REVIEW article
Front. Bioeng. Biotechnol.
Sec. Biomaterials
Volume 13 - 2025 | doi: 10.3389/fbioe.2025.1625550
This article is part of the Research TopicThe Application of Novel Biomaterials and Emerging Techniques in Musculoskeletal DisordersView all articles
Recent Advances in Bionic Scaffolds for Cartilage Tissue Engineering
Provisionally accepted
Yushan Zhang1
Weihan Yu2*- 1Xinchang Hospital Affiliated to Wenzhou Medical University, Xinchang, Zhejiang, China
- 2Shanghai General Hospital, Shanghai, China
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Articular cartilage is difficult to regenerate. It often leads to osteoarthritis after injury, which seriously affects the quality of life of patients. Presently, the clinical treatments of articular cartilage injury have certain limitations. With the development of tissue engineering, cartilage repair becomes possible. Different types of bionic scaffolds have shown great application potential in cartilage repair. We reviewed the characteristics of ideal bionic scaffolds, including biocompatibility, biodegradability, mechanical and structural properties, bioactivity and functionality. We also summarized the latest research progress of different bionic scaffolds in recent years, hoping to provide a reference for the design of bionic scaffolds with stable performance and definite efficacy, and help them to be gradually applied in clinical practice.
Keywords: Bionic scaffolds, Cartilage, Osteoarthritis, Regeneration, Tissue Engineering
Received: 09 May 2025; Accepted: 04 Jun 2025.
Copyright: © 2025 Zhang and Yu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Weihan Yu, Shanghai General Hospital, Shanghai, China
Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.