Craniomaxillofacial TherapyView all 13 articles
Multifunctional PLGA/collagen/zeolitic imidazolate framework-8 composite nanofibrous membranes for guided bone regeneration
Provisionally accepted
- 1Harbin Medical University, Harbin, China
- 2Harbin Institute of Technology, Harbin, Heilongjiang Province, China
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Guided bone regeneration (GBR) techniques have been extensively utilized in the treatment of maxillofacial bone defects. Nevertheless, the construction of supportive membranes to overcome the current deficiencies of clinical GBR membranes in terms of osteoinduction and antimicrobial resistance remains challenging. This study addresses the therapeutic requirements for critical bone defects through development of collagen (Col) and zeolitic imidazolate framework-8 (ZIF-8) reinforced poly(lactide-co-glycolide) (PLGA) nanofibrous membranes. These GBR constructs were fabricated using electrospinning technology to integrate bioactive components within a biodegradable polymer matrix. Optimization of the PLGA/Col weight ratio (100:3) yielded composite membranes demonstrating superior tensile strength. The PLGA/Col/ZIF-8 nanofibrous composite incorporating 1 wt% ZIF-8 nanoparticles exhibited optimal biocompatibility with sustained Zn 2+ release kinetics. In vitro experiments demonstrated that sustained release of Zn 2+ has the dual effects of stimulating osteogenic differentiation and effectively preventing early bacterial infection. In vivo a rat calvarial defect model further confirmed the positive bone regeneration effect of the PLGA/Col/ZIF-8 composite nanofibrous membrane. In conclusion, PLGA/Col/ZIF-8 composite nanofibrous membranes have great potential for application in guiding bone tissue regeneration.
Keywords: Electrospinning, Nanofibrous membrane, ZIF-8, Tensile Strength, Guided bone regeneration
Received: 15 Apr 2025; Accepted: 13 Jun 2025.
Copyright: © 2025 Wang, Xie, Liang, Sun and Xie. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Weili Xie, Harbin Medical University, Harbin, China
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