ORIGINAL RESEARCH article
Front. Bioeng. Biotechnol.
Sec. Biosafety and Biosecurity
Volume 13 - 2025 | doi: 10.3389/fbioe.2025.1637056
Analysis of Compliance Issues and Influencing Factors in the Management of BSL-2 Laboratories for Pathogenic Microorganisms in Lishui, China
Provisionally accepted
- 1Lishui Center for Disease Control and Prevention, Lishui, China
- 2School of Medical Technology and lnformation Engineering, Zhejiang Chinese Medical University, Hangzhou, China
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The management of biosafety laboratories for pathogenic microorganisms is directly related to public health and the effectiveness of biological experiments. However, persistent noncompliance issues in biosafety level 2 (BSL-2) laboratory management remain a challenge. This study aimed to assess the quality control of BSL-2 laboratories for pathogenic microorganisms in Lishui.Methods: By combining the Biosafety Online Supervision Systems and on-site inspections, this study assessed the quality control of 73 medical institutions and the 128 biosafety laboratories under their management in Lishui.The results discovered that the 73 medical institutions had low compliance rates in several fields: Responsibilities of the biosafety management (80.82%), development of system documentation (65.75%), risk assessment (84.56%), training of laboratory personnel (82.19%), and biosafety labeling (52.05%). Additionally, 128 laboratories had low pass rates for the access control management system (85.94%), hand/eye wash and shower stations (85.94%), and biosafety cabinet operations (89.06%).This study demonstrates that future efforts should focus on strengthening laboratory personnel training and implementing biosafety management responsibilities to ensure safe and regulation-compliant operations in laboratories handling pathogenic microorganisms.
Keywords: biosafety, Pathogenic microorganisms, Quality control, online supervision systems, laboratory management
Received: 04 Jun 2025; Accepted: 24 Jul 2025.
Copyright: © 2025 Cong, Li, Lou, Zhu, Zhang, Cheng and Chen. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Deyong Zhang, Lishui Center for Disease Control and Prevention, Lishui, China
Dongqing Cheng, School of Medical Technology and lnformation Engineering, Zhejiang Chinese Medical University, Hangzhou, China
Xiuying Chen, Lishui Center for Disease Control and Prevention, Lishui, China
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