REVIEW article
Front. Bioeng. Biotechnol.
Sec. Tissue Engineering and Regenerative Medicine
Volume 13 - 2025 | doi: 10.3389/fbioe.2025.1639060
This article is part of the Research TopicTranslation of Mesenchymal Stem Cells in vivo: Evidence from preclinical and clinical testing.View all 8 articles
Hyperbaric oxygen combined with exosomes: a new strategy to promote tissue repair
Provisionally accepted
- Department of Rehabilitation Medicine, First Affiliated Hospital, Dalian Medical University, Dalian, China
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Tissue repair is an essential mechanism for restoring damage caused by disease and maintaining life in organisms. Hyperbaric oxygen therapy, as a non-invasive physical treatment, has been utilized to address various tissue damage conditions. Exosomes are nanoscale vesicles released into the extracellular environment by animal cells. Their structure comprises a phospholipid bilayer membrane and includes specific functional active components, such as nucleic acids, lipids, and proteins. It can precisely modulate the behavior of target cells, restore the balance of the microenvironment, and stimulate endogenous regeneration and repair mechanisms, representing a novel tool in regenerative medicine. Evidence indicates that hyperbaric oxygen in conjunction with exosomes can markedly enhance tissue healing. Currently, there is a paucity of research about the synergistic application of the two, however they are intrinsically linked to the principles of tissue repair. Therefore, this article systematically explains the application and mechanism of hyperbaric oxygen and exosomes therapy on tissue repair, the interaction between the two, and the combined application of the two, and analyzes the safety and transformation obstacles of the combined treatment strategy, in order to provide new ideas for future combined research and clinical application.
Keywords: Hyperbaric oxygen1, exosomes2, small extracellular vesicles3, Tissue Repair4, regenerative medicine5
Received: 01 Jun 2025; Accepted: 28 Aug 2025.
Copyright: © 2025 Zhang, Zhou, Liu, Li, Liu and Gao. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Yong Liu, Department of Rehabilitation Medicine, First Affiliated Hospital, Dalian Medical University, Dalian, China
Yuling Gao, Department of Rehabilitation Medicine, First Affiliated Hospital, Dalian Medical University, Dalian, China
Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.