Abstract
Introduction:
This study explores the biomechanical impact of tibial extension stems in total knee arthroplasty using finite element digital modelling. The objective is to enhance stem selection by assessing stress and strain distribution in periprosthetic bone under varied loading scenarios.
Methods:
Six patient-specific FE models were created, each with different stem dimensions, to evaluate how stem geometry affects implant stability and fracture risk.
Results:
Extension stems reduce strain under the tibial baseplate but increase stress and fracture risk in the surrounding bone, particularly at the stem tip. Larger stem diameters were linked to higher fracture risks due to increased press-fit contact.
Conclusion:
These findings are consistent with previous research emphasizing the importance of stem design in achieving a balance between implant stability and bone preservation. The study offers a biomechanical foundation for surgical planning, potentially improving TKA durability and functional outcomes. Incorporating these insights into clinical practice may enhance the longevity of knee replacements and overall patient quality of life.
1 Introduction
Total knee arthroplasty (TKA), also known as total knee replacement, is an increasingly common surgical intervention that aims to definitively treat symptoms of osteoarthritis in our patients (; ). Although TKA survival rates are currently estimated at around 90% after 15 years (; ; ), there are still mechanical complications, particularly aseptic loosening, which can cause implant migration, which is the leading cause of early mechanical failure (; ). Additionally, it has been shown that obesity may increase the occurrence of these mechanical complications (). In the vast majority of cases, these much-feared complications result in a tricky surgical revision. These biomechanical complications seem to be mainly related to two factors: a pre-existing bone fragility and/or a suboptimal bone–implant interface in which loading is unevenly distributed across the epiphyseal surface ().
One potential solution to compensate for issues of bone fragility is the addition of tibial extension stems. These devices are believed to improve primary mechanical stability by increasing the intramedullary anchoring surface and/or establishing a more robust contact zone in the cortical bone. In this respect, previous studies have shown that extension stems significantly contribute to a reduction in equivalent stresses in osteoporotic epiphyses (; ). However, these extension systems have their limits, in particular the risk of bone resorption triggered by the phenomenon of stress shielding.
The use of a digital model based on finite element (FE) method might help surgeons during preoperative planning by including an analysis of what the mechanical response of periprosthetic bone might be depending on which stem is chosen (). The creation of these “digital twins” would provide a biomechanical basis for choosing a given stem and its length and diameter. Looking at the current literature, the choice at present seems to be at the surgeon’s discretion rather than having any real scientific basis.
Therefore, the objective of this study is to evaluate the biomechanical effect of tibial extension stems on the stability of the tibial component of the TKA, taking into account the mechanical properties of the recipient patient’s bone tissue. This research thus explores the creation of “patient-specific” models that make it possible to determine how stresses will be distributed across the periprosthetic bone and how stable implants will be based on the geometry of the extension stem.
2 Materials and methods
2.1 Development of the digital model
To develop the digital model, CT-scan images of the right knee of an 80-year-old male volunteer suffering from osteoarthritis were used (MR-004, IRB validated). The resulting volumes were composed of voxels of 0.449 × 0.449 × 0.499 mm3 in size. Next, the images were processed using semi-automatic volumetric image segmentation techniques using 3D Slicer software (Version 5.6.2, Kitware, France). The 3D geometry of the tibia was extracted and then imported into Ansys SpaceClaim (Version 2024R1, Ansys Inc., United States) to prepare the geometric model. To perform a virtual total arthroplasty, a 2 mm orthogonal cut was made to the tibial epiphysis under the damaged medial plateau at a joint line obliquity (JLO) of 3° (Figure 1a) to model a émechanical alignment of the tibial implant (). The dimensions of the cementless tibial insert’s endplate (U2 MB, United Orthopedic, Taiwan) were chosen to maximise coverage of the tibial section while ensuring that the implant did not protrude (Figure 1b). The implant positioning was validated by an experienced orthopaedic surgeon.
FIGURE 1
In this study, we considered press-fit tibial extension stems. Thus, once this implant in position, a boolean geometry operation was performed in the tibia to create a space for the implant (Figure 1c). Several models were developed in order to take into account multiple extension stem dimensions (may it be in diameter or in length). To develop the finite element models, each of the geometric models was then imported into the program Ansys Mechanical (Version 2024R1, Ansys Inc., United States). Discretisation of the different bodies was performed using quadratic tetrahedral elements (TET10).
