ORIGINAL RESEARCH article
Front. Bioeng. Biotechnol.
Sec. Biomaterials
Volume 13 - 2025 | doi: 10.3389/fbioe.2025.1629244
Accelerating wound healing by biomineralizing crystallization formed from ZIF-8/PLA nanofibers with enhanced revascularization and inflammation reduction
Provisionally accepted
Xiangsheng Wang1*
Xueer Zhang2
Bingqian Wang3Zhixiang Tan4Mulan Chen2Haiyan Shen1Hanxiao Cheng1Zhentao Zhou1
Zhanyong Zhu4
Jing Guo2Jufang Zhang1- 1Hangzhou First People's Hospital, Hangzhou, China
- 2Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, China
- 3Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
- 4Renmin Hospital of Wuhan University, Wuhan, China
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Nanofiber dressings have three-dimensional support structure, small pore size, and high surface-to-volume ratio and can simulate the extracellular matrix (ECM), which is beneficial for cell growth, adhesion, and proliferation. Polylactic acid (PLA) is a synthetic polymer material with good biodegradability, biocompatibility, and bioabsorbability, electrospinning is a convenient and efficient method for preparing PLA nanofibers with relatively low equipment costs. However, PLA nanofibers as wound dressings lack biological functions, including promoting angiogenesis, extracellular matrix secretion and regulating inflammation, which are crucial for skin regeneration. Herein, we report an phenomenon in which ZIF-8 forms large hydroxyapatite-like crystals when immersed directly in multi-ion simulated body fluid. The above phenomenon was also observed on the surface of ZIF-8/PLA electrospinning nanofibers. ZIF-8-induced biomineralization increased the roughness of PLA nanofibers by altering its surface topography, which significantly improved its biocompatibility. The Zinc and calcium ions released from hydroxyapatite-like crystals induced by ZIF-8 also significantly promotes angiogenesis, enhances extracellular matrix deposition and reduces inflammatory infiltration in wound healing model. In summary, this study demonstrates that ZIF-8 may serve as a bioactive additive that enables the surface modification of synthetic polymers, suggesting that it can be applied in in-situ skin regeneration.
Keywords: Nanofibers, Metal-organic framework, Polylactic Acid, biomimetic mineralization, Wound Healing
Received: 15 May 2025; Accepted: 11 Aug 2025.
Copyright: © 2025 Wang, Zhang, Wang, Tan, Chen, Shen, Cheng, Zhou, Zhu, Guo and Zhang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Xiangsheng Wang, Hangzhou First People's Hospital, Hangzhou, China
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