ORIGINAL RESEARCH article
Front. Bioeng. Biotechnol.
Sec. Biomechanics
Volume 13 - 2025 | doi: 10.3389/fbioe.2025.1630854
Acute effects of mechanical dyssynchrony on left ventricular function and coronary perfusion
Provisionally accepted
- 1California Medical Innovations Institute, San Diego, United States
- 2Department of Mechanical Engineering, Michigan State University, East Lansing, Michigan, United States
- 3University of California San Diego, San Diego, United States
- 4Michigan State University, East Lansing, United States
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Background – Patients with heart failure frequently develop mechanical dyssynchrony, which impairs ventricular function, coronary perfusion and their interactions. The underlying mechanisms, however, remain poorly understood due to numerous confounding factors. The objective of this study was to determine the acute effects of mechanical dyssynchrony on global and regional left ventricular (LV) function, coronary perfusion and their interactions based on experimental and computational approaches. Methods – Mechanical dyssynchrony was created with right ventricular apical pacing in Yorkshire domestic swine (n = 9). The heart was paced at 100 and 140 bpm and the results were compared to right atrial pacing. An inverse finite element computational framework based on an animal-specific geometry of the LV and measurements was developed to investigate the effects of mechanical dyssynchrony on LV function and its correlation with regional coronary perfusion. Results – Cardiac dyssynchrony induced significant decrease in LV pressure, volume, dP/dt(min), stroke volume, ejection fraction, and regional longitudinal and circumferential strain. With mechanical dyssynchrony, passive flow decreased by 70% in the left anterior descending artery (LAD) and 67% in the left circumflex (LCX). An animal-specific inverse finite element computational model predicted that in mechanical dyssynchrony, global and regional LV contractility in the septum and LV free wall (LVFW), and myocardial work done in the septum and LVFW decreased. Conclusions – The computational model predicted reduction in global and regional contractility, and regional myocardial work done in the septum and LVFW with mechanical dyssynchrony are
Keywords: mechanical dyssynchrony, Right ventricular pacing, left ventricular hemodynamics, left ventricular function, coronary blood flow
Received: 18 May 2025; Accepted: 01 Sep 2025.
Copyright: © 2025 Choy, Fan, Awakeem, Cai, Raissi, Lee and Kassab. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Ghassan S Kassab, California Medical Innovations Institute, San Diego, United States
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