To define optimal mesh parameters, in order to obtain a good accuracy of the results while maintaining reasonable computation costs, a convergence study was carried out (). In this study, the element type remained unchanged (TET10), and only the element size was varied. Several models were developed with element sizes ranging from 3 mm to 0.5 mm. An adaptive mesh refinement was applied in the contact region between the tibia and the implant components (tibial baseplate and extension stem), which was the main area of interest in this study. Mesh refinement was continued until the variation in results between two successive mesh densities was less than 5% for key output parameters, including strain, stress, and fracture risk. This ensured that the mesh was sufficiently refined to provide reliable and mesh-independent results in the regions under analysis.
As a result of the mesh convergence analysis, element size for the tibia and the implant was set to 1 mm, whereas in the contact zone around the bone and the prosthesis, element size was set to 0.75 mm (Figure 2a). With these parameters, each model was composed of approximately 2.6 million elements, and could be computed in about 1 hour.
FIGURE 2
Tibial baseplate and extension stem were assumed to be composed of cobalt–chrome–molybdenum (CoCrMo) (Table 1). For the tibia, the heterogeneous distribution of the patients’ bone density was taken into account (
TABLE 1
| Component | Material | Mechanical property | References |
|---|---|---|---|
| Tibia | Cortical bone | ν = 0.3 | |
| Cancellous bone | ν = 0.3 | ||
| Implant | CoCrMo | E = 220 GPa, ν = 0.3 |
Mechanical properties of materials used in the digital models.
The density limit for distinguishing between cortical and cancellous bone was set at 1.68 g/cm3 (
2.2 Structure of the study
In this study, one model was developed for a specific implant configuration, with longer or wider extension stems. A total of six models were developed. Model 1 corresponds to a tibia equipped with an implant used without an extension stem. Models 2 to 6 differ by the dimension of the stem. The dimensions of the extension stems correspond to those proposed in the U2 MB product range. This is summarised in Table 2.
TABLE 2
| Model 1 | Model 2 | Model 3 | Model 4 | Model 5 | Model 6 | |
|---|---|---|---|---|---|---|
| Stem Length (mm) | — | 20 | 45 | 70 | 45 | 45 |
| Stem Diameter (mm) | — | 9 | 9 | 9 | 12.5 | 14 |
Summary of the implant variations between each model.
The boundary conditions comprised the fixation of the distal part of the tibia and the application of a compressive force on the superior surface of the implant plateau, with the mechanical axis initially defined at the time of the proximal tibial cut (see Figure 2b). In order to more accurately model the distribution of the force on the physiological tibial plateau, 60% of the load was applied on the medial plateau, and 40% on the lateral plateau (
For each of the six models, strain and stress distribution were observed in the periprosthetic tibial bone, and the minimal principal strain were computed (
3 Results
Figure 3 illustrates the distribution of strains in the tibia under the tibial baseplate. The data indicates that models incorporating an extension stem exhibit less strain under the tibial baseplate across all three loading steps. For these models, the strain is primarily located in the bone surrounding the extremity of the stem. However, no difference in strain values was observed in the contact zone where the lateral fins of the implant engage with the tibia.
FIGURE 3

Distribution of strain over the tibial plateau, under the tibial baseplate.
A similar observation can be made from Figure 4, which shows the strain distribution in the periprosthetic bone. For each loading state, models with a stem exhibit very similar strain distribution. At the 12 BW loading step, Model 1 (without an extension stem) appears to have higher strain levels. However, the highest strain value was computed for Model 5.
FIGURE 4

Distribution of strains in the periprosthetic tibial bone.
Figure 5 shows the stress distribution in the periprosthetic tibial bone. We can observe that although the results are quite similar between all models, the models that implement an extension stem (models 2–6) tend to present higher stress values in the diaphysis cortical bone. The maximum stress values were determined in the Model 5.
FIGURE 5

Distribution of von Mises stresses (MPa) in the periprosthetic tibial bone.
