REVIEW article
Front. Bioeng. Biotechnol.
Sec. Organoids and Organ-On-A-Chip
Volume 13 - 2025 | doi: 10.3389/fbioe.2025.1637456
This article is part of the Research TopicInnovative Biomaterials for Organ-on-a-Chip and Microfluidic Healthcare ApplicationsView all articles
Organoid scaffold materials：research and application
Provisionally accepted
- 1Medical College, Guangxi University, Nanning, China
- 2Medical College of Guangxi University,No.100, Daxue East Road, Nanning, Guangxi, P.R. China ; The Fifth Hospital of Xiamen,No.101 Min 'an Road, Xiang 'an District, Xiamen, Fujian, P.R.China, Guangxi University, Nanning, China
- 3Xiamen Mogengel Biotechnology Co., Ltd, Guangxi University, Nanning, China
- 4Fujian Provincial Sperm Bank. Fujian Maternity and Child Health Hospital，18 Daoshan Road, Fuzhou City, Fujian Province. P R. China, Guangxi University, Nanning, China
- 5Medical College of Guangxi University,No.100, Daxue East Road, Nanning, Guangxi, P.R. China ;State Key Laboratory of Physical Chemistry of Solid Surfaces, Collaborative Innovation Center of Chemistry for Energy Materials, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen 361005, P. R. China, Guangxi University, Nanning, China
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In recent years, organoid research has witnessed remarkable progress, yet significant challenges remain in organoid construction. As fundamental architectural frameworks, organoid scaffolds play a pivotal role in facilitating three-dimensional tissue morphogenesis by delivering crucial biochemical and mechanical signals during in vitro organoid development. A systematic examination of scaffold functions in organoid culture systems, coupled with a critical assessment of different scaffold modalities, not only deepens our understanding of organoid biology and their microenvironment but also provides valuable insights for next-generation scaffold design. This review elucidates the fabrication principles and applications of organoid scaffolds, delineates their functional significance in organoid culture, categorizes existing scaffold systems with comparative analysis of their respective merits and limitations, and concludes with perspectives on future research directions in scaffold development.
Keywords: organoid scaffolds, Classification, Characteristics, culture, materials
Received: 29 May 2025; Accepted: 30 Jun 2025.
Copyright: © 2025 Zhang, Zhu, Luo, Q and Zeng. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Zq Q, Fujian Provincial Sperm Bank. Fujian Maternity and Child Health Hospital，18 Daoshan Road, Fuzhou City, Fujian Province. P R. China, Guangxi University, Nanning, China
Fanwei Zeng, Medical College of Guangxi University,No.100, Daxue East Road, Nanning, Guangxi, P.R. China ;State Key Laboratory of Physical Chemistry of Solid Surfaces, Collaborative Innovation Center of Chemistry for Energy Materials, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen 361005, P. R. China, Guangxi University, Nanning, China
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