ORIGINAL RESEARCH article
Front. Bioeng. Biotechnol.
Sec. Biomaterials
Volume 13 - 2025 | doi: 10.3389/fbioe.2025.1615481
This article is part of the Research TopicMultifunctional nanomaterials: Stand in the Center of Cancer Therapy as well as Tissue Regeneration and RepairView all 6 articles
Ultrasound-controllable Carbon Monoxide Nano-delivery Systems for Combined Sonodynamic/gaseous Therapies
Provisionally accepted
- 1Ultrasound Department of Hong Qi Hospital of Mudanjiang Medical University, Mudanjiang, China
- 2Health Management Center, Mudanjiang First People's Hospital, Health Management Center, Mudanjiang First People's Hospital, China
- 3Department of Biology, School of Basic Medical Sciences, Mudanjiang Medical University, Mudanjiang, China
- 4Ultrasound Department of Second Hospital of Mudanjiang Medical University, Mudanjiang, China
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The integration of sonodynamic therapy (SDT) and carbon monoxide (CO) presents a promising synergistic strategy in cancer therapy owing to the unique advantage of CO in SDT sensitization. However, the development of SDT-compatible CO-delivery nanosystems remain a substantial challenge. Here, we developed an ultrastable and controllable CO nanoreservoir system through the integration of chlorine e6 (Ce6)-loaded, cancer cell membrane coating and iron carbonyl (Fe3CO12)bridged mesoporous silica bodies (Fe3CO12-MSNs), which was specifically engineered to simultaneously achieve SDT and ultrasound (US)-responsive sustained CO release. Owing to the stabilization of Fe3CO12 within the silica framework, Fe3CO12-MSNs not only decreased unwanted CO leakage during transport but also enabled US-responsive matrix degradation accompanied by sustained CO release at tumor sites, which prolongs the therapeutic window of CO and maximizes the synergy of SDT and CO therapy. This nanoplatform-mediated combination therapies showed highly efficient antitumor effects and triggered a robust tumor-specific immune responses. When in combination with immune checkpoint blockers, the nanoplatform notably eradicate the breast cancer with low systematic toxicity. Overall, our work provides a promising nanoplatform with US-responsive and sustainable CO release for highly efficient and safe SDT/CO combined therapeis.
Keywords: Sonodynamic therapy1, Gaseous Therapy2, Breast cancer3, Hybrid materials4, Controlled release5
Received: 21 Apr 2025; Accepted: 29 May 2025.
Copyright: © 2025 Feng, Song, Zhang, Wang, Meng and Wang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Tao Wang, Ultrasound Department of Second Hospital of Mudanjiang Medical University, Mudanjiang, China
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