Figure 6 shows the distribution of risk of fracture in the tibial bone (
FIGURE 6

Distribution of the risk of fracture (%) in the periprosthetic tibial bone (
Table 3 summarizes the results obtained for each simulation. It presents the maximum values of von Mises stress, equivalent elastic strain, and risk of fracture. For each of these mechanical fields, the lowest values were computed for Model 1. For Models 2 to 6 (which implement an extension stem), von Mises stress values are similar. Specifically, Model 6 (stem of 14 mm in diameter and 45 mm in length) shows values of 8.81 MPa at 3 BW, 14.68 MPa at 5 BW, and 35.24 MPa at 12 BW, compared to Model 2 (stem of 9 mm in diameter and 20 mm in length) with values of 9.52 MPa at 3 BW, 15.88 MPa at 5 BW, and 38.10 MPa at 12 BW. Similar observations can be made for equivalent elastic strain results, with peak strain values of 0.0012 at 3 BW, 0.0020 at 5 BW, and 0.0048 at 12 BW for these models.
TABLE 3
| Model 1 | Model 2 | Model 3 | Model 4 | Model 5 | Model 6 | ||
|---|---|---|---|---|---|---|---|
| 3 BW | Von Mises stress (max, MPa) | 8.30 | 9.52 | 9.37 | 8.94 | 9.33 | 8.81 |
| Equivalent elastic strain (max) | 0.0009 | 0.0010 | 0.0011 | 0.0010 | 0.0012 | 0.0010 | |
| Risk of fracture (max, %) | 3.29 | 4.31 | 4.41 | 4.28 | 4.81 | 4.25 | |
| Minimum principalmicro-strains (median (90th percentile)) | −121.56 (−214.67) | −140.59 (−383.67) | −146.01 (−396.69) | −149.37 (−395.17) | −141.74 (−376.05) | −142.55 (−379.75) | |
| 5 BW | Von Mises stress (max, MPa) | 13.84 | 15.88 | 15.62 | 14.90 | 15.55 | 14.68 |
| Equivalent elastic strain (max) | 0.0014 | 0.0017 | 0.0018 | 0.0017 | 0.0020 | 0.0017 | |
| Risk of fracture (max, %) | 5.48 | 7.19 | 7.35 | 7.14 | 8.01 | 7.08 | |
| Minimum principalmicro-strains (median (90th percentile)) | −202.60 (−357.78) | −234.32 (−639.45) | −243.36 (−661.15) | −248.96 (−658.62) | −236.23 (−626.76) | −237.58 (−632.92) | |
| 12 BW | Von Mises stress (max, MPa) | 33.21 | 38.10 | 37.48 | 35.76 | 37.32 | 35.24 |
| Equivalent elastic strain (max) | 0.0034 | 0.0041 | 0.0044 | 0.0042 | 0.0048 | 0.0041 | |
| Risk of fracture (max, %) | 13.14 | 17.26 | 17.64 | 17.13 | 19.23 | 16.99 | |
| Minimum principalmicro-strains (median (90th percentile)) | −486.25 (−858.68) | −562.36 (−1534.70) | −584.06 (−1586.80) | −597.50 (−1580.70) | −566.95 (−1504.20) | −570.20 (−1519.00) |
Summary of the results of von Mises stress, equivalent elastic strain, risk of fracture, and Minimum principal strain, for each of the 3 loading states.
Finally, we examined the median and 90th percentile values for minimal principal µ-strain, linked to a compressive load (
4 Discussion
In this study, various finite element (FE) models of knees with implants were developed to evaluate the biomechanical effects of adding an extension stem on the stability of total knee replacements. These patient-specific models account for the mechanical properties of the recipient’s bone. The results suggest that adding an extension stem tends to reduce strain under the tibial baseplate. However, stress appears to increase in the bone surrounding the extremity of the extension stem, regardless of stem dimensions.
To assess the plausibility of the strain levels predicted by our finite element models, we compared them with published experimental data (
The geometric parameter of the stem that appears to have the greatest impact on fracture risk is the diameter. Our results show that for each loading state, stems with the largest diameters (12.5 mm and 14 mm) exhibit the largest zones of high fracture risk and strain. A similar observation was previously noted in the literature by
Our findings align with observations by
In addition,
These findings should be interpreted as biomechanical tendencies under the bonded interface assumption, and they should not be directly translated into clinical recommendations for press-fit stem selection without additional validation, including explicit modelling of initial stability and micromotion.
