MINI REVIEW article
Front. Bioeng. Biotechnol.
Sec. Biomaterials
Volume 13 - 2025 | doi: 10.3389/fbioe.2025.1621418
This article is part of the Research TopicMulti-Modal Imaging and Natural Products Nanomedicine Platform for Advancing Imaging-Guided Diagnosis and TherapeuticsView all articles
Advancements in the Investigation of Radioactive Microspheres for Brachytherapy
Provisionally accepted
- 1Jining University, Jining, China
- 2Southern Medical University, Guangzhou, China
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In clinical practice, the management of most non-surgically resectable solid tumors necessitates a multidisciplinary treatment (MDT) approach. Optimal solutions involve the integration of local and systemic treatments, such as targeted immunotherapy and chemotherapy. Micron-sized radioactive microspheres or particles have gained widespread application in the localized treatment of various organ tumors, encompassing liver cancer, lung cancer, tongue cancer, pancreatic cancer, head and neck cancer, ovarian cancer, bone cancer, among others. As such, the design and development of novel multifunctional radioactive microspheres constitute a crucial foundation for achieving effective local treatment in liver cancer and other cancer types. This article critically reviews the current developmental landscape, identifies challenges, and explores opportunities in the field of radioactive internal irradiation microspheres in recent years. The insights provided serve as a valuable reference for selecting and determining the developmental direction of clinical brachytherapy treatment carriers.
Keywords: tumor, Radiation, Brachytherapy, Radioactive microspheres, theranostics
Received: 01 May 2025; Accepted: 08 Jul 2025.
Copyright: © 2025 Jiang, Chen and Xu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Xiao Xu, Southern Medical University, Guangzhou, China
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