HYPOTHESIS AND THEORY article
Front. Bioeng. Biotechnol.
Sec. Biomaterials
Volume 13 - 2025 | doi: 10.3389/fbioe.2025.1619084
This article is part of the Research TopicAdvanced Biomaterials and Surface Engineering and Technology of Orthopedic ImplantsView all 5 articles
An ideal biomaterial: Ti-based bone repair material with dual-response antibacterial system and sustained drug release
Provisionally accepted
Wentao Zhang1
Zhaoyang Guo1
Zhongyuan He1
Hang Zhou1Hang Liu1Xinliang Pen1Xingyu Yang1Ru Zhong2Wen Huang2Lei Chu1*Zhongliang Deng1*- 1Department of Orthopaedics, Second Affiliated Hospital, Chongqing Medical University, Chongqing, China
- 2National Engineering Research Center for Tissue Restoration and Reconstruction, South China University of Technology, Guangzhou, China
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Bone infection is a disease with high treatment cost, long period and high disability rate in orthopedics. The development of antibacterial implant materials in vivo can alleviate the pain of patients and social burden. Enhancing the biocompatibility of titanium-based implants through surface modification is a breakthrough to solve aseptic loosening, and h How to make the antibacterial substances in the implant materials release regularly as needed is a key technical breakthrough that antibacterial bone repair implants have been trying to optimize. It has been proved that metal silver ions sputtering can form higher specific surface area on the surface of implanted materials, and can produce electron biological effect to realize in-situ sterilization, and promote angiogenesis. Antibacterial peptide crosslinked with hyaluronic acid can be hydrolyzed by hyaluronidase during bacterial infection, thus killing free bacteria, producing immune regulation and repairing tissue damage. At present, it is planned to use titanium dioxide nanotubes to construct a double-layer nanotube structure, fill osteogenic drugs into the nanotubes by vacuum-assisted physical adsorption, and sputter deposit metal silver ions on the surface of the nanotubes. The outer layer of the material is prepared by covalent grafting of antibacterial peptides and hyaluronic acid to prepare a layer-by-layer assembly technology shell to prepare a bone implant scaffold material with dual sterilization response systems of electronic biological antibacterial response and enzymatic hydrolysis antibacterial response.
Keywords: bone infection, Antibacterial, electronic biological response, enzymatic hydrolysis response, Bone repair, Titanium-based materials
Received: 27 Apr 2025; Accepted: 26 Aug 2025.
Copyright: © 2025 Zhang, Guo, He, Zhou, Liu, Pen, Yang, Zhong, Huang, Chu and Deng. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Lei Chu, Department of Orthopaedics, Second Affiliated Hospital, Chongqing Medical University, Chongqing, China
Zhongliang Deng, Department of Orthopaedics, Second Affiliated Hospital, Chongqing Medical University, Chongqing, China
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