In this study, we focused on secondary stability with secure anchorage of the prosthesis in the tibia. Future work could extend this approach to primary stability to assess the impact of anchorage on our results (
5 Conclusion
This study highlights the critical role of tibial extension stems in improving the biomechanical stability of total knee arthroplasty. Our results show that in the case of compressive loadings, the addition of an extension stem tends to increase both stress and strain in the periprosthetic bone, in particular around the extension stem, but seems to decrease their values under the implant’s baseplate. In addition, an increase in stem diameter correlates with a higher risk of fracture due to increased cortical contact within the tibia. Using patient-specific finite element models, this work provides the basis for a surgical planning strategy based on accurate biomechanical data. This approach allows surgeons to optimise implant selection, thereby improving durability and functional outcomes for patients. By integrating these findings into clinical practice, we can potentially improve the longevity of knee replacements and the overall quality of life for patients.
Statements
Data availability statement
The datasets presented in this article are not readily available because results obtained from patients imaging. Requests to access the datasets should be directed to MS, mathieu.severyns@hotmail.fr.
Ethics statement
The studies involving humans were approved by MR-004 reference methodology framework. The studies were conducted in accordance with the local legislation and institutional requirements. The participants provided their written informed consent to participate in this study.
Author contributions
MS: Validation, Methodology, Writing - original draft, Visualization, Conceptualization, Investigation. FZ: Conceptualization, Formal Analysis, Data curation, Methodology, Software, Writing – original draft. MG: Software, Data curation, Writing – original draft, Formal Analysis. AG: Writing – original draft, Methodology, Investigation, Data curation. TV: Writing – original draft, Investigation, Data curation, Project administration.
Funding
The author(s) declare that no financial support was received for the research and/or publication of this article.
Acknowledgments
We would like to thank United Orthopedic for providing the 3D models of the implants.
Conflict of interest
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Generative AI statement
The author(s) declare that no Generative AI was used in the creation of this manuscript.
Any alternative text (alt text) provided alongside figures in this article has been generated by Frontiers with the support of artificial intelligence and reasonable efforts have been made to ensure accuracy, including review by the authors wherever possible. If you identify any issues, please contact us.
Publisher’s note
All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article, or claim that may be made by its manufacturer, is not guaranteed or endorsed by the publisher.
References
1
AubertK.GermaneauA.RochetteM.YeW.SeverynsM.BillotM.et al (2021). Development of digital twins to optimize trauma surgery and postoperative management. A case study focusing on tibial plateau fracture. Front. Bioeng. Biotechnol.9 (octobre), 722275. 10.3389/fbioe.2021.722275
2
AwadallaM.Al-DiriniR. M. A.O’RourkeD.SolomonL. B.HeldrethM.TaylorM. (2018). Influence of varying stem and metaphyseal sleeve size on the primary stability of cementless revision tibial trays used to reconstruct AORI IIA defects. A simulation study. J. Orthop. Res.36 (7), 1876–1886. 10.1002/jor.23851
3
AyturkU. M.PuttlitzC. M. (2011). Parametric convergence sensitivity and validation of a finite element model of the human lumbar spine. Comput. Methods Biomechanics Biomed. Eng.14 (8), 695–705. 10.1080/10255842.2010.493517
4
