REVIEW article
Front. Bioeng. Biotechnol.
Sec. Biomaterials
Volume 13 - 2025 | doi: 10.3389/fbioe.2025.1639034
This article is part of the Research TopicBiodegradable Polymers for Biomedical Applications - Volume IVView all 4 articles
Advances in Hyaluronic Acid Hydrogel for Meniscus Repair
Provisionally accepted
- 1The Fourth People's Hospital of Shenyang, Shenyang, China
- 2Qianjiang people’s hospital, Qianjiang, China
- 3Shenyang Sport University, Shenyang, China
Select one of your emails
You have multiple emails registered with Frontiers:
Notify me on publication
Please enter your email address:
If you already have an account, please login
You don't have a Frontiers account ? You can register here
The meniscus, an important fibrocartilaginous structure within the knee joint, plays essential roles in shock absorption, joint stabilization, and the optimization of mechanical force transmission. Meniscus injuries are common among athletes, middle-aged and elderly individuals, and those engaged in heavy physical labor. Both conservative and surgical treatments currently have limitations, making it difficult to achieve complete repair and functional restoration of meniscal tissue. In recent years, hyaluronic acid (HA) hydrogel has shown broad potential in meniscus repair due to its excellent biocompatibility and biodegradability. As a cell carrier, this material not only promotes cell migration, proliferation, and differentiation but also mimics the biomechanical properties of the meniscus, regulates the inflammatory environment, and facilitates angiogenesis, thereby creating favorable conditions for tissue regeneration. This review summarizes the mechanisms, current applications, and research advances of HA hydrogel in meniscus repair, aiming to provide new theoretical foundations and technical support for meniscus injury treatment and to promote clinical translation and development in this field.
Keywords: Meniscus injury, Hyaluronic acid hydrogel, Meniscus repair, Cell carrier, Tissue Engineering, Regenerative Medicine
Received: 01 Jun 2025; Accepted: 02 Jul 2025.
Copyright: © 2025 Wang, Liu, Zhang and Hu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Xin-an Zhang, Shenyang Sport University, Shenyang, China
Mingjie Hu, Shenyang Sport University, Shenyang, China
Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.