ORIGINAL RESEARCH article
Front. Bioeng. Biotechnol.
Sec. Biomechanics
Volume 13 - 2025 | doi: 10.3389/fbioe.2025.1629362
Influence of Valve Size on the Hemodynamic Performance of a Tissue-Engineered Valved Conduit in Pulmonary Position
Provisionally accepted
- 1ARTORG Center for Biomedical Engineering Research, Faculty of Medicine, University of Bern, Bern, Switzerland
- 2Xeltis BV, Eindhoven, Netherlands
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Tissue engineering (TE) uses resorbable polymers to promote in-situ cellular growth, transforming the implant into a living valve. This study characterizes the three-dimensional flow field around TE valved conduits of varying sizes using a pulse duplicator with tomo-PIV imaging. Three Xeltis Pulmonary Valve (XPV) conduits (16, 18, and 20mm) were tested under pulmonary conditions at a cardiac output of 5l/min. Flow velocities, trans-valvular pressure gradients (TVPGs), effective orifice areas EOAs, mean and turbulent kinetic energies (mke and tke), and viscous shear stresses were measured proximal and distal to the valves. Peak bulk velocity was 0.5, 0.4, and 0.3m/s, with local peak velocities reaching 2.3, 1.9, and 1.4m/s upstream and 3.6, 3.1, and 2.5m/s in the jet downstream of XPV16, XPV18, and XPV20, respectively. Respective EOAs were 1.02, 1.25, and 1.57cm2. The flow field proximal to the valve conduits did not show any significant perturbations and tke was one order of magnitude lower than mke. As the flow passed the valve, mke increased by 152%, 175%, and 218% for XPV16, XPV18, and XPV20, respectively, while tke increased by 62%, 138%, and 161%. The respective probability of encountering elevated shear stresses (>10Pa) was 6%, 2%, and less than 1%. This work provides the first in-vitro experimental assessment of the XPV valve, along with an exploration of how valve size affects its hemodynamic performance. Results confirm that for a given hemodynamic condition, larger valves exhibit better performance showing lower flow velocities, TVPGs, kinetic energies, and stresses, along with higher EOAs.
Keywords: heart valve, Tomo-PIV, In-vitro, Shear stresses, Shake-The-Box
Received: 15 May 2025; Accepted: 08 Aug 2025.
Copyright: © 2025 Ferrari, Cox and Obrist. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Lorenzo Ferrari, ARTORG Center for Biomedical Engineering Research, Faculty of Medicine, University of Bern, Bern, Switzerland
Dominik Obrist, ARTORG Center for Biomedical Engineering Research, Faculty of Medicine, University of Bern, Bern, Switzerland
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