BaeD. K.SongS. J.ParkM. J.Hyung EohJ.SongJ. H.ParkC. H. (2012). Twenty-year survival analysis in total knee arthroplasty by a single surgeon. J. Arthroplasty27 (7), 1297–1304.e1. 10.1016/j.arth.2011.10.027
5
CalliessT.BocklageR.KarkoschR.MarschollekM.WindhagenH.SchulzeM. (2014). Clinical evaluation of a mobile sensor-based gait analysis method for outcome measurement after knee arthroplasty. Sensors (Basel)14 (9), 15953–15964. 10.3390/s140915953
6
CattaneoP. M.DalstraM.FrichL. H. (2001). A three-dimensional finite element model from computed tomography data: a semi-automated method. Proc. Inst. Mech. Eng. H.215, 203–212. 10.1243/0954411011533760
7
CompletoA.TalaiaP.FonsecaF.SimõesJ. A. (2009). Relationship of design features of stemmed tibial knee prosthesis with stress shielding and end-of-stem pain. Mater. and Des.30 (4), 1391–1397. 10.1016/j.matdes.2008.06.071
8
ConliskN.HowieC. R.PankajP. (2018). Optimum stem length for mitigation of periprosthetic fracture risk following primary total knee arthroplasty: a finite element study. Knee Surg. Sports Traumatol. Arthrosc.26 (5), 1420–1428. 10.1007/s00167-016-4367-8
9
CorreaT. A.PalB.van ArkelR. J.VanacoreF.AmisA. A. (2018). Reduced tibial strain-shielding with extraosseous total knee arthroplasty revision system. Med. Eng. and Phys.62 (décembre), 22–28. 10.1016/j.medengphy.2018.09.006
10
CucklerJ. M. (2004). Bone loss in total knee arthroplasty. J. Arthroplasty19 (4), 56–58. 10.1016/j.arth.2004.03.002
11
DruelJ.GelinN.OllivierM.RoserenF.ChabrandP.JacquetC.et al (2024). Outcomes of short and long tibial stems for primary total knee arthroplasty in a population of obese patients at two-year follow-up: a clinical and biomechanical study. J. arthroplasty39 (8S1), S174–S182. 10.1016/j.arth.2024.02.047
12
EidelB.GoteA.FritzenC. P.OhrndorfA.ChristH. J. (2021). Tibial implant fixation in TKA worth a revision? how to avoid stress-shielding even for stiff metallic implants. Comput. methods biomechanics Biomed. Eng.24 (3), 320–332. 10.1080/10255842.2020.1830274
13
EseZ.WaldemarZ. (2019). Influence of 12-bit and 16-bit CT values of metals on dose calculation in radiotherapy using PRIMO, a Monte Carlo code for clinical linear accelerators. Curr. Dir. Biomed. Eng.5 (1), 597–600. 10.1515/cdbme-2019-0150
14
FrehillB.CrocombeA. D.AgarwalY.BradleyW. N. (2015). Finite element assessment of block-augmented total knee arthroplasty. Comput. methods biomechanics Biomed. Eng.18 (15), 1726–1736. 10.1080/10255842.2014.948429
15
HuizingaM. R.BrouwerR. W.BisschopR.Van Der VeenH. C.Akker-ScheekI. V. D.van RaayJ. J. (2012). Long-term follow-up of anatomic graduated component total knee arthroplasty. J. Arthroplasty27 (6), 1190–1195. 10.1016/j.arth.2011.11.020
16
KimY.-H.ParkJ.-W.JangY.-S. (2021). The 22 to 25-year survival of cemented and cementless total knee arthroplasty in young patients. J. Arthroplasty36 (2), 566–572. 10.1016/j.arth.2020.08.001
17
KurtzS.OngK.LauE.MowatF.HalpernM. (2007). Projections of primary and revision hip and knee arthroplasty in the United States from 2005 to 2030. J. Bone and Jt. Surg.89 (4), 780–785. 10.2106/JBJS.F.00222
18
LaverL.MamanD.HirschmannM. T.MahamidA.BarO.SteinfeldY.et al (2024). Big data analysis reveals significant increases in complications, costs, and hospital stay in revision total knee arthroplasty compared to primary TKA. Knee Surg. Sports Traumatol. Arthrosc.9, 1015–1024. 10.1002/ksa.12499
19
LeeH. H.HongH.-T.KimJ.-K.KohY.-G.KwanK. P.KangK.-T. (2025). Optimization of tibial stem geometry in total knee arthroplasty using design of experiments: a finite element analysis. Bioengineering12 (2), 172. 10.3390/bioengineering12020172
20
LuyckxT.BoriE.SaldariR.FioreS.AltamoreV.InnocentiB. (2024). Effect of design and surgical parameters variations in mobile‐bearing versus fixed‐bearing unicompartmental knee arthroplasty: a finite element analysis. J. Exp. Orthop.11 (4), e70053. 10.1002/jeo2.70053
21
MabryT. M.HanssenA. D. (2007). The role of stems and augments for bone loss in revision knee arthroplasty. J. Arthroplasty22 (4), 56–60. 10.1016/j.arth.2007.02.008
