REVIEW article
Front. Bioeng. Biotechnol.
Sec. Nanobiotechnology
Volume 13 - 2025 | doi: 10.3389/fbioe.2025.1638668
This article is part of the Research TopicThe Role of Nanostructured Materials in Targeted Drug DeliveryView all 4 articles
Nano-structured Strategies in Combatting Neurodegeneration
Provisionally accepted
- 1NITTE, Mangaluru, India
- 2Nehru Arts and Science College, Coimbatore, India
- 3Queen Elizabeth Hospital, Kowloon, Hong Kong SAR, China, Kowloon,, Hong Kong, SAR China
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Word count: 249 Parkinson's disease (PD) is a progressive neurodegenerative disorder that is characterized by the loss of dopaminergic neurons, leading to severe motor and cognitive impairments. Recent advancements in nanomedicine and nano-structured technologies have opened new avenues for targeted drug delivery and neuroprotection, improving therapeutic efficacy and diagnostic precision. By harnessing innovative nanotechnological platforms, researchers aim to enhance clinical trial outcomes and refine early-stage diagnostic advancements, offering hope for improved disease management. However, since the pathophysiology of PD is very extensive and diverse, there are very limited treatment options available currently, in spite of the developments in modern medicines. This limitation in treatment options underscores the compelling demand for innovative therapeutic interventions. This review explores the transformative potential of the recent nanostructured technologies in managing the complexities of PD. Deliberations on the insights from nanomedicine, neurobiology, and material science, on how these emerging and technologically sound nanostructured approaches help in the prevention, treatment, and diagnosis of PD will be discussed in due course. Further, the role of nanocarriers in targeted drug delivery involving nanoscale materials specifically for neuroprotection and regeneration will be discussed with special emphasis on the role of nanotechnology in advancing diagnostic methodologies. Additionally, this review aims to chart a course for future research directions, with special reference to innovative approaches in disease diagnosis. Discussions on the various therapeutic approaches along with the ongoing clinical trials and real-world applications are expected to add value to the efforts of the researchers worldwide to enhance therapeutic efficacy and patient outcomes in Parkinson's Disease.
Keywords: Parkinson's disease, Dopaminergic Neurons, Nano-structured Technologies, Nanomedicine, Targeted Drug Delivery, Neuroprotection, neurodegeneration
Received: 31 May 2025; Accepted: 24 Sep 2025.
Copyright: © 2025 Prasanth, Mallya, Cho and Mundekkad. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Deepa Mundekkad, deepamundekkad@gmail.com
Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.