REVIEW article
Front. Bioeng. Biotechnol.
Sec. Nanobiotechnology
Volume 13 - 2025 | doi: 10.3389/fbioe.2025.1637589
Green-Synthesized Metal Nanoparticles: A Promising Approach for Accelerated Wound Healing
Provisionally accepted
- University of Johannesburg, Johannesburg, South Africa
Select one of your emails
You have multiple emails registered with Frontiers:
Notify me on publication
Please enter your email address:
If you already have an account, please login
You don't have a Frontiers account ? You can register here
The green synthesis of metal nanoparticles (G-MNPs) in wound healing has shown a promising approach in recent decades. While chemical and physical methods have traditionally been employed for G-MNP synthesis, green synthesis methods are increasingly preferred due to their eco-friendly, safe, cost-effective, and efficient nature. These processes offer high productivity and purity without the need for high pressure, temperature, or toxic and hazardous substances, and they eliminate the need for external reducing, stabilizing, or capping agents.The green synthesis of G-MNPs can occur intra-or extracellularly and can be facilitated by various biological entities, including bacteria, fungi, yeast, algae, actinomycetes, and plant extracts. The rapid advancements in nanotechnology have been significantly propelled by the development of engineered, green-synthesized metal nanoparticles (G-MNPs). These nanoparticles have been extensively investigated for their potential applications in various biomedical fields. Their inert nature and nanoscale dimensions, which are comparable to many biological molecules, make them highly attractive in the biomedical field. Moreover, their intrinsic properties, including electronic, optical, physicochemical characteristics, and surface plasmon resonance, are highly tunable by altering parameters such as particle size, shape, environment, aspect ratio, synthesis methods, and functionalization. This tunability has facilitated their broad application in biomedicine, encompassing areas such as targeted drug delivery, biosensing, photothermal and photodynamic therapies, imaging, and the integration of multiple therapeutic modalities. This review article explores the various properties of metallic nanoparticles and their applications in the biomedical sciences while also addressing the challenges associated with their clinical translation.
Keywords: Metal Nanoparticles, Drug delivery, Wound Healing, biosensing, biomedicine, Green synthesis
Received: 29 May 2025; Accepted: 01 Jul 2025.
Copyright: © 2025 Singaravelu, Motsoene, Abrahamse and Dhilip Kumar. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Sathish Sundar Dhilip Kumar, University of Johannesburg, Johannesburg, South Africa
Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.