22
MündermannA.DyrbyC. O.D’LimaD. D.ColwellC. W.Jr.AndriacchiT. P. (2008). In vivo knee loading characteristics during activities of daily living as measured by an instrumented total knee replacement. J. Orthop. Res.26 (9), 1167–1172. 10.1002/jor.20655
23
PiovanG.BoriE.PadalinoM.PianigianiS.BernardoI. (2024). Biomechanical analysis of patient specific cone vs conventional stem in revision total knee arthroplasty. J. Orthop. Surg. Res.19 (1), 439. 10.1186/s13018-024-04936-0
24
PutmanS.ArgensonJ.-N.BonnevialleP.EhlingerM.VieP.LeclercqS.et al (2018). Ten-year survival and complications of total knee arthroplasty for osteoarthritis secondary to trauma or surgery: a French multicentre study of 263 patients. Orthop. and Traumatology Surg. and Res.104 (2), 161–164. 10.1016/j.otsr.2017.11.019
25
RhoJ. Y.HobathoM. C.AshmanR. B. (1995). Relations of mechanical properties to density and CT numbers in human bone. Med. Eng. and Phys.17 (5), 347–355. 10.1016/1350-4533(95)97314-F
26
RivièreC.IranpourF.AuvinetE.AframianA.AsareK.HarrisS.et al (2017). Mechanical alignment technique for TKA: are there intrinsic technical limitations?Orthop. and Traumatology Surg. and Res.103 (7), 1057–1067. 10.1016/j.otsr.2017.06.017
27
RooneyB. D.DerrickT. R. (2013). Joint contact loading in forefoot and rearfoot strike patterns during running. J. Biomechanics46 (13), 2201–2206. 10.1016/j.jbiomech.2013.06.022
28
SaxbyD. J.ModeneseL.BryantA. L.GerusP.KillenB.FortinK.et al (2016). Tibiofemoral contact forces during walking, running and sidestepping. Gait and Posture49 (septembre), 78–85. 10.1016/j.gaitpost.2016.06.014
29
SchileoE.TaddeiF.MalandrinoA.CristofoliniL.VicecontiM. (2007). Subject-specific finite element models can accurately predict strain levels in long bones. J. Biomechanics40 (13), 2982–2989. 10.1016/j.jbiomech.2007.02.010
30
ScottC. E. H.BiantL. C. (2012). The role of the design of tibial components and stems in knee replacement. J. Bone Jt. Surg. Br. Volume94-B (8), 1009–1015. 10.1302/0301-620X.94B8.28289
31
ShuL.YamamotoK.YaoJ.SaraswatP.LiuY.MitsuishiM.et al (2018). A subject-specific finite element musculoskeletal framework for mechanics analysis of a total knee replacement. J. biomechanics77 (août), 146–154. 10.1016/j.jbiomech.2018.07.008
32
SnyderS. M.SchneiderE. (1991). Estimation of mechanical properties of cortical bone by computed tomography. J. Orthop. Res.9 (3), 422–431. 10.1002/jor.1100090315
33
WearneL. S.RapagnaS.AwadallaM.KeeneG.TaylorM.PerilliE. (2024). Quantifying the immediate post-implantation strain field of cadaveric tibiae implanted with cementless tibial trays: a time-elapsed micro-CT and digital volume correlation analysis during stair descent. J. Mech. Behav. Biomed. Mater.151 (mars), 106347. 10.1016/j.jmbbm.2023.106347
34
ZannoniC.MantovaniR.MarcoV. (1999). Material properties assignment to finite element models of bone structures: a new method. Med. Eng. and Phys.20 (10), 735–740. 10.1016/S1350-4533(98)00081-2
Summary
Keywords
total knee arthroplasty, extension stem, biomechanics, finite element analysis, patient specific
Citation
Severyns M, Zot F, Gardegaront M, Germaneau A and Vendeuvre T (2025) Optimising tibial extension stem selection in total knee arthroplasty: the role of digital modelling. Front. Bioeng. Biotechnol. 13:1634172. doi: 10.3389/fbioe.2025.1634172
Received
23 May 2025
Accepted
16 September 2025
Published
10 October 2025
Volume
13 - 2025
Edited by
Björn Rath, Clinic Wels-Grieskirchen, Austria
Reviewed by
Xiaogang Wu, Taiyuan University of Technology, China
Ming Hong Chau, Princess Margaret Hospital, Hong Kong SAR, China
Updates

Check for updates
Copyright
© 2025 Severyns, Zot, Gardegaront, Germaneau and Vendeuvre.
This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
*Correspondence: François Zot, francois.zot@univ-poitiers.fr
Disclaimer
All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.